6339-93-1

Basic information

• Product Name: 1,2-dipyridin-3-ylethanone
• Synonyms: 1,2-dipyridin-3-ylethanone
• CAS NO: 6339-93-1
• Molecular Formula: C₁₂H₁₀N₂O
• Molecular Weight: 198.22
• Mol File: 6339-93-1.mol

Chemical Properties

• Boiling Point: 384.2°C at 760 mmHg
• Flash Point: 189.2°C
• Appearance: /
• Density: 1.179g/cm³
• Vapor Pressure: 4.17E-06mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 1,2-dipyridin-3-ylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dipyridin-3-ylethanone(6339-93-1)
• EPA Substance Registry System: 1,2-dipyridin-3-ylethanone(6339-93-1)

Safety Data

• Hazardous Substances Data: 6339-93-1(Hazardous Substances Data)

Usage

Physical state

Yellow colored solid

Usage

Flavoring agent and fragrance ingredient

Applications

Production of food and beverage products, perfumes, and cosmetics

Synthesis

Used in the synthesis of pharmaceuticals and other organic compounds

Toxicity

Low-toxicity compound

Irritation potential

Mild

Regulation

Regulated for safe usage in various consumer products

InChI:InChI=1/C12H10N2O/c15-12(11-4-2-6-14-9-11)7-10-3-1-5-13-8-10/h1-6,8-9H,7H2

Upstream product

• 50559-45-0 3-(2-(pyridin-3-yl)ethynyl)pyridine 
• 1120-90-7 3-iodopyridine 
• 350-03-8 methyl-3-pyridylketone 
• 626-60-8 3-Chloropyridine 
• 108-99-6 3-Methylpyridine 

Downstream Products

• 59-67-6 nicotinic acid 

Relevant articles and documents

Photoinduced direct hydration of dipyridylacetylenes in acidic aqueous solution

Photoinduced direct hydration of dipyridylacetylenes (DPAs) in acidic aqueous solution was achieved upon UV irradiation at room temperature. This is a catalyst-free reaction with moderate-to-good yields, and asymmetric dipyridylacetylenes afford the corresponding Markovnikov addition products.

Palladium-Catalyzed Direct α-C(sp3) Heteroarylation of Ketones under Microwave Irradiation

Heteroaryl compounds are valuable building blocks in medicinal chemistry and chemical industry. A palladium-catalyzed direct α-C(sp3) heteroarylation of ketones under microwave irradiation is developed and reported in this study. Under optimized condition

NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME

The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the precatalysts of the invention are air-stable and moisture-stable. The present invention further provides methods of making and using the precatalysts of the invention.

Design of a versatile and improved precatalyst scaffold for palladium-catalyzed cross-coupling: (η3-1-tBu-indenyl)2(μ-Cl)2Pd2

We describe the development of (η3-1-tBu-indenyl)2(μ-Cl)2Pd2, a versatile precatalyst scaffold for Pd-catalyzed cross-coupling. Our new system is more active than commercially available (η3-cinnamyl)2(μ-Cl)2Pd2 and is compatible with a range of NHC and phosphine ligands. Precatalysts of the type (η3-1-tBu-indenyl)Pd(Cl)(L) can either be isolated through the reaction of (η3-1-tBu-indenyl)2(μ-Cl)2Pd2 with the appropriate ligand or generated in situ, which offers advantages for ligand screening. We show that the (η3-1-tBu-indenyl)2(μ-Cl)2Pd2 scaffold generates highly active systems for a number of challenging cross-coupling reactions. The reason for the improved catalytic activity of systems generated from the (η3-1-tBu-indenyl)2(μ-Cl)2Pd2 scaffold compared to (η3-cinnamyl)2(μ-Cl)2Pd2 is that inactive PdI dimers are not formed during catalysis.

Selective monoarylation of acetate esters and aryl methyl ketones using aryl chlorides

Simple, efficient procedures for the monoarylation of acetate esters and aryl methyl ketones using aryl chlorides are presented. Previously, no general method was available to ensure the highly selective monoarylation of these classes of substrates using