6642-30-4Relevant articles and documents
Quantum-chemical study of thermodynamics of hydrogen-bonded methylamine-methanol complexes reaction with dimethyl carbonate
Samuilov,Balabanova,Samuilov,Konovalov
, (2014)
Thermodynamic parameters of the reactions of dimethyl carbonate cis-cis and cis-trans conformers with methylamine, methylamine dimer, and methylamine complexes involving linear methanol associates have been computed with the B3LYP and WB97XD quantum-chemi
CANNABINOID DERIVATIVES
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Paragraph 0159; 0173, (2021/04/10)
This disclosure relates to carmabinoid derivatives of Formula (1) wherein R4 or R7 is a carboxamide group, pharmaceutical compositions comprising these compounds and methods of using the carmabinoid derivatives. These compounds are potential carmabinoid receptor inhibitors, including CB1 and CB2 receptors. Formula (I)
CANNABINOID DERIVATIVES
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Paragraph 0147-0148, (2021/06/04)
This disclosure relates generally to cannabinoid derivatives having the structural formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives. In some embodiments, R1 is - CH2CH=C(CH3)2, R2 is methyl, R3 is CsHn, R4 is -C(O)N(R4a)(R4b), R5 is H, R6 is OH, and R7 is H. Compounds of the present disclosure were tested in agonist and antagonist mode for both the CB1 and CB2 receptors. The tested compounds were generally found to exhibit activity in antagonist mode at the CB1 and CB2 receptor.
CANNABINOID DERIVATIVES
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Paragraph 0136, (2021/06/22)
This disclosure relates generally to cannabinoid derivatives, pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives.
A preparation method of a dog or CAT
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Paragraph 0011; 0028-0030, (2019/03/29)
The invention discloses a dog or CAT a kind of preparation method. Characterized in that (1) in order to inter-bromobenzene as the starting material, nitric acid/sulfuric acid system through the nitration reaction, process for preparing the intermediate 1 (2, 4 - dibromo nitrobenzene); (2) using the intermediate 1 as raw materials, through the ammonia in methanol solution of ammoniation reaction, to prepare the intermediate 2 (5 - bromo - 2 - nitroaniline); (3) using the intermediate 2 and thiophenol sodium solution as raw materials, through the condensation reaction, process for preparing the intermediate 3 (4 - phenylthio - 2 - nitroaniline); (4) intermediate 3 through the palladium catalytic hydrogenation reduction, to produce intermediate 4 (4 - phenylthio - 1, 2 - phenylenediamine); (5) intermediate 4 and melamine-based methyl formate solution, through the cyclization reaction, the profuse benzene reaches zuo generating products. The method clean environment, the production cost is low, with a purity of 99.5% or more, the yield is not lower than 84.0%.
Synthesis of dimethyl carbonate from methanol and urea over zinc-strontia mixed oxide catalysts
D., Dhana Lakshmi,B., Srinivasa Rao,Lingaiah
, p. 1 - 4 (2019/01/16)
A series of ZnO-SrO mixed oxide catalysts were prepared by co-precipitation with different compositions and tested for dimethyl carbonate synthesis from urea and methanol. The catalysts were characterized by BET surface area, XRD, NH3-TPD and CO2-TPD. The catalyst with 1:1 mol ratio exhibited high DMC yield of 35%. The uniform distributions of moderate to strong basic sites along with considerable number of acidic sites are accountable for high activity. Different reaction parameters were also screened and best possible conditions were established. The catalyst was easily recovered and reused with consistent activity.
La-modified mesoporous Mg-Al mixed oxides: Effective and stable base catalysts for the synthesis of dimethyl carbonate from methyl carbamate and methanol
Wang, Dengfeng,Zhang, Xuelan,Ma, Jie,Yu, Haiwen,Shen, Jingzhu,Wei, Wei
, p. 1530 - 1545 (2016/03/09)
A series of La-containing Mg-Al hydrotalcite-like (HTl) precursors with different La contents (Mg2+:Al3+:La3+ = 3:1:x, where x varies from 0 to 1.0) were synthesized using a co-precipitation method followed by hydrothermal treatment. X-ray diffraction and thermogravimetric measurements demonstrated that the yield of the HTl phase decreased with increasing La content. The La-modified Mg-Al mixed oxides (HTC-La) were then obtained by thermal decomposition of the corresponding HTl precursors, and the mesoporous structure was formed during calcination. It was demonstrated that the structure and surface basic properties of the HTC-La samples strongly depended on the amount of La additive. Simultaneously, the resulting HTC-La materials were used as solid base catalysts for the synthesis of dimethyl carbonate (DMC) from methyl carbamate (MC) and methanol. Then, the correlation between their basic properties and catalytic performance was studied in detail. The incorporation of a suitable amount of La into HTC-La catalysts was beneficial for the production of DMC, and a DMC yield of 54.3% with a high DMC selectivity of 80.9% could be achieved when x was tuned to 0.5 under the optimized reaction conditions. In addition, the HTC-La catalyst could be readily recycled while maintaining high catalytic activity and selectivity for DMC. Furthermore, in situ FTIR experiments were carried out to elucidate the adsorption behaviours of the reactants. On the basis of the experimental results, a plausible basic catalytic mechanism wherein MC and methanol were activated simultaneously on the basic sites of the catalyst was proposed for this catalytic reaction.
Catalytic alcoholysis of urea to diethyl carbonate over calcined Mg-Zn-Al hydrotalcite
Wang, Peixue,Liu, Shimin,Zhou, Feng,Yang, Benqun,Alshammari, Ahmad S.,Deng, Youquan
, p. 19534 - 19540 (2015/06/15)
The synthesis of diethyl carbonate (DEC) from urea and ethanol was carried out over Mg-Zn-Al composite oxide catalysts derived from hydrotalcites (HTs). The catalytic results showed that the ternary hydrotalcites calcined at 450 °C with Mg:Zn:Al = 1:1.7:1 exhibited superior catalytic activity, and the highest DEC yield was 67.8%. Similar to ethanol, other alcohols such as methanol and butanol can also be transformed to corresponding dialkyl carbonates. Catalysts were characterized by XRD, BET, SEM and TPD with the aim of establishing a relationship between performance and structure. The results indicated that MgZn1.7Al-450 with nanoplate morphology and more accessible active medium basic sites were favourable for obtaining much superior catalytic activity. Recycling experiments demonstrated that the catalyst could be successfully reused. This journal is
AN IMPROVED PROCESS FOR THE PREPARATION OF DIMETHYL CARBONATE USING IONIC LIQUIDS AS CATALYST
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Paragraph 0035, (2015/06/25)
The present invention relates to an improved process for the preparation of dimethyl carbonate and methyl-N-methyl carbamate starting from methanol and methyl carbamate catalyzed by ionic liquid catalyst in batch or continuous reactor.
PROCESS FOR THE SYNTHESIS OF DIMETHYLCARBONATE
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Page/Page column 11, (2015/11/02)
The present invention discloses a process for the synthesis of dimethyl carbonate (DMC) and further methyl-N-methyl carbamate (MNMC) starting from urea or methyl carbamate using salts such as nitrate or triflate salts of rare earth elements, transition metals, alkaline earth and alkali metals as catalysts.
