6000-44-8

Basic information

• Product Name: SODIUM GLYCINATE
• Synonyms: AMINODIACETIC ACID SODIUM SALT;AMINOETHANOIC ACID SODIUM SALT;AMINOACETIC ACID SODIUM SALT;GLYCINE SODIUM SALT;GLYCOCOLL SODIUM SALT;SODIUM AMINOACETATE;SODIUM GLYCINATE;Glycine,monosodiumsalt
• CAS NO: 6000-44-8
• Molecular Formula: C₂H₄NO₂*Na
• Molecular Weight: 97.05
• EINECS: 227-842-3
• Product Categories: Food and Feed Additive
• Mol File: 6000-44-8.mol

Chemical Properties

• Boiling Point: 240.9 °C at 760 mmHg
• Flash Point: 99.5 °C
• Appearance: White to yellow/Moist Beads
• Density: 1.014g/cm3
• Vapor Pressure: 5.55E-05mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.3[at 20 ℃]
• CAS DataBase Reference: SODIUM GLYCINATE(CAS DataBase Reference)
• NIST Chemistry Reference: SODIUM GLYCINATE(6000-44-8)
• EPA Substance Registry System: SODIUM GLYCINATE(6000-44-8)

Safety Data

• RTECS: MC1100000
• Hazardous Substances Data: 6000-44-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
SODIUM GLYCINATE is used as a research chemical for its ability to inhibit spinal cord neurotransmitters and act as an allosteric regulator of NMDA receptors. This makes it a valuable compound in the study and development of treatments for various neurological conditions.
Used in Nutritional Supplements:
SODIUM GLYCINATE is used as a nutrient supplement due to its therapeutic properties. As a non-essential amino acid, it contributes to overall health and well-being, particularly in individuals with specific dietary needs or those looking to enhance their nutritional intake.
Used in Silk Fibroin Production:
SODIUM GLYCINATE, being a primary component of silk fibroin, is used in the production of silk-based materials. Its presence in silk fibroin contributes to the unique properties of silk, such as its strength, flexibility, and biocompatibility, making it an essential component in the textile and biotechnology industries.
Used in Food Industry:
SODIUM GLYCINATE is used as a flavor enhancer and a nutrient in the food industry. Its ability to improve the taste and texture of various food products makes it a valuable additive in the development of new and improved food items.
Used in Cosmetics Industry:
SODIUM GLYCINATE is used as a skin conditioning agent in the cosmetics industry. Its moisturizing and nourishing properties make it an ideal ingredient for skincare products, helping to maintain skin health and appearance.

InChI:InChI=1/C16H24FNO/c1-3-15(2)12-16(8-10-18,9-11-19-15)13-4-6-14(17)7-5-13/h4-7H,3,8-12,18H2,1-2H3

Upstream product

• 56-40-6 glycine 
• 51514-20-6 Sodium; ((Z)-2-ethoxycarbonyl-1-methyl-vinylamino)-acetate 
• 141-43-5 ethanolamine 
• 7699-43-6 zirconyl chloride 
• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 459-73-4 GlyOEt*HCl 
• 111-42-2 2,2'-iminobis[ethanol] 

Downstream Products

• 95-99-8 N,N'-bis(carboxymethyl)dithiooxamide 
• 500-98-1 phenylacetylglycine 
• 120037-23-2 N-(2-phenyl-oxazol-4-ylcarbamoyl)-glycine 
• 118807-77-5 N-(3-nitro-2-pyridyl)-α-glycine 
• 389070-77-3 N-(benzenesulfonyl)glycylglycine 
• 25616-33-5 2-((2S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)acetic acid 
• 128398-52-7 3-(benzoylamino)-2,5,6,7,8-hexahydro-8,8-dimethyl-2,5-dioxo-1H-pyrido<3,2-c>azepine-1-acetic acid 
• 128398-47-0 3-(Benzoylamino)-5,6,7,8-tetrahydro-7,7-dimethyl-2,5-dioxo-1(2H)-quinolineacetic acid 
• 74471-69-5 N-(4-methoxy-benzylidene)-glycine; sodium salt 
• 80687-40-7 Sodium; (bis-phenylsulfanylmethyl-amino)-acetate 
• 87650-99-5 [6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydrofuran-2-yl)-9H-purin-8-ylamino]-acetic acid 
• 6974-78-3 8-bromoadenine 
• 14246-55-0 N-myristoylglycine 
• 6333-54-6 N-stearoylglycine 

Relevant articles and documents

Study on the Structure of Cu/ZrO2 Catalyst and the Formation Mechanism of Disodium Iminodiacetate and Sodium Glycine

Abstract: A new method to prepare Cu/ZrO2 catalysts by reducing CuO/ZrO2 with hydrazine hydrate is reported, and the prepared catalysts were used to synthesize disodium iminodiacetate by diethanolamine dehydrogenation. Hydrazine hydrate can rapidly reduce the CuO/ZrO2 precursor powder in an alkaline environment at a moderate temperature. The ratio of Cu0/Cu+ at the Cu/ZrO2 surface was controlled by the amount of hydrazine hydrate and the reduction reaction time. The formation mechanism of disodium glycine as the main byproduct and iminodiacetate were deduced by investigating the product yield, the reaction time, and the presence of acetaldehyde in the evolved gas. It has been shown that the ratio of Cu0/Cu+ in Cu/ZrO2 significantly affects the dehydrogenation of diethanolamine into disodium iminodiacetate. Cu0 and Cu+ are the catalytic activity centers in the dehydrogenation of diethanolamine which respectively produce intermediate aldehydes and an ester via nucleophilic addition reactions. The formation mechanism of sodium glycinate is related to the tautomerism of intermediate products and Schiff base hydrolysis. Graphic Abstract: The formation mechanism of disodium iminodiacetate and sodium glycine producing by the dehydrogenation of diethanolamine over the Cu/ZrO2 catalysts which were prepared by a new reduction method.

A bio-based benzoxazine surfactant from amino acids

A novel bio-based benzoxazine (Ca-g) surfactant was synthesizedviaa Mannich reaction using renewable glycine and cardanol as raw materials. The structure of Ca-g was characterized by NMR, FT-IR, and elemental analysis. Styrene containing emulsions and polystyrene (PS) latex were prepared based on the Ca-g surfactant. These results showed that the Ca-g surfactant exhibited high efficiency for stabilizing styrene emulsions. An addition of only 1.7 (w/v)% stabilized the high internal phase emulsion (HIPE) with a styrene volume fraction up to 90%. More interestingly, HIPE exhibited pH-sensitivity and could be formed at pH values from 9.0 to 12.0. Furthermore, PS particles were obtainedviaHIPE polymerization. In addition, thein vitrocytotoxicity of Ca-g and its triglyceride emulsion was also investigated. Ca-g showed lower cytotoxicity against the HeLa cell line. A stable triglyceride-in-water emulsion stabilized by Ca-g was prepared. The bio-based Ca-g surfactant may have potential use in cosmetics and daily cleaning products.

Synthesis, characterization, DNA and HSA binding studies of isomeric Pd (II) antitumor complexes using spectrophotometry techniques

Two new Palladium(II) isomeric complexes, [Pd (Gly)(Leu)](I) and [Pd (Gly)(Ile)](II), where Gly is glycine, and Leu and Ile are isomeric amino acids (leucine and isoleucine), have been synthesized and characterized by elemental analysis, molar conductivity measurements, FT-IR, 1H NMR, and UV–Vis. The complexes have been tested for their In vitro cytotoxicity against cancer cell line K562 and their binding properties to calf thymus DNA (CT-DNA) and human serum albumin (HSA) have also been investigated by multispectroscopic techniques. Interactions of these complexes with CT-DNA were monitored using gel electrophoresis. The energy transfer from HSA to these complexes and the binding distance between HSA and the complexes (r) were calculated. The results obtained from these studies indicated that at very low concentrations, both complexes effectively interact with CT-DNA and HSA. Fluorescence studies revealed that the complexes strongly quench DNA bound ethidium bromide as well as the intrinsic fluorescence of HSA through the static quenching procedures. Binding constant (Kb), apparent biomolecular quenching constant (kq), and number of binding sites (n) for CT-DNA and HSA were calculated using Stern–Volmer equation. The calculated thermodynamic parameters indicated that the hydrogen binding and vander Waals forces might play a major role in the interaction of these complexes with HSA and DNA. Thus, we propose that the complexes exhibit the groove binding with CT-DNA and interact with the main binding pocket of HSA. The complexes follow the binding affinity order of I?>?II with DNA- and II?>?I with HSA-binding.

MANUFACTURING METHOD OF AMINOCARBOXYLIC ACID SALT

PROBLEM TO BE SOLVED: To provide a manufacturing method of aminocarboxylic acid salt capable of suppressing and inhibiting generation of fastening of a coloring component in a reaction liquid containing the aminocarboxylic acid salt manufactured by oxidation dehydrogenation of amino alcohol in the presence of a copper-containing catalyst or capable of suppressing and inhibiting production of precipitate during manufacturing the aminocarboxylic acid from aminocarboxylic acid salt. SOLUTION: There is provided a manufacturing method for aminocarboxylic acid salt including oxidation dehydrogenation of amino alcohol in the presence of a copper-containing catalyst to obtain a reaction product and removing the copper-containing catalyst from the reaction product to obtain a reaction liquid containing aminocarboxylic acid salt having limitation of the total content (in terms of metals) of silicon (Si), aluminum (Al) and iron (Fe) to 100 mass.ppm or less. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

RUTHENIUM COMPLEXES AND THEIR USES AS CATALYSTS IN PROCESSES FOR FORMATION AND/OR HYDROGENATION OF ESTERS, AMIDES AND RELATED REACTIONS

The present invention relates to novel Ruthenium complexes of formulae A1-A4 and their use, inter alia, for (1) dehydrogenative coupling of alcohols to esters; (2) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (3) preparing amides from alcohols and amines—(including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or polymerization of amino alcohols and/or forming cyclic dipeptides from p-aminoalcohols; (4) hydrogenation of amides (including cyclic dipeptides, polypeptides and polyamides) to alcohols and amines; (5) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (6) dehydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e., synthesis of amides from esters and amines); (8) acylation of alcohols using esters; (9) coupling of alcohols with water and a base to form carboxylic acids; and (10) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. The present, invention further relates to the use of certain known Ruthenium complexes for the preparation of amino acids or their salts from amino alcohols.

General Synthesis of Amino Acid Salts from Amino Alcohols and Basic Water Liberating H2

An atom-economical and environmentally friendly method to transform amino alcohols to amino acid salts using just basic water, without the need of pre-protection or added oxidant, catalyzed by a ruthenium pincer complex, is developed. Water is the solvent, the source of the oxygen atom of the carboxylic acid group, and the actual oxidant, with liberation of dihydrogen. Many important and useful natural and unnatural amino acid salts can be produced in excellent yields by applying this new method.

AMINO ACID SALT CONTAINING COMPOSITIONS

A reagent composition for forming fatty acyl amido surfactants is provided which includes an alkali metal or alkaline earth metal salt of an amino compound; a polyol of molecular weight ranging from 76 to 300; and no more than 10% water.

Equimolar CO2 capture by N-substituted amino acid salts and subsequent conversion

Steric bulk controls CO2 absorption: N-substituted amino acid salts in poly(ethylene glycol) reversibly absorb CO2 in nearly 1:1 stoichiometry. Carbamic acid is thought to be the absorbed form of CO 2; this was supported by NMR and in situ IR spectroscopy, and DFT calculations. The captured CO2 could be converted directly into oxazolidinones and thus CO2 desorption could be sidestepped. Copyright

Hydration of amino acids from ultrasonic measurements

In this paper the results of compressibility of aqueous solutions of amino acids in water and in aqueous HCl and NaOH solutions at 25 °C are presented. The effect of the charged protonated amino groups and deprotonated carboxylic groups on the hydration number was tested. The idea of additivity of the hydration number with the constituents of the solute molecule was successfully applied and discussed.

Process for Preparing Creatine, Creatine Monohydrate or Guanidinoacetic Acid

A process for producing creatine, creatine monohydrate or guanidinoacetic acid is proposed, wherein firstly N-methylethanolamine or ethanolamine is catalytically dehydrogenated in each case in alkaline solution and the sarcosinate or glycinate solutions that are obtained in this manner are finally reacted under acidic conditions with a guanylating agent such as for example O-alkylisourea or cyanamide. In this manner products are obtained in high yields and very good purity where in contrast to the prior art no traces whatsoever of hydrocyanic acid, formaldehyde, chloroacetic acid or ammonia are present. The formation of the toxicologically critical dihydrotriazine is also avoided.