884494-84-2

Basic information

• Product Name: 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER
• Synonyms: 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER;3-PYRIDINECARBOXYLIC ACID, 2-FLUORO-4-IODO-,METHYL ESTER;2-Fluoro-4-iodo-3-pyridinecarboxylic acid methyl ester;Methyl 2-Fluoro-4-iodonicotinate;Methyl 2-fluoro-4-iodopyridine-3-carboxylate;Methyl 2-fluoro-4-iodopyridine-3-carboxylate, 2-Fluoro-4-iodo-3-(methoxycarbonyl)pyridine;Methyl 2-Fluoro-4-iodopyridin-3-ylcarbanate
• CAS NO: 884494-84-2
• Molecular Formula: C₇H₅FINO₂
• Molecular Weight: 281.02
• Product Categories: Heterocyclic Compounds;Boronic Acid
• Mol File: 884494-84-2.mol

Chemical Properties

• Boiling Point: 287℃
• Flash Point: 127℃
• Appearance: /
• Density: 1.913
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -3.86±0.18(Predicted)
• CAS DataBase Reference: 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER(884494-84-2)
• EPA Substance Registry System: 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER(884494-84-2)

Safety Data

• Hazardous Substances Data: 884494-84-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Compounds Synthesis:
2-Fluoro-4-iodonicotinic acid methyl ester is used as a building block for the synthesis of pharmaceutical compounds due to its potential biological activity and versatility in chemical reactions. It contributes to the development of new drugs by providing a structural foundation that can be further modified to achieve desired therapeutic effects.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-Fluoro-4-iodonicotinic acid methyl ester is employed as a research tool to explore its interactions with biological targets and understand its potential applications in drug discovery. Its unique properties allow researchers to investigate its effects on various biological pathways and mechanisms, contributing to the advancement of pharmaceutical science.
Used in Organic Molecule Synthesis:
2-Fluoro-4-iodonicotinic acid methyl ester is also used in the synthesis of other organic molecules, where its specific functional groups and structural features can be leveraged to create a diverse range of compounds. This application extends its utility beyond the pharmaceutical industry, making it a valuable component in the broader field of organic chemistry.
Used in Drug Development:
In the process of drug development, 2-Fluoro-4-iodonicotinic acid methyl ester serves as a key intermediate in the synthesis of new drug candidates. Its incorporation into drug molecules can enhance their pharmacological properties, such as potency, selectivity, and bioavailability, ultimately leading to more effective treatments for various diseases and conditions.

InChI:InChI=1/C7H5FINO2/c1-12-7(11)5-4(9)2-3-10-6(5)8/h2-3H,1H3

Upstream product

• 22282-70-8 2-fluoro-4-iodopyridine 
• 67-56-1 methanol 
• 884494-51-3 2-fluoro-4-iodonicotinic acid 
• 153034-82-3 [(fluoro-2-iodo-4)pyrid-3-yl]-carboxaldehyde 
• 372-48-5 2-fluoropyridine 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 1003933-78-5 tert-butyl ({3'-[8-(benzyloxy)-5-hydroxy-7-oxo-7,8-dihydro-1,8-naphthyridin-4-yl]biphenyl-3-yl}methyl)carbamate 
• 1003933-74-1 ethyl 1-(benzyloxy)-5-(3-bromophenyl)-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate 
• 1003933-70-7 methyl 2-[(benzyloxy)(3-ethoxy-3-oxopropanoyl)amino]-4-(3-bromophenyl)nicotinate 
• 1003933-66-1 methyl 2-[(benzyloxy)amino]-4-(3-bromophenyl)nicotinate 

Relevant articles and documents

NOVEL ISOINDOLINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

Disclosed are a novel isoindoline derivative, a pharmaceutical composition and use thereof. The compound of formula I, or the pharmaceutically acceptable salt, solvate, polymorph, co-crystal, stereoisomer, isotopic compound, metabolite or prodrug thereof disclosed in the invention can regulate the generation and/or activity of PDE4 and/or TNF-α so as to effectively treat cancer and inflammatory diseases.

PYRROLIDINE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to pyrrolidine compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for Alzheimer's disease, schizophrenia, pain, sleep disorder and the like. The present invention relates to a compound represented by the formula wherein ring A is a 4- to 7-membered ring optionally having substituent (s) ; L is -O-, -S-, -SO- or -SO2-; R1 is a C1-6 alkyl group optionally having substituent(s) (provided that when L is -O-, R1 is not a C1-6 alkyl group optionally substituted by halogen atom(s)), or a cyclic group optionally having substituent(s); X1 is -CRa= or -N=; X2 is -CRb= or -N=; X3 is-CRc= or -N=; Ra, Rb and Rc are each a C1-6 alkyl group, C2-6 alkenyl group, C1-6 alkoxy group, C3-6 cycloalkyl group, C3-6 cycloalkoxy group or C6-14 aryl group, each of which optionally having substituent(s), H or halogen, or a salt thereof.