60811-17-8

Basic information

• Product Name: 5-BROMO-2-CHLOROANILINE
• Synonyms: 2-CHLORO-5-BROMOANILINE;3-BROMO-6-CHLOROANILINE;5-BROMO-2-CHLOROANILINE;5-BROMO-2-CHLORO-ANILINE >98%;5-broMo-2-chloro-benzenaMine
• CAS NO: 60811-17-8
• Molecular Formula: C₆H₅BrClN
• Molecular Weight: 206.47
• Mol File: 60811-17-8.mol

Chemical Properties

• Melting Point: 48 °C
• Boiling Point: 0°C
• Flash Point: 0°C
• Appearance: /Solid
• Density: 1.722 g/cm³
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.638
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.58±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-BROMO-2-CHLOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-CHLOROANILINE(60811-17-8)
• EPA Substance Registry System: 5-BROMO-2-CHLOROANILINE(60811-17-8)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 24/25
• RIDADR: 2811
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 60811-17-8(Hazardous Substances Data)

Usage

Uses

Used in Agrochemical Industry:
5-Bromo-2-chloroaniline is used as an important raw material and intermediate for the development of agrochemicals. It plays a crucial role in the production of pesticides and other chemicals that help protect crops from pests and diseases, ensuring a stable food supply.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 5-bromo-2-chloroaniline serves as a key intermediate in the synthesis of various drugs. Its unique chemical properties allow it to be incorporated into the molecular structures of medications, potentially enhancing their efficacy and targeting specific health conditions.
Used in Dyestuff Industry:
5-Bromo-2-chloroaniline is also utilized in the dyestuff industry as a vital component in the creation of synthetic dyes. These dyes are used in a wide range of applications, from textiles and fabrics to various industrial processes, providing vibrant colors and enhancing the visual appeal of products.

InChI:InChI=1/C6H5BrClN/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2

Upstream product

• 591-19-5 m-Bromoaniline 
• 16588-24-2 4-bromo-1-chloro-2-nitrobenzene 
• 7439-89-6 iron 
• 635-22-3 4-Chloro-3-nitroaniline 
• 112160-74-4 acetic acid-(2,4,N-trichloro-anilide) 
• 106-40-1 4-bromo-aniline 
• 67-66-3 chloroform 

Downstream Products

• 1253380-27-6 1-(5-bromo-2-chlorophenyl)-4-[(2-chloro-4-fluorophenyl)methyl]-2,3-piperazinedione 

Relevant articles and documents

Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst

We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective catalyst, with a catalyst loading as low as 1%. The new catalytic system also allowed us to extend this chemistry to obtain excellent ortho-selectivities for unprotected anilines. The selectivities of this reaction are up to >20:1 ortho/para, while the innate selectivities for phenols and anilines are approximately 1:4 ortho/para. A series of preliminary studies revealed that the substrates require a hydrogen-bonding moiety for selectivity.

Substituted piperazines

Compounds are provided that act as potent antagonists of the CCR1 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR1. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

Thiazolidine derivatives

The invention relates to thiazolidine derivatives having in 4-position a hydroxy group and a 3'-sulphamyl-phenyl substituent, in 2-position an imino group and in 1-position an aliphatic or cycloaliphatic substituent. Said thiazolidines have diuretic activity. The invention also relates to a process for the manufacture of said compounds.