84222-48-0

Basic information

• Product Name: N²-acetyl-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine
• Synonyms: N²-acetyl-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine
• CAS NO: 84222-48-0
• Molecular Weight: 477.52
• Mol File: 84222-48-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N²-acetyl-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-acetyl-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine(84222-48-0)
• EPA Substance Registry System: N²-acetyl-7-<<1,3-bis(benzyloxy)-2-propoxy>methyl>guanine(84222-48-0)

Safety Data

• Hazardous Substances Data: 84222-48-0(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 74564-16-2 1,3-dibenzyloxy-2-(chloromethoxy)propane 
• 6972-79-8 dibenzyl glycerol 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 84245-11-4 1-benzyloxy-3-benzyloxy-2acetyloxymethoxypropane 
• 3056-33-5 2,9-diacetylguanine 
• 19962-37-9 N-(6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide 

Downstream Products

• 84222-50-4 7-(1,3-dihydroxy-2-propoxymethyl)guanine 
• 84222-49-1 7-[(1,3-dibenzyloxy-2-propoxy)methyl]guanine 

Relevant articles and documents

A novel approach to the synthesis of the purine anti-viral agent gancyclovir

The aim of this research is to synthesize gancyclovir, a purine anti-viral drug in large scale via simple intermediates. Reaction of guanine 1 with acetic anhydride followed by the attachment of the 2-O-acetoxymethyl-1,3-di-O-benzyl glycerol 3 as a side chain, subsequently lead to the production of N2acetyl-9-(1,3dibenzyloxy-2-propoxymethyl)guanine 6 and N2, acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine 7 and finally synthesizing gancyclovir 8. Among many pathways to the synthesis of purine derivatives, our four step procedure results in good yield and is proved to be an economic way of large scale synthesis.

Biologically active acyclonucleoside analogues. II. The synthesis of 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine (BIOLF-62)

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