- Study on the Structure of Cu/ZrO2 Catalyst and the Formation Mechanism of Disodium Iminodiacetate and Sodium Glycine
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Abstract: A new method to prepare Cu/ZrO2 catalysts by reducing CuO/ZrO2 with hydrazine hydrate is reported, and the prepared catalysts were used to synthesize disodium iminodiacetate by diethanolamine dehydrogenation. Hydrazine hydrate can rapidly reduce the CuO/ZrO2 precursor powder in an alkaline environment at a moderate temperature. The ratio of Cu0/Cu+ at the Cu/ZrO2 surface was controlled by the amount of hydrazine hydrate and the reduction reaction time. The formation mechanism of disodium glycine as the main byproduct and iminodiacetate were deduced by investigating the product yield, the reaction time, and the presence of acetaldehyde in the evolved gas. It has been shown that the ratio of Cu0/Cu+ in Cu/ZrO2 significantly affects the dehydrogenation of diethanolamine into disodium iminodiacetate. Cu0 and Cu+ are the catalytic activity centers in the dehydrogenation of diethanolamine which respectively produce intermediate aldehydes and an ester via nucleophilic addition reactions. The formation mechanism of sodium glycinate is related to the tautomerism of intermediate products and Schiff base hydrolysis. Graphic Abstract: The formation mechanism of disodium iminodiacetate and sodium glycine producing by the dehydrogenation of diethanolamine over the Cu/ZrO2 catalysts which were prepared by a new reduction method.
- Wang, Yongsheng,Zhu, Hongwen,Duan, Zhengkang,Zhao, Zhenzhen,Zhao, Yunlu,Lan, Xiaolin,Chen, Li,Guo, Dongjie
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Read Online
- A bio-based benzoxazine surfactant from amino acids
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A novel bio-based benzoxazine (Ca-g) surfactant was synthesizedviaa Mannich reaction using renewable glycine and cardanol as raw materials. The structure of Ca-g was characterized by NMR, FT-IR, and elemental analysis. Styrene containing emulsions and polystyrene (PS) latex were prepared based on the Ca-g surfactant. These results showed that the Ca-g surfactant exhibited high efficiency for stabilizing styrene emulsions. An addition of only 1.7 (w/v)% stabilized the high internal phase emulsion (HIPE) with a styrene volume fraction up to 90%. More interestingly, HIPE exhibited pH-sensitivity and could be formed at pH values from 9.0 to 12.0. Furthermore, PS particles were obtainedviaHIPE polymerization. In addition, thein vitrocytotoxicity of Ca-g and its triglyceride emulsion was also investigated. Ca-g showed lower cytotoxicity against the HeLa cell line. A stable triglyceride-in-water emulsion stabilized by Ca-g was prepared. The bio-based Ca-g surfactant may have potential use in cosmetics and daily cleaning products.
- Gao, Sheng,Gong, Xinjian,Lu, Zaijun,Song, Kun,Wang, Zheng,Yao, Shu,Zhang, Sujuan
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Read Online
- Synthesis, characterization, DNA and HSA binding studies of isomeric Pd (II) antitumor complexes using spectrophotometry techniques
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Two new Palladium(II) isomeric complexes, [Pd (Gly)(Leu)](I) and [Pd (Gly)(Ile)](II), where Gly is glycine, and Leu and Ile are isomeric amino acids (leucine and isoleucine), have been synthesized and characterized by elemental analysis, molar conductivity measurements, FT-IR, 1H NMR, and UV–Vis. The complexes have been tested for their In vitro cytotoxicity against cancer cell line K562 and their binding properties to calf thymus DNA (CT-DNA) and human serum albumin (HSA) have also been investigated by multispectroscopic techniques. Interactions of these complexes with CT-DNA were monitored using gel electrophoresis. The energy transfer from HSA to these complexes and the binding distance between HSA and the complexes (r) were calculated. The results obtained from these studies indicated that at very low concentrations, both complexes effectively interact with CT-DNA and HSA. Fluorescence studies revealed that the complexes strongly quench DNA bound ethidium bromide as well as the intrinsic fluorescence of HSA through the static quenching procedures. Binding constant (Kb), apparent biomolecular quenching constant (kq), and number of binding sites (n) for CT-DNA and HSA were calculated using Stern–Volmer equation. The calculated thermodynamic parameters indicated that the hydrogen binding and vander Waals forces might play a major role in the interaction of these complexes with HSA and DNA. Thus, we propose that the complexes exhibit the groove binding with CT-DNA and interact with the main binding pocket of HSA. The complexes follow the binding affinity order of I?>?II with DNA- and II?>?I with HSA-binding.
- Zareian-Jahromi, Sareh,Mansouri-Torshizi, Hassan
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p. 1329 - 1350
(2017/09/30)
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- MANUFACTURING METHOD OF AMINOCARBOXYLIC ACID SALT
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PROBLEM TO BE SOLVED: To provide a manufacturing method of aminocarboxylic acid salt capable of suppressing and inhibiting generation of fastening of a coloring component in a reaction liquid containing the aminocarboxylic acid salt manufactured by oxidation dehydrogenation of amino alcohol in the presence of a copper-containing catalyst or capable of suppressing and inhibiting production of precipitate during manufacturing the aminocarboxylic acid from aminocarboxylic acid salt. SOLUTION: There is provided a manufacturing method for aminocarboxylic acid salt including oxidation dehydrogenation of amino alcohol in the presence of a copper-containing catalyst to obtain a reaction product and removing the copper-containing catalyst from the reaction product to obtain a reaction liquid containing aminocarboxylic acid salt having limitation of the total content (in terms of metals) of silicon (Si), aluminum (Al) and iron (Fe) to 100 mass.ppm or less. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
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Paragraph 0076
(2017/06/15)
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- RUTHENIUM COMPLEXES AND THEIR USES AS CATALYSTS IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND RELATED REACTIONS
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The present invention relates to novel Ruthenium complexes of formulae A1-A4 and their use, inter alia, for (1) dehydrogenative coupling of alcohols to esters; (2) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (3) preparing amides from alcohols and amines—(including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or polymerization of amino alcohols and/or forming cyclic dipeptides from p-aminoalcohols; (4) hydrogenation of amides (including cyclic dipeptides, polypeptides and polyamides) to alcohols and amines; (5) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (6) dehydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water and a base to form carboxylic acids; and (10) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. The present, invention further relates to the use of certain known Ruthenium complexes for the preparation of amino acids or their salts from amino alcohols.
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Paragraph 0291; 0326
(2017/10/18)
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- General Synthesis of Amino Acid Salts from Amino Alcohols and Basic Water Liberating H2
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An atom-economical and environmentally friendly method to transform amino alcohols to amino acid salts using just basic water, without the need of pre-protection or added oxidant, catalyzed by a ruthenium pincer complex, is developed. Water is the solvent, the source of the oxygen atom of the carboxylic acid group, and the actual oxidant, with liberation of dihydrogen. Many important and useful natural and unnatural amino acid salts can be produced in excellent yields by applying this new method.
- Hu, Peng,Ben-David, Yehoshoa,Milstein, David
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supporting information
p. 6143 - 6146
(2016/06/09)
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- AMINO ACID SALT CONTAINING COMPOSITIONS
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A reagent composition for forming fatty acyl amido surfactants is provided which includes an alkali metal or alkaline earth metal salt of an amino compound; a polyol of molecular weight ranging from 76 to 300; and no more than 10% water.
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Page/Page column 13-14
(2013/03/26)
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- Equimolar CO2 capture by N-substituted amino acid salts and subsequent conversion
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Steric bulk controls CO2 absorption: N-substituted amino acid salts in poly(ethylene glycol) reversibly absorb CO2 in nearly 1:1 stoichiometry. Carbamic acid is thought to be the absorbed form of CO 2; this was supported by NMR and in situ IR spectroscopy, and DFT calculations. The captured CO2 could be converted directly into oxazolidinones and thus CO2 desorption could be sidestepped. Copyright
- Liu, An-Hua,Ma, Ran,Song, Chan,Yang, Zhen-Zhen,Yu, Ao,Cai, Yu,He, Liang-Nian,Zhao, Ya-Nan,Yu, Bing,Song, Qing-Wen
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supporting information
p. 11306 - 11310
(2013/01/15)
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- Hydration of amino acids from ultrasonic measurements
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In this paper the results of compressibility of aqueous solutions of amino acids in water and in aqueous HCl and NaOH solutions at 25 °C are presented. The effect of the charged protonated amino groups and deprotonated carboxylic groups on the hydration number was tested. The idea of additivity of the hydration number with the constituents of the solute molecule was successfully applied and discussed.
- Burakowski, Andrzej,Gliński, Jacek
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experimental part
p. 12157 - 12161
(2011/01/11)
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- Process for Preparing Creatine, Creatine Monohydrate or Guanidinoacetic Acid
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A process for producing creatine, creatine monohydrate or guanidinoacetic acid is proposed, wherein firstly N-methylethanolamine or ethanolamine is catalytically dehydrogenated in each case in alkaline solution and the sarcosinate or glycinate solutions that are obtained in this manner are finally reacted under acidic conditions with a guanylating agent such as for example O-alkylisourea or cyanamide. In this manner products are obtained in high yields and very good purity where in contrast to the prior art no traces whatsoever of hydrocyanic acid, formaldehyde, chloroacetic acid or ammonia are present. The formation of the toxicologically critical dihydrotriazine is also avoided.
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Page/Page column 2-3
(2009/07/10)
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- Process for preparation of Mannich condensation products useful as sequestering agents
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The present invention is directed to a process for preparing Mannich condensation product sequestering agents or mixtures of Mannich condensation product sequestering agents for use in fuels and lubricating oils.
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Page/Page column 24-25; 27
(2010/11/30)
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- METHOD FOR PRODUCING CARBOXYLIC ACID AND/OR ITS SALT
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PROBLEM TO BE SOLVED: To provide an industrially practicable method for producing a carboxylic acid and/or its salt by oxidizing the corresponding alcohol with molecular oxygen using a highly durable catalyst. SOLUTION: The method for producing the carboxylic acid and/or its salt comprises oxidizing the corresponding alcohol with molecular oxygen. Specifically, this method comprises carrying out the oxidation in an aqueous medium in the presence of a catalyst with gold-containing particles carried on a carrier containing titanium and/or zirconium. This method is excellent in high performance and catalyst durability.
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Page/Page column 9
(2008/06/13)
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- Method for binding albumin and means to be used in the method
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A method for binding albumin by contacting an aqueous liquid containing an albumin with an albumin-binding compound is selected from albumin-binding compounds containing the scaffold --CO--NH--C(=C--)--CO--, and conjugates that are capable of binding albumin and exhibiting the scaffold --CO--NH--C(=C--)--CO--.
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- Process to prepare amino carboxylic acid salts
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An improved process is discloses to prepare an amino carboxylic acid salt. According to the process an aqueous solution of an amino alcohol is contacted with an alkali metal hydroxide in the presence of an effective amount of Raney copper catalyst that has from about 10 parts per million of an element selected from the group consisting of bismuth, tin, antimony, lead, germanium and mixtures thereof.
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- Cephem compounds and anti-bacterial agent
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Disclosed is a novel cephem compound which is either one of a cis- or trans-isomer or a mixture of the cis-and trans-isomers, represented by the following general formula (I) and a pharmacologically acceptable salt thereof: STR1 wherein all of the substituents are as defined hereinbefore. Also disclosed are a process for producing the above compound and its use as an anti-bacterial agent comprising the same.
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- Preparation of herbicides containing a phosphonate group from intermediate benzoxazines
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Preparation of intermediates for herbicides of formula STR1 by the reaction of organic phosphites with benzoxazines of formula in which Bzx denotes the radical of formula: STR2 X is a usual substituent of phenols n is an integer from 0 to 4 R1 and R2 are H or such that OR1 and OR2 are hydrolyzable Y is --OM or --NR3 R4 M is H or is such that COOM is a salt or an ester R3 and R4 are H or a hydrocarbon radical, and one of them can be R5 --SO2 --, and R5 is a hydrocarbon radical, substiuted if appropriate. Products obtained by the process and their use as herbicides.
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- Mercaptoacylamidobenzoylglycine mucolytic process and compositions
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N-[3-(mercaptoacetylamino)benzoyl]glycine, alkali metal and amine salts thereof are potent topically effective mucolytic agents.
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- Methods of making basic zirconium complexes
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Basic zirconium gels may be used to form complexes with conventional aluminum and/or zirconium antiperspirant systems. The freshly prepared basic zirconium gels provide both a buffer for the highly acidic aluminum-zirconium complexes and an additional source of zirconium as an active ingredient in the antiperspirant. The preferred basic zirconium gels are basic zirconium-amino acid compounds, particularly basic zirconium glycinates, and the compounds are preferably added to aluminum-zirconium systems in the form of a wet gel. The preferred basic zirconium glycinate is formed by first reacting sodium carbonate with glycine, and then reacting the resulting sodium glycinate with a zirconium oxy or zirconium hydroxy compound to precipitate out the zirconium basic glycinate gel. The various complexes of the invention may be used in conventional antiperspirant forms, including aqueous solutions, aerosol sprays, powder-in-oil aerosol sprays, creams, lotions, cream sticks, etc.
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