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1-(phenylsulfonyl)indoline is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 81114-41-2 Structure
  • Basic information

    1. Product Name: 1-(phenylsulfonyl)indoline
    2. Synonyms: 1-(phenylsulfonyl)indoline;1-(phenylsulfonyl)indoline(WXC05796)
    3. CAS NO:81114-41-2
    4. Molecular Formula: C14H13NO2S
    5. Molecular Weight: 259.32352
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 81114-41-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(phenylsulfonyl)indoline(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(phenylsulfonyl)indoline(81114-41-2)
    11. EPA Substance Registry System: 1-(phenylsulfonyl)indoline(81114-41-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 81114-41-2(Hazardous Substances Data)

81114-41-2 Usage

Type of compound

Sulfonylindoline derivative

Usage

Reactant in organic synthesis

Specific application

Preparation of pharmaceutical compounds

Structural feature

Presence of phenylsulfonyl group

Reactivity

Unique reactivity and selectivity in chemical reactions due to phenylsulfonyl group

Field of interest

Medicinal chemistry

Potential

Building block for synthesis of biologically active molecules

Check Digit Verification of cas no

The CAS Registry Mumber 81114-41-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,1,1 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 81114-41:
(7*8)+(6*1)+(5*1)+(4*1)+(3*4)+(2*4)+(1*1)=92
92 % 10 = 2
So 81114-41-2 is a valid CAS Registry Number.

81114-41-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-benzenesulfonyl-2,3-dihydro-1H-indole

1.2 Other means of identification

Product number -
Other names 1-(phenylsulfonyl)indolin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:81114-41-2 SDS

81114-41-2Relevant articles and documents

Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides

Qu, Erdong,Li, Shangzhang,Bai, Jin,Zheng, Yan,Li, Wanfang

supporting information, p. 58 - 63 (2021/12/27)

Herein we report a Ni-catalyzed reductive transamidation of conveniently available N-acyl benzotriazoles with alkyl, alkenyl, and aryl nitro compounds, which afforded various amides with good yields and a broad substrate scope. The same catalytic reaction conditions were also applicable for N-sulfonyl benzotriazoles, which could undergo smooth reductive coupling with nitroarenes and nitroalkanes to afford the corresponding sulfonamides.

Hypervalent Iodine Mediated Sulfonamide Synthesis

Poeira, Diogo L.,Macara, Jo?o,Faustino, Hélio,Coelho, Jaime A. S.,Gois, Pedro M. P.,Marques, M. Manuel B.

supporting information, p. 2695 - 2701 (2019/04/08)

A new metal-free sulfonylation reaction is described. The method takes advantage of the Umpolung reactivity and group-transfer properties of iodine(III) compounds, combining hypervalent iodine reagents and sulfinate salts to deliver a clean and mild transfer of sulfonyl groups to amines and anilines. A total of 25 sulfonamides was synthesised in up to 99 % yield, even on gram-scale. The reaction mechanism was investigated by ESI-MS and DFT calculations.

ORGANIC REACTIONS CARRIED OUT IN AQUEOUS SOLUTION IN THE PRESENCE OF A HYDROXYALKYL(ALKYL)CELLULOSE OR AN ALKYLCELLULOSE

-

Page/Page column 247; 248, (2017/08/21)

The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

-

Paragraph 0451; 1769, (2015/09/22)

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Indolinyl-thiazole based inhibitors of scavenger receptor-BI (SR-BI)-mediated lipid transport

Dockendorff, Chris,Faloon, Patrick W.,Yu, Miao,Youngsaye, Willmen,Penman, Marsha,Nieland, Thomas J. F.,Nag, Partha P.,Lewis, Timothy A.,Pu, Jun,Bennion, Melissa,Negri, Joseph,Paterson, Conor,Lam, Garrett,Dandapani, Sivaraman,Perez, José R.,Munoz, Benito,Palmer, Michelle A.,Schreiber, Stuart L.,Krieger, Monty

supporting information, p. 375 - 380 (2015/04/27)

A potent class of indolinyl-thiazole based inhibitors of cellular lipid uptake mediated by scavenger receptor, class B, type I (SR-BI) was identified via a high-throughput screen of the National Institutes of Health Molecular Libraries Small Molecule Repo

Metal-free direct construction of sulfonamides via iodine- mediated coupling reaction of sodium sulfinates and amines at room temperature

Wei, Wei,Liu, Chunli,Yang, Daoshan,Wen, Jiangwei,You, Jinmao,Wang, Hua

supporting information, p. 987 - 992 (2015/03/30)

A simple, practical, and metal-free protocol has been developed for the synthesis of sulfonamides from sodium sulfinates and various amines through an iodine-mediated SN bond formation reaction at room temperature. This green reaction is cost-effective, operationally straightforward, and especially proceeds under very mild conditions to afford the target products in good to excellent yields (up to 98%).

Discovery of N -(2,4-Di- tert -butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a potent and orally bioavailable CFTR potentiator

Hadida, Sabine,Van Goor, Fredrick,Zhou, Jinglan,Arumugam, Vijayalaksmi,McCartney, Jason,Hazlewood, Anna,Decker, Caroline,Negulescu, Paul,Grootenhuis, Peter D. J.

supporting information, p. 9776 - 9795 (2015/01/16)

Quinolinone-3-carboxamide 1, a novel CFTR potentiator, was discovered using high-throughput screening in NIH-3T3 cells expressing the F508del-CFTR mutation. Extensive medicinal chemistry and iterative structure-activity relationship (SAR) studies to evaluate potency, selectivity, and pharmacokinetic properties resulted in the identification of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, 48, ivacaftor), an investigational drug candidate approved by the FDA for the treatment of CF patients 6 years of age and older carrying the G551D mutation.

THIAZOLE-BASED INHIBITORS OF SCAVENGER RECEPTOR BI

-

Page/Page column 21; 42; 43, (2014/05/07)

This application describes compounds and methods that can inhibit Scavenger receptor class B, type I (SR-BI) activity, which compounds and methods can used, for example, to mediate high-density lipoprotein (HDL) lipid uptake and treat hepatitis C viral in

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

-

, (2012/12/14)

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Sulfonamides for the Modulation of PKM2

-

Page/Page column 54, (2012/05/07)

The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.

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