76972-35-5

Basic information

• Product Name: 1-CHLORO-4-(4-METHYLPHENYL)PHTHALAZINE
• Synonyms: 1-Chloro-4-p-tolylphthalazine
• CAS NO: 76972-35-5
• Molecular Formula: C₁₅H₁₁ClN₂
• Molecular Weight: 254.72
• Mol File: 76972-35-5.mol

Chemical Properties

• Melting Point: 159-164℃
• Boiling Point: 450.1 °C at 760 mmHg
• Flash Point: 258.5 °C
• Appearance: /
• Density: 1.251 g/cm³
• CAS DataBase Reference: 1-CHLORO-4-(4-METHYLPHENYL)PHTHALAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-4-(4-METHYLPHENYL)PHTHALAZINE(76972-35-5)
• EPA Substance Registry System: 1-CHLORO-4-(4-METHYLPHENYL)PHTHALAZINE(76972-35-5)

Safety Data

• Hazardous Substances Data: 76972-35-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-CHLORO-4-(4-METHYLPHENYL)PHTHALAZINE is used as a key intermediate in the synthesis of pharmaceuticals for its potential biological and pharmacological properties. It has been studied for its role as an antitumor agent, making it a promising candidate in the development of new cancer treatments.
Used in Agrochemical Industry:
1-CHLORO-4-(4-METHYLPHENYL)PHTHALAZINE is also utilized in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Materials Science:
1-CHLORO-4-(4-METHYLPHENYL)PHTHALAZINE has been investigated for its potential use in materials science, where it may contribute to the creation of novel materials with specific properties for various applications.
Used in Organic Synthesis:
1-CHLORO-4-(4-METHYLPHENYL)PHTHALAZINE serves as a valuable building block in organic synthesis, enabling the development of a wide range of organic compounds for different industries and applications.

Upstream product

• 108-88-3 toluene 
• 1875-48-5 N-aminophthalamide 
• 85-55-2 2-(4-toluoyl)benzoic acid 
• 51334-85-1 4-(4-methylphenyl)-1-(2H)-phthalazinone 

Downstream Products

• 76972-70-8 1-p-Tolyl-4-m-tolylsulfanyl-phthalazine 
• 203728-29-4 4-(4-methylphenyl)phthalazin-1-ylguanidine 
• 307513-15-1 4-para-tolylphthalazine-1(2H)-thione 
• 155936-75-7 1-amino-4-(4-methylphenyl)phthalazine 

Relevant articles and documents

A novel method for heterocyclic amide-thioamide transformations

In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61°C to afford heteocyclic thioamides in excellent yields.

Synthesis of some new phthalazines and their evaluation as corrosion inhibitors of steel

A convenient synthesis has been achieved of 11 substituted phthalazines starting from the condensation of 2-(p-toluoyl)benzoic acid with hydrazine and some of its simple congeners, H2NNHR. Four of the phthalazines showed activity as inhibitors of the corr

New 1,4-disubstituted phthalazines: Synthesis, structure and herbicidal evaluation

The rapid synthesis of eighteen new 1,4-disubstituted phthalazines bearing an aryl or benzyl substituent at C-4 and a variety of aryloxy groups at C-1 is reported; full structural assignments are provided by NMR and MS data together with the biological evaluation for some representative terms of the series.

Condensed pyridazinyl guanidines, their production and use

Pyridazinyl guanidines of the formula: wherein ring A is a benzene ring or a nitrogen-containing 6-membered aromatic ring, each of which may be substituted; and R1is an aromatic ring group which may be substituted, or a salt thereof, which have activity for inhibiting Na-H exchange and are useful as a prophylactic/therapeutic agent for ischemic cardiovascular diseases such as myocardial infarction and arrythmia.

Synthesis and Reactions of Phthalazine Derivatives

Hydrazones (Ia-c) fail to undergo cyclisation under different conditions to yield phthalazines (IIa-c). o-Aroylbenzoic acids (IVa-c) on treatment with hydrazine hydrate give 4-aryl-1(2H)-phthalazinones (Va-c) which react with POCl3 to yield 4-aryl-1-chlor