- Photoinduced and Palladium-Catalyzed Remote Desaturation of Amide Derivatives
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A photoinduced and palladium-catalyzed remote desaturation of O-acyl hydroxamides to unsaturated amides under mild conditions has been achieved. The formation of the alkyl Pd(II) intermediate by the recombination of alkyl radical and Pd(I) species is critical to achieve this efficient and selective desaturation of alkanes. This reaction features good site-selectivity, is terminal oxidant-free, and produces moderate to excellent yields for a variety of unsaturated amides. Remarkably, this approach enables late-stage desaturation of complex and biologically important molecules.
- Jin, Weiwei,Yu, Shouyun
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supporting information
p. 6931 - 6935
(2021/09/11)
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- Effects of base, electrophile, and substrate on the selective alkylation of heteroaromatic systems
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Several heteroaromatic systems, including oxazoles, pyrazoles, and thiophenes, are regioselectively alkylated using lithium diethylamide. Effects of substrate, base, and electrophile on the selectivity of this process are surveyed and interpreted.
- Smith, Thomas E.,Mourad, Michelle S.,Velander, Alan J.
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p. 1211 - 1217
(2007/10/03)
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- Phosphorylamides, their preparation and use
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A phosphorylamide derivative represented by the general formula (I): STR1 wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.
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- Regioselective Synthesis of 2-Functionalized Thiophenes by Condensation of α-Mercapto Compounds with β-Aminoenone Derivatives
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2-Acylthiophenes and ethyl 2-thiophenecarboxylates are prepared regioselectively by reaction of 3-chloroenones and 2-acylenammonium chlorides with α-mercapto derivatives in good to moderate yields.
- Alberola, Angel,Andres, Jose M.,Gonzalez, Alfonso,Pedrosa, Rafael,Pradanos, Pedro
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p. 2537 - 2547
(2007/10/02)
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- THE STAGE CHARACTER OF THE OXIDATION OF DIALKYLTHIOPHENES
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The reasons for the stage character of the oxidation of dialkylthiophenes catalyzed by a cobalt bromide catalyst are examined.The stage character of oxidation is due to the deactivation of the catalyst by the corresponding alcohol formed during oxidation.At the first stage of the process only the product from oxidation of the α-alkyl group, i.e., the corresponding ketone, ester, and thiophenecarboxylc acid, are formed.The rate constants for their formation were calculated.
- Volkov, M. N.,Kazakova, O. A.
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p. 370 - 373
(2007/10/02)
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- Dianions of Methylated Thiophene-2-carboxylic Acids: Their Formation and Reactivity
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Methylated thiophene-2-carboxylic acids can be readily homologated by treatment with LDA (2 equiv) followed by the addition of carbon-containing electrophiles.
- Gould, Norman P.,Lee, Ta-Jyh
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p. 4528 - 4530
(2007/10/02)
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