7019-01-4

Basic information

• Product Name: 4-(PHENYLSULFONYL)ANILINE
• Synonyms: 4-(PHENYLSULFONYL)ANILINE;[4-(Phenylsulfonyl)phenyl]aMine;4-(Benzenesulphonyl)phenylaMine;4-AMinodiphenyl Sulfone;4-AMinophenyl Phenyl Sulfone;p-(Phenylsulfonyl)aniline;p-AMinodiphenyl Sulfone;p-AMinophenyl Phenyl Sulfone
• CAS NO: 7019-01-4
• Molecular Formula: C₁₂H₁₁NO₂S
• Molecular Weight: 233.29
• Product Categories: Amines;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 7019-01-4.mol

Chemical Properties

• Melting Point: 175-177°C
• Appearance: /
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-(PHENYLSULFONYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PHENYLSULFONYL)ANILINE(7019-01-4)
• EPA Substance Registry System: 4-(PHENYLSULFONYL)ANILINE(7019-01-4)

Safety Data

• Hazardous Substances Data: 7019-01-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(Phenylsulfonyl)aniline is used as a key intermediate in the synthesis of novel Flufenamic acid analogues. These analogues serve as inhibitors of androgen receptor-mediated transcription, which can be beneficial in the development of treatments for conditions related to androgen receptor activity, such as certain types of cancer and hormonal disorders.

Upstream product

• 1146-39-0 4-nitrophenyl phenyl sulfone 
• 21849-33-2 (4-benzenesulfonyl-phenyl)-carbamic acid ethyl ester 
• 107920-73-0 N-(4-(phenylsulfonyl)phenyl)acetamide 
• 1678-25-7 N-phenylbenzenesulfonamide 
• 952-97-6 4-nitrophenyl phenyl sulfide 
• 101094-06-8 ethyl 4-(phenylsulfonyl)benzoate 
• 873-55-2 sodium benzenesulfonate 
• 121-57-3 4-aminobenzene sulfonic acid 
• 71-43-2 benzene 
• 135218-54-1 C₁₂H₁₁NO₂S*C₄₂H₇₀O₃₅ 
• 540-37-4 p-aminoiodobenzene 
• 780-69-8 triethoxyphenylsilane 
• 100-63-0 phenylhydrazine 
• 66003-76-7 Diphenyliodonium triflate 

Downstream Products

• 908306-49-0 4-(4-benzenesulfonylphenylamino)-quinazoline-6-carboxylic acid methoxymethylamide 
• 1439358-24-3 (4-benzenesulfonylphenyl)carbamic acid phenyl ester 
• 1439357-96-6 C₂₀H₁₉N₃O₃S 
• 1439357-98-8 3-[4-(benzenesulfonyl)phenyl]-1-[1-(pyridin-3-yl)ethyl]urea 
• 1439358-00-5 C₂₀H₁₉N₃O₄S 
• 1439358-02-7 C₁₉H₁₆ClN₃O₃S 
• 1363130-82-8 1-[(6-aminopyridin-3-yl)methyl]-3-[4-(benzenesulfonyl)phenyl]urea 
• 1363132-11-9 (1-((6-dimethylamino)pyridin-3-yl)methyl)-3-(4-(phenylsulfonyl)phenyl)urea 
• 1439358-03-8 C₁₉H₁₆FN₃O₃S 
• 1439358-04-9 C₁₈H₁₆N₄O₃S 
• 1439358-05-0 C₁₈H₁₆N₄O₃S 
• 1439358-06-1 C₁₈H₁₆N₄O₃S 
• 1439358-07-2 C₁₈H₁₇N₅O₃S 
• 54528-22-2 1-[4-(benzenesulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea 

Relevant articles and documents

A Copper(I)-Catalyzed Sulfonylative Hiyama Cross-Coupling

An air-tolerant Cu-catalyzed sulfonylative Hiyama cross-coupling reaction enabling the formation of diaryl sulfones is described. Starting from aryl silanes, DABSO and aryliodides, the reaction tolerates a large variety of polar functional groups (amines, ketones, esters, aldehydes). Control experiments coupled with DFT calculations shed light on the mechanism, characterized by the formation of a Cu(I)-sulfinate intermediate via fast insertion of a SO2 molecule.

Method for synthesizing sulfone compounds under photocatalysis condition

The invention belongs to the technical field of compound preparation, and particularly relates to a method for synthesizing sulfone compounds under a photocatalysis condition. Aromatic hydrazine and sulfinate are used as raw materials, and under the action of alkali and a solvent, a sulfone compound is generated through reaction under the condition of air or oxygen under the illumination of visible light. According to the method disclosed by the invention, aryl hydrazine is used as an arylation reagent, polyacid salt is used as a catalyst or an organic photosensitizer is used as a catalyst, and the sulfones compound can be efficiently synthesized by coupling with sulfinate under the condition of room temperature through visible light irradiation. The method has good substrate universalityand relatively mild reaction conditions, is not only a substitute for synthesizing sulfone compounds by coupling from simple substrates reported at present, but also broadens the new application of the polyacid salt in the field of photocatalysis.

Synthesis of Sulfones and Sulfonyl Derivatives using Sodium (tert-butyldimethylsilyl)oxymethanesulfinate

The present invention relates to a method for manufacturing a sulfone and sulfonyl derivative compound using sodium (tert-butyldimethylsilyl)oxymethanesulfinate, which is a novel organic sulfin salt, wherein the novel organic sulfin salt has good stability, environmental friendliness and economy, and is easy to handle, and thus significantly reduces the amount of transition metal catalysts and the amount of organic sulfin salts used when introducing aryl or alkenyl. Also, alkylation, arylation, amination, and fluorination are all possible during secondary functionalization. Therefore, the present invention can be usefully used in preparation and mass production of various kinds of sulfones and derivatives thereof including asymmetric sulfone derivatives.

Silyloxymethanesulfinate as a sulfoxylate equivalent for the modular synthesis of sulfones and sulfonyl derivatives

An efficient protocol for the modular synthesis of sulfones and sulfonyl derivatives has been developed utilizing sodium tert-butyldimethylsilyloxymethanesulfinate (TBSOMS-Na) as a sulfoxylate (SO22-) equivalent. TBSOMS-Na, easily prepared from the commercial reagents Rongalite and TBSCl, serves as a potent nucleophile in S-alkylation and Cu-catalyzed S-arylation reactions with alkyl and aryl electrophiles. The sulfone products thus obtained can undergo the second bond formation at the sulfur center with various electrophiles without a separate unmasking step to afford sulfones and sulfonyl derivatives such as sulfonamides and sulfonyl fluorides.

SUBSTITUTED PHENYL SULFONYL PHENYL TRIAZOLE THIONES AND USES THEREOF

The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.

METHOD OF TREATING A CONDITION ASSOCIATED WITH NEURODEGENERATION USING INHIBITORS OF OAT3

The present disclosure relates to therapeutic agents that may be useful in treatment and prophylaxis of neurodegenerative disorders and/or neural inflammation.

Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase

A high-quality X-ray crystal structure reveals the mechanism of compound 1a inhibiting SIRT2 deacetylase and decanoylase. Structure-activity relationship (SAR) analysis of the synthesized derivatives of 1a reveals the high requirements needed for selectiv

SMALL MOLECULE ACTIVATORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) AND USES THEREOF

Provided herein are small molecule activators of Nicotinamide Phosphoribosyltransferase (NAMPT), compositions comprising the compounds, and methods of using the compounds and compositions.

Visible-Light Photoredox/Nickel Dual Catalysis for the Cross-Coupling of Sulfinic Acid Salts with Aryl Iodides

An efficient cross-coupling of sodium or lithium sulfinates with aryl iodides, using a combination of nickel and photoredox catalysis, is described. The dual catalyst system enables a versatile synthesis of aryl sulfones at room temperature in good yields and displays a broad functional group compatibility. The potential utility of this method in the late-stage diversification of complex molecules and in the conversion of organolithium reagents and sulfur dioxide into sulfones is demonstrated.

METHODS OF INHIBITING BACTERIAL VIRULENCE AND COMPOUNDS RELATING THERETO

The present invention relates to compounds and methods for the treatment of bacterial infections. Because their mechanism of action does not involve killing of bacteria or inhibiting their growth, the potential for these compounds to induce drug resistance in bacteria is minimized. Through inhibiting bacterial virulence, the present invention provides a novel means of treating bacterial infections.