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84222-50-4

2-amino-7-[(1,3-dihydroxypropan-2-yl)oxy]methyl-3,7-dihydro-6H-purin-6-one, also known as Adenine arabinonucleoside, is a purine nucleoside chemical compound with potential applications in antiviral, anticancer, anti-inflammatory, and immunomodulatory therapies. It has been studied for its ability to inhibit the replication of human immunodeficiency virus (HIV) and other retroviruses, as well as its cytotoxic effects on cancer cells.

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  • 84222-50-4 Structure

  • Basic information

    1. Product Name: 2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-3,7-dihydro-6H-purin-6-one
    2. Synonyms:
    3. CAS NO:84222-50-4
    4. Molecular Formula: C9H13N5O4
    5. Molecular Weight: 255.2306
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 84222-50-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 675°C at 760 mmHg
    3. Flash Point: 362°C
    4. Appearance: N/A
    5. Density: 1.81g/cm3
    6. Vapor Pressure: 3.82E-19mmHg at 25°C
    7. Refractive Index: 1.76
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-3,7-dihydro-6H-purin-6-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-3,7-dihydro-6H-purin-6-one(84222-50-4)
    12. EPA Substance Registry System: 2-amino-7-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-3,7-dihydro-6H-purin-6-one(84222-50-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 84222-50-4(Hazardous Substances Data)

84222-50-4 Usage

Uses

Used in Antiviral Applications:
2-amino-7-[(1,3-dihydroxypropan-2-yl)oxy]methyl-3,7-dihydro-6H-purin-6-one is used as an antiviral agent for inhibiting the replication of human immunodeficiency virus (HIV) and other retroviruses.
Used in Anticancer Applications:
2-amino-7-[(1,3-dihydroxypropan-2-yl)oxy]methyl-3,7-dihydro-6H-purin-6-one is used as an anticancer agent, exhibiting cytotoxic effects on cancer cells and potentially contributing to the development of new therapeutic agents for cancer treatment.
Used in Anti-inflammatory Applications:
2-amino-7-[(1,3-dihydroxypropan-2-yl)oxy]methyl-3,7-dihydro-6H-purin-6-one is used as an anti-inflammatory agent, with its potential to modulate inflammatory responses and contribute to the development of new therapeutic agents for inflammatory conditions.
Used in Immunomodulatory Applications:
2-amino-7-[(1,3-dihydroxypropan-2-yl)oxy]methyl-3,7-dihydro-6H-purin-6-one is used as an immunomodulatory agent, with its potential to modulate immune responses and contribute to the development of new therapeutic agents for immune-related disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 84222-50-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,2,2 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 84222-50:
(7*8)+(6*4)+(5*2)+(4*2)+(3*2)+(2*5)+(1*0)=114
114 % 10 = 4
So 84222-50-4 is a valid CAS Registry Number.

84222-50-4Downstream Products

84222-50-4Relevant articles and documents

A facile synthesis of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (ganciclovir) from guanosine

Boryski, Jerzy,Golankiewicz, Bozenna

, p. 625 - 628 (2007/10/03)

The potent and selective antiviral drug ganciclovir (6) has been synthesized in two steps via transpurination of fully acetylated guanosine (1) in the presence of 1,3-diacetoxy-2-(acetoxymethoxy)propane (2), followed by deacetylation in aqueous ammonia. The transpurination reaction also provides valuable side products, tetra-O-acetyl-β-D-ribofuranose (5) and the 7-regioisomer of triacetylganciclovir (4); the latter product can be converted to the desired 9-isomer in a thermal 7 ? 9 isomerization.

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