622369-21-5

Basic information

• Product Name: 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[(1-METHYL-4-PIPERIDIN-4-YL)METHOXY]-3 QUINOLINECARBONITRILE
• Synonyms: 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[(1-METHYL-4-PIPERIDIN-4-YL)METHOXY]-3 QUINOLINECARBONITRILE;4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[(1-METHYL-4-PIPERIDINYL)METHOXY]-3 QUINOLINECARBONITRILE
• CAS NO: 622369-21-5
• Molecular Formula: C27H30Cl2N4O3
• Molecular Weight: 529.46
• Mol File: 622369-21-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 622.5°C at 760 mmHg
• Flash Point: 330.3°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 2.03E-15mmHg at 25°C
• Refractive Index: 1.634
• PKA: 9.50±0.10(Predicted)
• CAS DataBase Reference: 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[(1-METHYL-4-PIPERIDIN-4-YL)METHOXY]-3 QUINOLINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[(1-METHYL-4-PIPERIDIN-4-YL)METHOXY]-3 QUINOLINECARBONITRILE(622369-21-5)
• EPA Substance Registry System: 4-[(2,4-DICHLORO-5-METHOXYPHENYL)AMINO]-6-METHOXY-7-[(1-METHYL-4-PIPERIDIN-4-YL)METHOXY]-3 QUINOLINECARBONITRILE(622369-21-5)

Safety Data

• Hazardous Substances Data: 622369-21-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C27H30Cl2N4O3/c1-33-8-6-17(7-9-33)5-4-10-36-26-13-22-19(11-25(26)35-3)27(18(15-30)16-31-22)32-23-14-24(34-2)21(29)12-20(23)28/h11-14,16-17H,4-10H2,1-3H3,(H,31,32)

Upstream product

• 7037-30-1 3-(1-methylpiperidin-4-yl)propan-1-ol 
• 622369-38-4 7-fluoro-6-methoxy-4-oxo-1,4-dihydro-3-quinolinecarbonitrile 
• 622369-40-8 4-chloro-6-methoxy-7-fluoro-quinoline-3-carbonitrile 
• 98446-49-2 2,4-dichloro-5-methoxyaniline 
• 366-99-4 3-fluoro-4-methoxyaniline 
• 622369-46-4 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 263149-10-6 4-chloro-7-hydroxy-6-methoxyquinolin-3-carbonitrile 

Relevant articles and documents

TREATMENT OF IMATINIB RESISTANT LEUKEMIA

The present invention provides 4-anilino-3-quinolinecarbonitriles compounds useful for treating a subject having an BcrAbl positive leukemia that is resistant to imatinib.

4-ANILINO-3-QUINOLINECARBONITRILES FOR THE TREATMENT OF CHRONIC MYELOGENOUS LEUKEMIA (CML)

Compounds of the formula (I): wherein: n is an integer from 0-3; X is N, CH; R is alkyl of 1 to 3 carbon atoms; R' is 2,4-diCl, 5-OMe in para, ortho, or meta position; 2,4-diCl in para position; 3,4,5-tri-OMe in para position; 2-Cl, 5-OMe in para position

Process for the preparation of 7-substituted-3 quinolinecarbonitriles

There is provided a process for the preparation of 7-substituted-3-quinolinecarbonitriles and intermediates useful in a process to prepare 7-substituted-3-quinolinecarbonitriles and pharmaceutically acceptable salts is described. Where 7-fluoro-4-oxo-1,4-