- Preparation and application of 2-pyridine carboxamide compound
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The invention relates to a 2-pyridine carboxamide derivative as shown in a formula I, and pharmaceutically acceptable salt, hydrate, solvate and prodrug thereof. Substituents R1, R2, X and Y have themeanings given in the description. The invention further relates to a compound in the general formula I, and the compound has the strong inhibition effect on FLT-3; the invention further relates to the applications of the compound, and the pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof to preparation of drugs for treating diseases caused by abnormal high expression of FLT-3kinase, especially the applications to preparation of drugs for treating and/or preventing cancers.
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Paragraph 0099; 0111-0112
(2019/12/25)
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- The preparation method of the zola non-nepal (by machine translation)
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The invention discloses a method for preparing zola non-nepal, the states the zola non-nepal the chemical name is 4 - {4 - [( {4 - chloro - 3 - (trifluoromethyl) phenyl] amino} carbonyl) amino] phenoxy} - N - methylpyridine - 2 - carboxamide; the process of the invention has simple process, raw materials are easy, economic and environmental protection, help to realize industrialization, can promote the zola non-nepal drug of economic and technological development, and reduces the production cost, high yield, low environmental pollution, is suitable for mass production. (by machine translation)
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- A method for synthesizing intermediate zola non-nepal
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The invention discloses a synthesis method for a sorafenib intermediate. The synthesis method comprises the following steps: using N-methyl(4-chlorine-2pyridyl)formamide and p-nitrophenol as raw materials, and conducting etherification reaction and hydrogenation reduction to obtain 4-(4-aminophenoxy)-N-methyl-2-pyridinecarboxamide (a compound 1). The yield of 4-(4-aminophenoxy)-N-methyl-2-pyridinecarboxamide obtained according to the synthesis method is 80% or above, the yield of the sorafenib intermediate is 90% or above, and the synthesis process is simple and easy to control, and suitable for large-scale industrialized production.
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Paragraph 0028; 0031; 0032; 0035; 0038; 0041; 0044; 0047
(2018/07/30)
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- Preparation method of Sorafenib tosylate related intermediate
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The invention discloses a preparation method of a Sorafenib tosylate related intermediate, and belongs to the technical field of medicines. -CONHCH3 is generated by -COOH, halogen atoms are connectedonto a pyridine ring at normal temperature to synthesize a compound 3, and energy consumption is reduced. Moreover, post-treatment is simple, operation is easy, the purity of a treated product at eachstep can reach 95%, the product can be directly used for a next step, and the preparation method is suitable for industrial production.
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Paragraph 0041; 0042
(2018/09/11)
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- SEMICARBAZIDE DERIVATIVES AS KINASE INHIBITORS
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The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.
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Page/Page column 209
(2008/06/13)
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