63002-70-0

Basic information

• Product Name: 3-amino-2-(4-chlorophenyl)-3,4-dihydroquinazolin-4-one
• Synonyms: 3-amino-2-(4-chlorophenyl)-3,4-dihydroquinazolin-4-one;3-AMINO-2-(4-CHLOROPHENYL)QUINAZOLIN-4(3H)-ONE
• CAS NO: 63002-70-0
• Molecular Formula: C₁₄H₁₀ClN₃O
• Molecular Weight: 271.7017
• Mol File: 63002-70-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-amino-2-(4-chlorophenyl)-3,4-dihydroquinazolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-2-(4-chlorophenyl)-3,4-dihydroquinazolin-4-one(63002-70-0)
• EPA Substance Registry System: 3-amino-2-(4-chlorophenyl)-3,4-dihydroquinazolin-4-one(63002-70-0)

Safety Data

• Hazardous Substances Data: 63002-70-0(Hazardous Substances Data)

Upstream product

• 18600-52-7 2-(4-chlorophenyl)-4H-benzo[d][1,3]oxazin-4-one 
• 104830-73-1 4-chloro-N-(2-hydrazinocarbonyl-phenyl)benzamide 
• 35141-49-2 2-(4-chlorophenyl)-2,3-dihydrobenzo[e][1,3]oxazin-4-one 
• 118-92-3 anthranilic acid 
• 122-01-0 4-chloro-benzoyl chloride 

Downstream Products

• 7455-77-8 2-(4-chlorophenyl)-4(3H)-quinazolinone 
• 942031-34-7 C₁₆H₁₁Cl₂N₃O₂ 
• 1228146-46-0 C₂₃H₁₅ClN₆O₃S 
• 1228146-49-3 C₂₄H₁₆ClN₅O₃S 
• 1414886-77-3 2-(4-chlorophenyl)-3-{[(3-(pyridin-4-yl)-1-(p-tolyl)-1H-pyrazol-4-yl)methylene]amino}quinazolin-4(3H)-one 

Relevant articles and documents

Quinazolinone-schiff's base hybrids as phosphodiesterase 4b inhibitors with dual activity against COPD and lung cancer

A series of thirty compounds of quinazolinone-Schiff's base hybrids were rationally designed, synthesized, and evaluated for their in vitro Phosphodiesterase 4B inhibition, anti-lung and anti-colon cancer activities. Compounds 9, 16, 23, 29, 30, 31, 32 an

Synthesis of some N-(4-oxo-2-sustitutedphenylquinazolin-3-(4H)-yl)-2-[(5- aryl-1,3.4-oxadiazol-2-yl) sulfanyl] acetamides as antitubercular agents

A series of some N-(4-oxo-2-substituted phenylquinazolin-3-(4H)-yl)-2-[(5- aryl-1,3,4-oxadiazol-2-yl) sulfanyl] acetamides 5 were synthesized and characterized on the basis of IR, NMR and mass spectral data. The title compounds were subjected to in-vitro

Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases

A combinatorial series of novel quinazolin-4(3H)-ones were synthesised and their structures were established based on spectroscopic data (IR, NMR, EI-MS, and FAB-MS). The compounds were tested for inhibition of the zinc metalloproteinase thermolysin (TLN) utilizing a chemical array-based approach. Some of the compounds were found to inhibit TLN, with IC50 values ranging from 0.0115 μM (compound 3) to 122,637 μM (compound 29). Compound 3 [3-phenyl-2-(trifluoromethyl) quinazolin-4(3H)-one] (IC50 = 0.0115 μM) and compound 35 [3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4 (1H)-one] (IC50 = 0.2477 μM) were found to be the most potent inhibitors.

Reaction of 2-Aryl-3,1-benzoxazine-4-ones with Hydrazine Hydrate: A Reinvestigation

The reaction of 2-aryl-3,1-benzoxazine-4-ones (I) and hydrazine hydrate in refluxing xylene yields 2-aryl-3-aminoquinazolin-4(3H)-ones (III), instead of 2-aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones (II).III is also obtained by treating I with hydrazi

A New Synthesis of 2-Aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones

The reaction of 2-aryl-3,1-benzoxazine-4-ones (1) and hydrazine hydrate in refluxing xylene yields 2-aryl-3,4-dihydro-5H-1,3,4-benzotriazepin-5-ones in 55-74percent yield.In basic conditions this reaction, however, gives 2-aryl-3-aminoquinazolin-4(3H)-one