849107-20-6

Basic information

• Product Name: 4-(2-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE
• Synonyms: 4-(2-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE;1-Chloro-2-[(piperidine-4-yl)oxy]benzene hydrochloride;4-(2-Chlorophenoxy)piperidiniuM chloride;Piperidine,4-(2-chlorophenoxy)-,hydrochloride;Piperidine, 4-(2-chlorophenoxy)-, hydrochloride (1:1)
• CAS NO: 849107-20-6
• Molecular Formula: C11H15Cl2NO
• Molecular Weight: 248.15
• Mol File: 849107-20-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-(2-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE(849107-20-6)
• EPA Substance Registry System: 4-(2-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE(849107-20-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 849107-20-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Chlorophenoxy)piperidine hydrochloride is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its structure, which includes a piperidine ring and a chlorophenoxy group, makes it a valuable building block for the development of new drugs.
Used in Organic Chemistry Research:
4-(2-Chlorophenoxy)piperidine hydrochloride is used as a research compound in the field of organic chemistry. Its unique molecular structure allows scientists to study its reactivity, properties, and potential applications in the synthesis of other compounds.
Used in Drug Delivery Systems:
4-(2-Chlorophenoxy)piperidine hydrochloride can be used as a component in drug delivery systems. Its hydrochloride salt form may improve the solubility and bioavailability of drugs, facilitating their transport and absorption in the body.
Used in Chemical Synthesis:
4-(2-Chlorophenoxy)piperidine hydrochloride is used as a reagent in chemical synthesis processes. Its presence in a variety of pharmaceuticals and natural products makes it a key component in the production of certain compounds.

Upstream product

• 900512-07-4 1-benzyl-4-(2-chloro-phenoxy)piperidine 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 95-57-8 2-monochlorophenol 
• 552868-10-7 4-(2-chloro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 944240-57-7 C₂₀H₂₂ClN₃O₄ 
• 944240-42-0 C₁₉H₂₁ClN₄O₄ 

Relevant articles and documents

NOVEL ARYLOXYPIPERIDINE PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS

Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

NITROGEN HETEROCYCLE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN HUMAN THERAPEUTICS

The present invention relates to compounds having general formula I characterised in that wherein in particular: R1 represents one or a plurality of groups such as: trifluoromethyl, halogen such as F, Cl, Br, methyl, nitro. R represents nitroge

DERIVATIVES OF 2H PYRIDAZIN- 3 -ONES, THEIR PREPARATION AND THEIR USE AS SCD-1 INHIBITORS

The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular: -R1 represents one or more groups such as: trif luoromethyl, halogen such as F, C1, -when n=m=1, W represents CH then Y represents oxygen, -U represents: ? either - (C=O) CH2NH- and is branched at position 4 of pyridazinone, then R2 represents H, ? or -(C=O)NH- and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H, - R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enyzme inhibitors for the treatment of obesitz, tzpe-2 diabetes and lipid disorders.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors

A series of structurally novel stearoyl-CoA desaturase1 (SCD1) inhibitors has been identified via molecular scaffold manipulation. Preliminary structure-activity relationship (SAR) studies led to the discovery of potent, and orally bioavailable piperidine-aryl urea-based SCD1 inhibitors. 4-(2-Chlorophenoxy)-N-[3-(methyl carbamoyl)phenyl]piperidine-1-carboxamide 4c exhibited robust in vivo activity with dose-dependent desaturation index lowering effects.

Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors

Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids. Studies with SCD1 knockout mice have established that these animals are lean and protected from leptin

Substituted triazole derivatives as oxytocin antagonists

The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction.