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CAS

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851784-80-0

2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1H)-dicarboxylate is a chemical compound with the molecular formula C19H21Cl2NO4. It is a diester derivative of isoquinoline, featuring a tert-butyl group, a methyl group, and two chlorine atoms. 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate possesses potential pharmaceutical applications due to its unique structural properties and possible biological activities.

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  • 2-tert-butyl 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1H)-dicarboxylate

    Cas No: 851784-80-0

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  • 851784-80-0 5,7-dichloro-3,4-dihydro-2,6(1H)-Isoquinolinedicarboxylic acid, 2-(1,1-dimethylethyl) 6-methyl ester

    Cas No: 851784-80-0

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  • 851784-80-0 Structure

  • Basic information

    1. Product Name: 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate
    2. Synonyms: 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate
    3. CAS NO:851784-80-0
    4. Molecular Formula:
    5. Molecular Weight: 360.237
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 851784-80-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate(851784-80-0)
    11. EPA Substance Registry System: 2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1Η)-dicarboxylate(851784-80-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 851784-80-0(Hazardous Substances Data)

851784-80-0 Usage

Uses

Used in Pharmaceutical Industry:
2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1H)-dicarboxylate is used as a potential drug candidate for its potential antiviral, antibacterial, antifungal, and anticancer properties. Its unique structure and biological activities make it a promising compound in the development of new therapeutic agents.
Used in Medicinal Chemistry Research:
2-(tert-butyl) 6-methyl 5,7-dichloro-3,4-dihydroisoquinoline-2,6(1H)-dicarboxylate is utilized in medicinal chemistry research and drug discovery processes. Its structural properties and potential biological activities provide valuable insights for the design and synthesis of novel compounds with therapeutic effects.

Check Digit Verification of cas no

The CAS Registry Mumber 851784-80-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,1,7,8 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 851784-80:
(8*8)+(7*5)+(6*1)+(5*7)+(4*8)+(3*4)+(2*8)+(1*0)=200
200 % 10 = 0
So 851784-80-0 is a valid CAS Registry Number.

851784-80-0Relevant articles and documents

NOVEL PROCESS FOR THE PREPARATION OF LIFITEGRAST

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Page/Page column 17-18, (2019/05/02)

The present invention relates to a novel process for the preparation of lifitegrast of Formula (I). The present invention further provides a novel process for the purification of lifitegrast of Formula (I).

LFA-1 INHIBITOR AND POLYMORPH THEREOF

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, (2014/02/16)

Methods of preparation and purification of a compound, intermediates thereof, a polymorph thereof, and related compounds are disclosed. Formulations and uses thereof in the treatment of LFA -1 mediated diseases are also disclosed.

Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists

Zhong, Min,Shen, Wang,Barr, Kenneth J.,Arbitrario, Jennifer P.,Arkin, Michelle R.,Bui, Minna,Chen, Teresa,Cunningham, Brian C.,Evanchik, Marc J.,Hanan, Emily J.,Hoch, Ute,Huen, Karen,Hyde, Jennifer,Kumer, Jeffery L.,Lac, Teresa,Lawrence, Chris E.,Martell, Jose R.,Oslob, Johan D.,Paulvannan, Kumar,Prabhu, Saileta,Silverman, Jeffrey A.,Wright, Jasmin,Yu, Chul H.,Zhu, Jiang,Flanagan, W. Mike

scheme or table, p. 5269 - 5273 (2010/10/18)

This letter describes the discovery of a novel series of tetrahydroisoquinoline (THIQ)-derived small molecules that potently inhibit both human T-cell migration and super-antigen induced T-cell activation through disruption of the binding of integrin LFA-1 to its receptor, ICAM-1. In addition to excellent in vitro potency, 6q shows good pharmacokinetic properties and its ethyl ester (6t) demonstrates good oral bioavailability in both mouse and rat. Either intravenous administration of 6q or oral administration of its ethyl ester (6t) produced a significant reduction of neutrophil migration in a thioglycollate-induced murine peritonitis model.

MODULATORS OF CELLULAR ADHESION

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Page/Page column 76-78, (2010/02/11)

The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).

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