86900-39-2

Basic information

• Product Name: (R,S)-N-Ethylnornicotine
• Synonyms: (±)-3-(1-Ethyl-2-pyrrolidinyl)pyridine;3-(1-Ethyl-2-pyrrolidinyl)pyridine
• CAS NO: 86900-39-2
• Molecular Formula: C11H16N2
• Molecular Weight: 176.25814
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Mutagenesis Research Chemicals;Nicotine Derivatives
• Mol File: 86900-39-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• CAS DataBase Reference: (R,S)-N-Ethylnornicotine(CAS DataBase Reference)
• NIST Chemistry Reference: (R,S)-N-Ethylnornicotine(86900-39-2)
• EPA Substance Registry System: (R,S)-N-Ethylnornicotine(86900-39-2)

Safety Data

• Hazardous Substances Data: 86900-39-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(R,S)-N-Ethylnornicotine is used as a research chemical for studying its vasoconstrictor properties and potential applications in the development of medications targeting blood vessel constriction.
Used in Chemical Research:
As a derivative of nicotine, (R,S)-N-Ethylnicotine is utilized in chemical research to understand its structure, properties, and potential interactions with biological systems, which can contribute to the advancement of knowledge in the field of chemistry and pharmacology.

Upstream product

• 3000-78-0 N'-acetylnornicotine 
• 75-04-7 ethylamine 
• 76014-80-7 4-Oxo-1-(3-pyridyl)-1-butanone 
• 59-67-6 nicotinic acid 
• 95091-91-1 N-methoxy-N-methylpyridine-3-carboxamide 
• 421557-52-0 3-(4,4-dimethoxy-1-oxobutyl)pyridine 
• 5746-86-1 rac-nornicotine 

Downstream Products

• 5979-92-0 N'-ethyl-S-nornicotine 

Relevant articles and documents

N'-ETHYLNORNICOTINE FROM BURLEY TOBACCO

A new alkaloid N'-ethylnornicotine was isolated from the leaf of Burley tobacco (Nicotiana tabacum) and the structure was confirmed by chemical synthesis.

Racemization method and application of pyridine derivative

The invention belongs to the field of medicines, and particularly relates to a racemization method and application of a pyridine derivative. The method comprises the following steps: carrying out a racemization reaction on the pyridine derivative shown in the following formula I under the action of alkali and a phase transfer catalyst, and carrying out post-treatment to obtain a pyridine derivative racemate, wherein the formula I is shown in the specification. In the formula I, n is selected from -3, -2, -1, 0, 1, 2 and 3, and R represents hydrogen or a C1-C7 carbon-containing group. The alkali is at least one selected from potassium hydroxide, sodium hydroxide and alkali metal alkoxide. The phase transfer catalyst is selected from 18-crown 6-ether, 18-crown 6-ether derivatives, 15-crown 5-ether and 15-crown 5-ether derivatives. A reaction temperature is 20 DEG C to 200 DEG C. The racemization method of the pyridine derivative provided by the invention has the advantages of mild conditions, high racemization speed, few side reactions, high yield, low cost and high practical value, and is suitable for large-scale industrial production and application.

Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers

The sequential use of solid-supported reagents and scavengers has led to an efficient synthesis of the natural products nornicotine 1, nicotine 2 and further fuctionalised derivatives. Also reported is a diastereoselective route to both enantiomers of nicotine 2.