851784-82-2Relevant articles and documents
INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF
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Paragraph 0724; 1140-1142, (2021/11/06)
Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same.
A method for synthesizing intermediate advantage non-si te (by machine translation)
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Paragraph 0073-0074, (2018/04/21)
The invention discloses a method of preparing intermediates of advantage non-si te, comprises the following steps: (1) heating compound 1, tetramethyl diethylamine and butyl lithium treatment, adding chloromethane acid benzyl ester, in - 70 °C following temperature reaction, to obtain compound 2; (2) taking compound 2 with the strong alkali solution reaction, after the reaction adjusting PH to 3 - 4, extraction, to obtain compound 3. The advantage non-si te intermediates prepared by the process of a high degree of selectivity, the controllability is strong, good stability, the total yield is high, suitable for commercial scale production. (by machine translation)
Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists
Zhong, Min,Shen, Wang,Barr, Kenneth J.,Arbitrario, Jennifer P.,Arkin, Michelle R.,Bui, Minna,Chen, Teresa,Cunningham, Brian C.,Evanchik, Marc J.,Hanan, Emily J.,Hoch, Ute,Huen, Karen,Hyde, Jennifer,Kumer, Jeffery L.,Lac, Teresa,Lawrence, Chris E.,Martell, Jose R.,Oslob, Johan D.,Paulvannan, Kumar,Prabhu, Saileta,Silverman, Jeffrey A.,Wright, Jasmin,Yu, Chul H.,Zhu, Jiang,Flanagan, W. Mike
scheme or table, p. 5269 - 5273 (2010/10/18)
This letter describes the discovery of a novel series of tetrahydroisoquinoline (THIQ)-derived small molecules that potently inhibit both human T-cell migration and super-antigen induced T-cell activation through disruption of the binding of integrin LFA-1 to its receptor, ICAM-1. In addition to excellent in vitro potency, 6q shows good pharmacokinetic properties and its ethyl ester (6t) demonstrates good oral bioavailability in both mouse and rat. Either intravenous administration of 6q or oral administration of its ethyl ester (6t) produced a significant reduction of neutrophil migration in a thioglycollate-induced murine peritonitis model.