592478-37-0

Basic information

• Product Name: 3-METHYL-2-AZA-SPIRO[4.5]DECANE
• Synonyms: 3-METHYL-2-AZA-SPIRO[4.5]DECANE
• CAS NO: 592478-37-0
• Molecular Formula: C10H19N
• Molecular Weight: 153.26456
• Mol File: 592478-37-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-METHYL-2-AZA-SPIRO[4.5]DECANE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-2-AZA-SPIRO[4.5]DECANE(592478-37-0)
• EPA Substance Registry System: 3-METHYL-2-AZA-SPIRO[4.5]DECANE(592478-37-0)

Safety Data

• Hazardous Substances Data: 592478-37-0(Hazardous Substances Data)

Upstream product

• 81097-43-0 1-allyl-1-(aminomethyl)cyclohexane 
• 676132-37-9 1-allylcyclohexane-1-nitrile 
• 766-05-2 cyclohexane carbonitrile 

Downstream Products

• 1360864-33-0 2-(4-chlorophenethyl)-3-methyl-2-azaspiro[4,5]decane 

Relevant articles and documents

Enantioselective intramolecular hydroamination catalyzed by lanthanide ate complexes coordinated by N-substituted (R)-1,1′-binaphthyl-2,2′- diamido ligands

Ytterbium and lutetium ionic complexes derived from enantiopure substituted (R)-binaphthylamine ligands, of the general formula [Li(THF) n][Ln[(R)-C20H12(NR)2]2], have been investigated for the hydroa

Neutral yttrium tris(amide) and ate complexes coordinated by an (R)-N,N′-diisopropyl-1,1′-binaphthyl-2,2′-diamido ligand as enantioselective catalysts for intramolecular hydroamination

A bis(amido)yttrium chloride coordinated by (R)-N,N′-diisopropyl-1, 1′-binaphthyl-2,2′-diamide [Y{(R)-C20H 12(NiPr)2}-Cl(thf)2] has been prepared and characterized by X-ray analysis along with the corresponding

LiCl-effect on asymmetric intramolecular hydroamination catalyzed by binaphthylamido yttrium complexes

Chiral alkyl or amido yttrium complexes were prepared from N-silyl- or N-cyclopentyl-substituted binaphthylamido ligands. According to the synthetic procedure, these complexes could be obtained in their neutral form or as heterobimetallic complexes in the

Synthesis of enantiomeric pure zirconium and hafnium benzamidinate complexes

Two enantiomerically pure group 4 amidinate complexes [{(S)-PEBA} 2Zr(NMe2)2] and [{(S)-PEBA} 2Hf(NMe2)2] containing the chiral amidinate N,N′-bis-((S)-1-phenylethyl)benzamidinate ((S)-PEBA

Calcium catalyzed enantioselective intramolecular alkene hydroamination with chiralC2-symmetric bis-amide ligands

The chiral building block (R)-(+)-2,2′-diamino-1,1′-binaphthyl, (R)-BINAM, which is often used as backbone in privileged enantioselective catalysts, was converted to a series ofN-substituted proligandsR1-H2(R = CH2tBu, C(H

Lanthanide complexes coordinated by N-substituted (R)-1,1′- binaphthyl-2,2′-diamido ligands in the catalysis of enantioselective intramolecular hydroamination

A new family of lanthanide ionic complexes derived from chiral, substituted (R)-binaphthylamine ligands, [Li(thf)4][Ln{(R)-C20H 12(NR)2}2] (Ln = Yb, Sm, Nd, or Lu), has been synthesized and characterized by X-ray crystal structure analyses. All complexes have been tested as new catalysts for the hydroamination/cyclization of 1-(aminomethyl)-1-allylcyclohexane. Ytterbium complexes proved to be both the most active and the most enantioselective, and the use of the complex [Li(thf)4][Yb{(R)-C20H12(NC3H 7)2}2], bearing isopropyl radicals on the nitrogen atoms, allowed the formation of the corresponding spiropyrrolidine in high yield with up to 70% ee.

Simple chiral diaminobinaphthyl dilithium salts for intramolecular catalytic asymmetric hydroamination of amino-1,3-dienes

Simple and easily accessible chiral lithium amide salts are reported as efficient (pre)catalysts for the diastereo- [up to (E:Z) = 92:8] and enantioselective [up to 72% ee (E)] hydroamination/cyclisation of conjugated primary aminodienes. These chiral lithium salts are straightforwardly prepared by in situ combination of an N-substituted (R)-(+)l,l'-binaphthyl-2,2'-diamine ligand and a commercial methyllithium solution. Information on the solid-state structure of these salts was obtained by X-ray analysis of a single crystal.

Intramolecular Alkene Hydroamination with Hybrid Catalysts Consisting of a Metal Salt and a Neutral Organic Base

Hybrid catalysts consisting of alkaline earth iodides (AeI2) and the Schwesinger base tBuP4 catalyse the intramolecular alkene hydroamination of H2C=CHCH2CR2CH2NH2 [CR2/sub

On the Superior Activity of In(I) versus In(III) Cations Toward ortho-C-Alkylation of Anilines and Intramolecular Hydroamination of Alkenes

An efficient ortho-C-alkylation of unprotected anilines with a variety of styrenes and alkenes using a univalent cationic indium(I) catalyst is reported. Mechanistic studies revealed that the reaction likely proceeds via a tandem hydroamination/Hofmann-Martius rearrangement. The high compatibility between the cationic indium(I) complex and primary anilines led us to develop an In(I)+-catalyzed hydroamination of alkenes using unprotected primary and secondary alkenylamines. Computations support the catalytic activity of naked In(I)+ ions, with an outer sphere mechanism for the C-N bond formation and a potentially inner sphere protodemetallation.

Bulky guanidinate calcium and zinc complexes as catalysts for the intramolecular hydroamination

Mixed guanidinato-amido supported complexes of calcium, LCaN(SiMe3)2?2THF (1) [L = {ArNC(NiPr2)NAr} (Ar = 2,6-Me2-C6H3)] and zinc, LZnN(SiMe3)2 (2) & L