86900-39-2Relevant articles and documents
N'-ETHYLNORNICOTINE FROM BURLEY TOBACCO
Braumann, Thomas,Nicolaus, Gerd,Hahn, Wolfgang,Elmenhorst, Hinrich
, p. 3693 - 3694 (1990)
A new alkaloid N'-ethylnornicotine was isolated from the leaf of Burley tobacco (Nicotiana tabacum) and the structure was confirmed by chemical synthesis.
Racemization method and application of pyridine derivative
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Paragraph 0029-0030, (2021/01/12)
The invention belongs to the field of medicines, and particularly relates to a racemization method and application of a pyridine derivative. The method comprises the following steps: carrying out a racemization reaction on the pyridine derivative shown in the following formula I under the action of alkali and a phase transfer catalyst, and carrying out post-treatment to obtain a pyridine derivative racemate, wherein the formula I is shown in the specification. In the formula I, n is selected from -3, -2, -1, 0, 1, 2 and 3, and R represents hydrogen or a C1-C7 carbon-containing group. The alkali is at least one selected from potassium hydroxide, sodium hydroxide and alkali metal alkoxide. The phase transfer catalyst is selected from 18-crown 6-ether, 18-crown 6-ether derivatives, 15-crown 5-ether and 15-crown 5-ether derivatives. A reaction temperature is 20 DEG C to 200 DEG C. The racemization method of the pyridine derivative provided by the invention has the advantages of mild conditions, high racemization speed, few side reactions, high yield, low cost and high practical value, and is suitable for large-scale industrial production and application.
Synthesis of nornicotine, nicotine and other functionalised derivatives using solid-supported reagents and scavengers
Baxendale, Ian R.,Brusotti, Gloria,Matsuoka, Masato,Ley, Steven V.
, p. 143 - 154 (2007/10/03)
The sequential use of solid-supported reagents and scavengers has led to an efficient synthesis of the natural products nornicotine 1, nicotine 2 and further fuctionalised derivatives. Also reported is a diastereoselective route to both enantiomers of nicotine 2.