874-63-5

Basic information

• Product Name: 3,5-Dimethylanisole
• Synonyms: 1,3-DIMETHYL-5-METHOXYBENZENE;3,5-DIMETHYLANISOLE;5-METHOXY-M-XYLENE;SPECS AC-509/25002099;1-Methoxy-3,5-dimethylbenzene;Anisole, 3,5-dimethyl;Benzene, 1-methoxy-3,5-dimethyl-;3,5-DIMETHYLANISOLE, 99+%
• CAS NO: 874-63-5
• Molecular Formula: C₉H₁₂O
• Molecular Weight: 136.19
• EINECS: 212-865-3
• Product Categories: Aromatic Ethers;Anisoles, Alkyloxy Compounds & Phenylacetates;Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 874-63-5.mol

Chemical Properties

• Boiling Point: 193 °C(lit.)
• Flash Point: 150 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 0.963 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.616mmHg at 25°C
• Refractive Index: n20/D 1.512(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 2040905
• CAS DataBase Reference: 3,5-Dimethylanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dimethylanisole(874-63-5)
• EPA Substance Registry System: 3,5-Dimethylanisole(874-63-5)

Safety Data

• Safety Statements: 24/25
• RIDADR: 3271
• WGK Germany: 3
• Hazardous Substances Data: 874-63-5(Hazardous Substances Data)

Usage

Chemical Properties

clear colourless to light yellow liquid

InChI:InChI=1/C9H12O/c1-7-4-8(2)6-9(5-7)10-3/h4-6H,1-3H3

Upstream product

• 4727-41-7 dimethylsulfonioacetate 
• 108-68-9 3,5-Dimethylphenol 
• 67-56-1 methanol 
• 1123-09-7 3,5-dimethyl-2-cyclohexen-1-one 
• 60999-76-0 1-(4-methoxy-2,6-dimethylphenyl)ethanone 
• 60-29-7 diethyl ether 
• 29578-83-4 3-bromo-5-methoxytoluene 
• 74-88-4 methyl iodide 
• 6981-15-3 4-chloro-3,5-dimethylanisole 
• 108-67-8 1,3,5-trimethyl-benzene 
• 2320-30-1 3,5-dimethylcyclohexanone 
• 77-78-1 dimethyl sulfate 
• 512-56-1 trimethyl phosphite 
• 6267-34-1 2-bromo-5-methoxy-1,3-dimethyl-benzene 

Downstream Products

• 85785-30-4 (4-methoxy-2,6-dimethyl-phenyl)-(4-nitro-phenyl)-diazene 
• 1123-09-7 3,5-dimethyl-2-cyclohexen-1-one 
• 527-54-8 3,4,5-trimethylphenol 
• 6267-34-1 2-bromo-5-methoxy-1,3-dimethyl-benzene 
• 117934-79-9 2,4-diiodo-1-methoxy-3,5-dimethylbenzene 
• 24586-86-5 bis-(4-methoxy-2,6-dimethyl-phenyl)-sulfoxide 
• 860734-33-4 3,5-dimethyl-2,4,6-trinitro-anisole 
• 857590-05-7 3,5-dimethyl-2,4-dinitro-anisole 
• 46331-50-4 5-methoxyisophthalic acid 
• 92516-42-2 2,4,6-tribromo-3,5-dimethylmethoxybenzene 
• 21009-91-6 1-(2-hydroxy-4,6-dimethyl-phenyl)-2-methyl-propan-1-one 
• 19111-77-4 2,6-dimethyl-4-methoxybenzonitrile 
• 75813-41-1 N^α-benzyloxycarbonyl-N^G-(4-methoxy-2,6-dimethylbenzenesulphonyl)arginine 
• 114468-40-5 (E,E)-1-Methoxy-3,5-bis<2-(3,4,5-trimethoxyphenyl)ethenyl>benzol 

Relevant articles and documents

A Mild Heteroatom (O -, N -, and S -) Methylation Protocol Using Trimethyl Phosphate (TMP)-Ca(OH) 2Combination

A mild heteroatom methylation protocol using trimethyl phosphate (TMP)-Ca(OH)2combination has been developed, which proceeds in DMF, or water, or under neat conditions, at 80 °C or at room temperature. A series of O-, N-, and S-nucleophiles, including phenols, sulfonamides, N-heterocycles, such as 9H-carbazole, indole derivatives, and 1,8-naphthalimide, and aryl/alkyl thiols, are suitable substrates for this protocol. The high efficiency, operational simplicity, scalability, cost-efficiency, and environmentally friendly nature of this protocol make it an attractive alternative to the conventional base-promoted heteroatom methylation procedures.

Conversion of Cyclohexanones to Alkyl Aryl Ethers by Using a Pd/C–Ethylene System

The conversion of cyclohexanone and substituted cyclohexanones into alkyl aryl ethers by using a Pd/C–ethylene system is discussed, with ethylene functioning as a hydrogen acceptor. The ether products are easily transformed into the corresponding phenols by treatment with BBr3. The direct conversion of cyclohexenone into phenol in the presence of a catalytic amount of Pd/C under an ethylene atmosphere is also described.

A Divergent Approach to the Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from Atropisomeric N-Aryl Oxindole Derivatives

3,3-Disubstituted oxindoles were divergently synthesized by diastereoselective transformations including nucleophilic addition, alkylation, and cycloaddition using common, axially chiral N-aryl oxindoles. Notably, high diastereoselectivities (up to >95:5) were observed with ortho-monosubstituted N-aryl oxindoles to give various oxindole scaffolds, and facile removal of the p-(benzyloxy)aryl moiety in axially twisted amides was achieved by a mild, two-step sequence.

DEUTERATED BENZOPYRAN COMPOUND AND APPLICATION THEREOF

features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.

Deuterated Benzopyran Compounds and Application Thereof

The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors.

Methylation of phenol and its derivatives with dimethyl carbonate in the presence of Mn2(CO)10, W(CO)6, and Co2(CO)8

Aryl methyl ethers were synthesized by reactions of phenol, substituted phenols, and α- and β-naphthols with dimethyl carbonate in the presence of manganese, tungsten, and cobalt carbonyls. Optimal reactant and catalyst ratios and reaction conditions were found to ensure selective formation of aryl methyl ethers.

A highly active and selective palladium pincer catalyst for the formation of α-aryl ketones via cross-coupling

Several air and moisture stable Pd(ii) pincer complexes were synthesized via oxidative addition of Pd(0) to novel PheBox pincer ligand precursors. Low loadings (1 mol%) of the Pd complex [t-BuPhebox-Me2]PdBr are capable of efficiently promoting the selective α-monoarylation of a variety of ketones with numerous aryl bromides in only 1 h at 70°C with 82-99% yields.

Structure-activity relationship analysis of Pd-PEPPSI complexes in cross-couplings: A close inspection of the catalytic cycle and the precatalyst activation model

A series of Pd-N-heterocyclic carbene (Pd-NHC) complexes with various NHC, halide and pyridine ligands (PEPPSI (pyridine, enhanced, precatalyst, preparation, stabilisation and initiation) precatalysts) were prepared, and the effects of these ligands on catalyst activation and performance were studied in the Kumada-TamaoCorriu (KTC), Negishi, and Suzuki-Miyaura cross-coupling reactions. The lowered reactivity of more hindered 2,6-dimethylpyridyl complex 4 in the Negishi and KTC reactions is consistent with slow reductive dimerisation of the organometallic reaction partner during precatalyst activation. Comparative rate studies of complexes 1, 4 and 5 in the KTC and Suzuki-Miyaura reactions verify that 4 activated more slowly than the others. A potential on/ off mechanism of pyridine coordination to NHC-Pd0 is also plausible, in which the more basic pyridine stays bound for longer.

Eco-friendly hydrodehalogenation of electron-rich aryl chlorides and fluorides by photochemical reaction

Aryl chlorides and fluorides are smoothly hydrodehalogenated by irradiation either in neat i-PrOH or in a polar solution in the presence of hypophosphorous acid or triethylsilane. The procedure gives the halogen-free products in good to excellent yields under mild eco-friendly conditions and avoids the recourse to toxic metal catalysts.

SUBSTITUTED OXAZOLIDINONES

The present invention relates to new oxazolidinone modulators of skeletal muscle function and tone, pharmaceutical compositions thereof, and methods of use thereof.