622369-26-0

Basic information

• Product Name: 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidin-2-yl)methoxy]quinoline-3-carbonitrile
• CAS NO: 622369-26-0
• Molecular Formula: C₂₅H₂₆Cl₂N₄O₃
• Molecular Weight: 501.4049
• Mol File: 622369-26-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 603.6°C at 760 mmHg
• Flash Point: 318.8°C
• Density: 1.36g/cm³
• Vapor Pressure: 1.6E-14mmHg at 25°C
• Refractive Index: 1.647
• CAS DataBase Reference: 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidin-2-yl)methoxy]quinoline-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidin-2-yl)methoxy]quinoline-3-carbonitrile(622369-26-0)
• EPA Substance Registry System: 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidin-2-yl)methoxy]quinoline-3-carbonitrile(622369-26-0)

Safety Data

• Hazardous Substances Data: 622369-26-0(Hazardous Substances Data)

Upstream product

• 98446-49-2 2,4-dichloro-5-methoxyaniline 
• 366-99-4 3-fluoro-4-methoxyaniline 
• 20845-34-5 (1-methyl-piperidin-2-yl)-methanol 
• 622369-46-4 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile 
• 622369-38-4 7-fluoro-6-methoxy-4-oxo-1,4-dihydro-3-quinolinecarbonitrile 
• 622369-40-8 4-chloro-6-methoxy-7-fluoro-quinoline-3-carbonitrile 

Relevant articles and documents

7-Alkoxy-4-phenylamino-3-quinolinecarbonitriles as Dual Inhibitors of Src and Abl Kinases

We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kina