603126-57-4

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 1501-04-8 Methyl 4-benzoylbutanoate 
• 10413-00-0 5-oxo-5-phenylpentanenitrile 
• 5415-48-5 2-benzoyl-4-cyano-butyric acid ethyl ester 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 1501-05-9 5-oxo-5-phenylvaleric acid 
• 870262-27-4 1-imidazol-1-yl-5-phenyl-pentane-1,5-dione 

Downstream Products

• 40297-30-1 2-Hydroxy-2-phenylcyclopentan-1-one 
• 1198-34-1 2-Phenylcyclopentanone 

Relevant academic research and scientific papers

Enantioselective titanium(III)-catalyzed reductive cyclization of ketonitriles

Reduction, please! The title reaction affords ?-hydroxyketones, a common structural motif in biologically active natural products, in good yields and high enantioselectivities at room temperature. The commercially available ansa-titanocene 1 was found to be an efficient catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile.

Mg-promoted facile and selective intramolecular cyclization of aromatic δ-ketoesters

Treatment of various types of aromatic δ-ketoesters 2, 7, and 9 with Mg-turnings for Grignard reaction at -5 to 0 °C in N,N-dimethylformamide (DMF) containing trimethylsilyl chloride (TMSCl) brought about selective and reductive intramolecular cyclization

Electroreductive acylation of aromatic ketones with acylimidazoles

The intermolecular reductive coupling of aromatic ketones with acylimidazoles was effected by electroreduction in the presence of chlorotrimethylsilane and gave α-trimethylsiloxy ketones and esters. The best result was obtained using Bu4NPF6 as a supporting electrolyte and a Pb cathode in THF. The α-trimethylsiloxy-containing products were transformed to the corresponding α-hydroxy ketones and esters by treatment with TBAF in THF. This method was also effective for the intramolecular reductive coupling of δ- and ε-keto acylimidazoles.

Electroreductive intramolecular coupling of aromatic δ- and ε-keto esters

Electroreduction of aromatic δ- and ε-keto esters in the presence of chlorotrimethylsilane and triethylamine gave five- and six-membered cyclized products. The products were transformed to the corresponding α-hydroxy ketones.