802-93-7Relevant articles and documents
A dendritic macromolecule fluorine - 19 magnetic resonance developer and its preparation method and application (by machine translation)
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Paragraph 0022; 0024-0026, (2017/08/25)
The invention discloses a dendritic macromolecule fluorine - 19 magnetic resonance developer and its preparation method and application. Developer of the present invention is to fluorine-containing dendritic macromolecule as the skeleton, peripheral end group is connected with the functional molecule, its preparation method comprises the following steps: through the Lewis acid under the catalysis of the Friedel-crafts reaction of hexafluoroacetone with benzene will double-trifluoromethyl tertiary alcohol introduction benzene, in fuming sulfuric acid under the action of the iodination reaction, and then introduced into the propynyl structure through the coupling reaction, hydrogenating the resultant fluorine-containing structure unit Q; phosphorus tribromide in Q through the primary conversion of hydroxy group to bromine, then in hydroxy Q with the bromo generating ether linkage synthesis of 1st on behalf of the dendritic macromolecule, repeated brominated and ether generating reaction to obtain 2nd, three generations of dendritic macromolecule, finally through the brominated 3rd on behalf of the branched chain with the ligand through ether bond and to obtain the developer of the present invention. Developer of the present invention can be used for magnetic resonance imaging and the quantitative, visual, transmission and release and the like field. (by machine translation)
PERFLUOROALKYLATION OF BENZENE DERIVATIVES. AN IMPROVED SYNTHESIS OF 1,3-BIS(2-HYDROXYHEXAFLUORO-2-PROPYL)-5-(PERFLUORO-n-ALKYL)BENZENES
Sepiol, Janiusz,Soulen, Robert L.
, p. 61 - 74 (2007/10/02)
A three-step high yield synthesis of various 1,3-bis(2-hydroxyhexafluoro-2-propyl)-5-perfluoro-n-alkyl) benzenes is described.Significant improvements in the iodination and perfluoro-alkylation of a perfluoroalkylbenzene diol have been achieved.Copper coupling of straight-chain perfluoroalkyl iodides with the iodobenzene derivative in DMSO gave the desired compounds as DMSO complexes in 78-91 percent yield.