75813-41-1

Upstream product

• 1234-35-1 Z-Arg-OH 
• 55661-08-0 4-methoxy-2,6-dimethylbenzenesulfonyl chloride 
• 874-63-5 3,5-dimethylmethoxybenzene 

Downstream Products

• 75806-97-2 N^G-Mds-Arg 
• 80760-69-6 Boc-Arg(Mds)-Pro-Lys(Boc)-Pro-OH 
• 80760-65-2 C₂₂H₃₆N₆O₅S 
• 75806-98-3 Boc-Arg(Mds)-OH 
• 74-79-3 L-arginine 
• 80760-64-1 C₃₀H₄₂N₆O₇S 

Relevant academic research and scientific papers

Reinvestigation of the 4-Methoxy-2,6-dimethylbenzenesulphonyl (Mds) Protecting Group for the Guanidino-function during Peptide Synthesis

The procedure for the synthesis of Z-Arg(Mds)-OH yields, in addition to the title compound, three products that have analogues of the Mds group on the guanidino-function making characterization of protected intermediate peptides difficult.

4-Methoxy-2,6-dimethylbenzenesulphonyl (Mds): a New Protecting Group of the Guanidino Function in Peptide Synthesis

The 4-methoxy-2,6-dimethylbenzenesulphonyl (Mds) group for the protection of the guanidino function, which is readily removed with trifluoroacetic acid-thioanisole but is resistant to hydrogenolysis or treatment with dilute hydrogen chloride, can be used in the solution synthesis of arginine-containing peptides; this protecting group was effectively used in the synthesis of substance P and two LH-RH analogues.