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69-23-8

Articles about 69-23-8Total 3 be found

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Potential CNS antitumor agents - Phenothiazines. II: Fluphenazine analogs
Fluphenazine was found to possess moderate, reproducible activity against the intraperitoneal L-1210 and P-388 leukemia murine tumor models. Seven ether derivatives of fluphenazine and eight compounds in which the terminal side-chain hydroxyl group was replaced by an amine function were prepared and evaluated in the intraperitoneal L-1210, P-388, and B16 melanoma systems as well as the intracerebral L-1210 and ependymoblastoma brain tumor models. While no substantial intracerebral activity was observed, seven derivatives possessed reproducible activity in the intraperitoneal L-1210 or P-388 system. Several gave T/C [(treated survival/control survival) x 100%] values of 150%. No B16 melanoma activity was observed. These compounds were also tested for their cytototoxic properties in culture against L-1210, P-388, and KB cells. The amine isosteres, while possessing little in vivo activity, were the most cytotoxic of the compounds prepared, with several having ED50 values 1 μg/ml.
Hirata,Peng,Driscoll
p. 157 - 162
(2007/10/04)

Stability of some phenothiazine free radicals.
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Levy,Tozer,Tuck,Loveland
p. 898 - 905
(2007/10/10)

Synthesis of phenothiazines. VIII. 10-piperazinylalkyl dirivatives of 2-chloro- and 2-trifluoromethvlphenothiazine [1.]
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ANDERSON
p. 937 - 942
(2007/10/04)

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Chemical Properties

Appearance/Colour :white crystalline powder
Melting Point: 268-274℃
Boiling Point: 568.3°C at 760 mmHg
Flash Point:297.5°C
Density: 1.272g/cm³
Storage Temp.:?20°C
Vapor Pressure: 9.41E-14mmHg at 25°C
PKA: pKa 7.98±0.03(H2O t=20±0.5) (Uncertain)
PSA: 55.25000
LogP: 4.24890

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