58699-61-9 Usage
Uses
Used in Chemical Biology and Biochemistry Research:
2'-Azido-d-adenosine is used as a research tool for studying nucleic acid structure and function due to its reactive azido group, which facilitates the investigation of adenosine and related molecules in various biological contexts.
Used in Labeling and Tagging Experiments:
In the field of molecular biology, 2'-Azido-d-adenosine is used as a labeling agent to track and study the behavior of adenosine and related molecules, providing insights into their roles in cellular processes.
Used in Antiviral Drug Development:
2'-Azido-d-adenosine is explored as a potential antiviral agent, leveraging its unique properties to inhibit viral replication and offering a new avenue for the development of antiviral therapies.
Used in Cancer Treatment Research:
2'-Azido-d-adenosine is also being investigated for its potential in cancer treatment, with studies focusing on its ability to target cancer cells and contribute to the development of novel therapeutic strategies against various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 58699-61-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,6,9 and 9 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 58699-61:
(7*5)+(6*8)+(5*6)+(4*9)+(3*9)+(2*6)+(1*1)=189
189 % 10 = 9
So 58699-61-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H13N8O3/c11-8-6-9(14-2-13-8)18(3-15-6)10-5(16-17-12)7(20)4(1-19)21-10/h2-5,7,10,12,19-20H,1H2,(H2,11,13,14)/q+1
58699-61-9Relevant articles and documents
Synthesis of non-hydrolyzable substrate analogs for Asp-tRNAAsn/Glu-tRNAGln amidotransferase
Klinchan, Chayada,Hsu, Yu-Ling,Lo, Lee-Chiang,Pluempanupat, Wanchai,Chuawong, Pitak
, p. 6204 - 6207 (2014/12/10)
Non-hydrolyzable substrate analogs for tRNA-dependent amidotransferase, 2′- or 3′-aspartyl or -glutamyl adenosine, were synthesized from adenosine without protection of the adenine base. The hydroxyl groups of adenosine were selectively protected, followed by a series of oxidation/reductions to alter the stereochemistry. DFT calculations revealed the driving forces for the ketone hydrate formation at C-2′, but not the C-3′ carbon during the oxidation step. Subsequently, triflation and azide replacement yielded azidoadenosines, which were coupled to protected amino acids after deprotection and reduction. After global deprotection, the target substrate analogs were obtained in 2-14% overall yields from adenosine.
SYNTHESIS AND PROPERTIES OF OLYGOADENYLIC ACIDS CONTAINING 2'-5' PHOSPHORAMIDE LINKAGE
Sawai, Hiroaki
, p. 805 - 808 (2007/10/02)
Olygoadenylic acids containing 2'-5' phosphoramide linkage were prepared by poly (U) template-directed condensation.Some of their properties are described.
