88562-26-9

Basic information

• Product Name: 2-BROMOBENZOYL CYANIDE
• Synonyms: 2-BROMOBENZOYL CYANIDE;2-(2-bromophenyl)-2-oxoacetonitrile;(2-BroMo-phenyl)-oxo-acetonitrile
• CAS NO: 88562-26-9
• Molecular Formula: C₈H₄BrNO
• Molecular Weight: 210.03
• Mol File: 88562-26-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BROMOBENZOYL CYANIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOBENZOYL CYANIDE(88562-26-9)
• EPA Substance Registry System: 2-BROMOBENZOYL CYANIDE(88562-26-9)

Safety Data

• Hazardous Substances Data: 88562-26-9(Hazardous Substances Data)

Upstream product

• 866995-73-5 bromo-(2-bromo-phenyl)-nitro-acetic acid amide 
• 506-64-9 silver(I) cyanide 
• 7154-66-7 2-bromobenzoic acid chloride 
• 52923-21-4 2-(2-bromophenyl)-2-hydroxyacetonitrile 
• 6630-33-7 ortho-bromobenzaldehyde 
• 88-65-3 2-bromobenzoic-acid 

Downstream Products

• 50625-52-0 2-bromo-N'-phenylbenzohydrazide 
• 196953-04-5 1-(2-bromophenyl)-buta-2,3-dien-1-one 
• 53882-80-7 3-(2-bromophenyl)-3-oxopropanenitrile 
• 57279-20-6 1-(2-bromophenyl)-butane-1,3-dione 
• 51417-57-3 1,2-Bis(2-bromophenyl)ethane-1,2-dione 
• 122394-38-1 (2-bromophenyl)-oxoacetic acid methyl ester 
• 50890-83-0 1-methyl-1H-indazole-3-carboxylic acid 

Relevant articles and documents

INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 9X

The disclosure provides novel chemical compounds useful as inhibitors of ubiquitin specific peptidase 9X (USP9X). USP9X inhibiting compounds are useful in the treatment of disease and disorders associated with modulation of USP9X, such as cancer.

Acceptorless and Base-free Dehydrogenation of Cyanohydrin with (η6-Arene)halide(Bidentate Phosphine)ruthenium(II) Complex

Ruthenium-catalyzed dehydrogenation of cyanohydrins under acceptorless and base-free conditions was demonstrated for the first time in the synthesis of acyl cyanide. As opposed to the thermodynamically preferred elimination of hydrogen cyanide, the dehydrogenation of cyanohydrins could be kinetically controlled with ruthenium (II) bidentate phosphine complexes. The effects of the arene, phosphine ligands and counter anions were investigated in regard to catalytic activity and selectivity. Selective dehydrogenation can occur via β-hydride elimination with the experimentally observed [(alkoxide)Ru] complex. (Figure presented.).

Regioselective synthesis of 1-substituted indazole-3-carboxylic acids

In this article, we study the synthesis of 1-substituted indazole-3-carboxylic acids from 2-halobenzoic acids.

Chemical process

According to the present invention there is provided process for preparing a compound of formula (I): STR1 or a salt, acylate or sulphonate derivative thereof; wherein R1 is an optionally substituted aryl group, R2, R3, R4 and R5 are selected from hydrogen, C1-4 alkyl, C1-4 alkanoyl or --CO2 Ra wherein Ra is C1-4 alkyl or R2 and R3 or R4 and R5 together with the carbon atom to which they are attached form a C3-6 cycloalkyl ring, provided that at least R2 and R3 or R4 and R5 are not both hydrogen and that not more than two of R2, R3, R4 and R5 are C1-4 alkanoyl or --CO2 Ra ; which process comprises reacting a compound of formula (II): STR2 wherein R2, R3, R4 and R5 are as defined in relation to formula (I) with a compound of formula (III): wherein R1 is as defined in relation to formula (I) in the presence of a base and a Lewis acid.