122394-38-1

Basic information

• Product Name: Methyl 2-(2-broMophenyl)-2-oxoacetate
• Synonyms: Methyl 2-(2-broMophenyl)-2-oxoacetate
• CAS NO: 122394-38-1
• Molecular Formula: C₉H₇BrO₃
• Molecular Weight: 243.05408
• Mol File: 122394-38-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 310.9±25.0 °C(Predicted)
• Appearance: /
• Density: 1.546±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 2-(2-broMophenyl)-2-oxoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(2-broMophenyl)-2-oxoacetate(122394-38-1)
• EPA Substance Registry System: Methyl 2-(2-broMophenyl)-2-oxoacetate(122394-38-1)

Safety Data

• Hazardous Substances Data: 122394-38-1(Hazardous Substances Data)

Usage

General Description

Methyl 2-(2-bromophenyl)-2-oxoacetate is an organic compound with the chemical formula C9H9BrO3. It is a ester derivative of 2-oxoacetic acid and contains a bromine atom attached to a phenyl ring. Methyl 2-(2-broMophenyl)-2-oxoacetate is commonly used in organic synthesis as a reagent and intermediate for the preparation of various compounds. It is known for its potential applications in the pharmaceutical and agrochemical industries. The structure and properties of Methyl 2-(2-bromophenyl)-2-oxoacetate make it a versatile building block for the synthesis of a wide range of organic compounds.

Upstream product

• 264882-02-2 2-bromophenyldiazoacetic acid methyl ester 
• 2142-69-0 2-bromophenyl methyl ketone 
• 74-88-4 methyl iodide 
• 52923-21-4 2-(2-bromophenyl)-2-hydroxyacetonitrile 
• 88562-26-9 2-bromobenzoyl cyanide 
• 88-65-3 2-bromobenzoic-acid 
• 67-56-1 methanol 
• 6630-33-7 ortho-bromobenzaldehyde 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 21165-13-9 methyl 2-(2-bromophenyl)-2-hydroxyacetate 
• 43063-97-4 methyl 2-bromo-2-(2-bromophenyl) acetate 
• 18698-97-0 ortho-bromophenylacetic acid 
• 1218951-02-0 methyl [2-(2-bromophenyl)-2-cyano]acetate 

Downstream Products

• 50890-83-0 1-methyl-1H-indazole-3-carboxylic acid 
• 158036-22-7 2-Ethynylphenylglyoxylic acid methyl ester-O-methyloxime 
• 122283-38-9 (E)-2-(2-Bromo-phenyl)-3-methoxy-acrylic acid methyl ester 

Relevant articles and documents

An efficient synthesis of aryl α-keto esters

A new one-pot approach for the synthesis of aryl α-keto ester based on the diazo transfer and oxidation of diazo group is developed.

Carbene-Catalyzed Enantioselective Aromatic N-Nucleophilic Addition of Heteroarenes to Ketones

The aromatic nitrogen atoms of heteroarylaldehydes are activated by carbene catalysts to react with ketone electrophiles. Multi-functionalized cyclic N,O-acetal products are afforded in good to excellent yields and optical purities. Our reaction involves the formation of an unprecedented aza-fulvene-type acylazolium intermediate. A broad range of N-heteroaromatic aldehydes and electron-deficient ketone substrates works effectively in this transformation. Several of the chiral N,O-acetal products afforded through this protocol exhibit excellent antibacterial activities against Ralstonia solanacearum (Rs) and are valuable in the development of novel agrichemicals for plant protection.

Enantioselective Iridium-Catalyzed Hydrogenation of α-Keto Amides to α-Hydroxy Amides

A highly enantioselective iridium-catalyzed hydrogenation of α-keto amides to form α-hydroxy amides has been achieved with excellent results (up to >99% conversion and up to >99% ee, TON up to 100?000). As an example, this protocol was applied to the synthesis of (S)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol, the enantiomer of norepinephrine, which is widely used as an injectable drug for the treatment of critically low blood pressure. Density functional theory (DFT) calculations were also carried out to reveal the reaction mechanism.