79386-90-6

Basic information

• Product Name: 1,5-dichloropentan-2-one
• CAS NO: 79386-90-6
• Molecular Formula: C₅H₈Cl₂O
• Molecular Weight: 155.0224
• Mol File: 79386-90-6.mol

Chemical Properties

• Boiling Point: 218.8°C at 760 mmHg
• Flash Point: 87.5°C
• Density: 1.183g/cm³
• Vapor Pressure: 0.124mmHg at 25°C
• Refractive Index: 1.446
• CAS DataBase Reference: 1,5-dichloropentan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-dichloropentan-2-one(79386-90-6)
• EPA Substance Registry System: 1,5-dichloropentan-2-one(79386-90-6)

Safety Data

• Hazardous Substances Data: 79386-90-6(Hazardous Substances Data)

Usage

Physical state

Clear, colorless liquid

Odor

Strong

Usage

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds

Additional use

Solvent in various chemical processes

Safety concerns

Potentially harmful if ingested or inhaled

Precautions

Necessary when handling and storing the compound

Upstream product

• 186581-53-3 diazomethane 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 75-19-4 cyclopropane 
• 79-04-9 chloroacetyl chloride 
• 7446-70-0 aluminium trichloride 
• 67-66-3 chloroform 

Downstream Products

• 851286-21-0 3-(5-chloro-2-oxo-pentylsulfanyl)-4-(5-chloro-2-hydroxy-phenyl)-6-trifluoromethyl-1H-quinolin-2-one 
• 522648-84-6 1-[3-(6-bromobenzo[b]thiophene-3-yl)propyl]-4-(2-methoxyphenyl)piperazine 
• 522648-82-4 1-[3-(4-bromobenzo[b]thiophene-3-yl)propyl]-4-(2-methoxyphenyl)piperazine 
• 1577-22-6 5-hexenoic acid 
• 144121-60-8 1-phenylhex-5-en-1-ol 

Relevant articles and documents

4'-AMINO CYCLIC COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY

The present disclosure provides compounds having affinity for the 5-HT6 receptor which are of the formula (I): formula (I) wherein Cy is selected from formula (Il) and wherein R1, R2, R3, Q, G, Ar, m, n and p are as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Preparation of 1-aminoalkylphosphonic acids and 2-aminoalkylphosphonic acids by reductive amination of oxoalkylphosphonates

By reacting dialkyl 1-oxo- or 2-oxoalkylphosphonates with benzhydrylamine followed by reduction with triacetoxyborohydride and acid hydrolysis gave corresponding aminoalkylphosphonic acids with satisfactory yields. The use of benzylamine, α-methylbenzylamine and tritylamine was unsuccessful in the case of dialkyl 1-oxoalkylphosphonates whereas conversion of 2-oxoalkylphosphonates was also achieved although with lower yields.

Lithium or Bromomagnesium 1,4- and 1,5-Dilithioalkan-2-yloxides: Preparation and Synthetic Applications

Treatment of chloromethyl 2- or 3-chloroalkyl carbinols with butyllithium and then lithium naphthalenide or with ethylmagnesium bromide and then powdered lithium leads to the formation of lithium or bromomagnesium dilithiothioalkoxides, respectively, which represent trianionic species.The bromomagnesium 1,ω-dilithio-2-alkoxides undergo immediate elimination of lithium bromide and magnesium oxide to give ω-lithio-1-alkenes.These latter organometallic compounds as well as the lithium dithioalkoxides react with various electrophiles to afford functionalized compounds.

Benzhydrylpiperozinyl thiazole derivatives and pharmaceutical composition comprising the same

Benzhydrylpiperazinyl Thiazole compounds of the formula STR1 wherein R1 is hydrogen, amino, or mono- or di- substituted amino, in which the substituent is selected from lower alkyl, acyl and di(lower)alkylaminomethylene, R2 is hydrogen, halogen, lower alkyl or aryl, R3 is ar(lower)alkyl optionally substituted by halogen, A is lower alkylene optionally interrupted by a sulfur atom, and Y is C1 -C3 alkylene, having antiallergic activity.