886361-46-2

Basic information

• Product Name: 1-(5-(4-Fluorophenyl)thiophen-2-yl)ethanone
• Synonyms: 1-(5-(4-Fluorophenyl)thiophen-2-yl)ethanone
• CAS NO: 886361-46-2
• Molecular Formula: C₁₂H₉FOS
• Molecular Weight: 220.2626632
• Mol File: 886361-46-2.mol

Chemical Properties

• Melting Point: 119～120℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(5-(4-Fluorophenyl)thiophen-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-(4-Fluorophenyl)thiophen-2-yl)ethanone(886361-46-2)
• EPA Substance Registry System: 1-(5-(4-Fluorophenyl)thiophen-2-yl)ethanone(886361-46-2)

Safety Data

• Hazardous Substances Data: 886361-46-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(5-(4-Fluorophenyl)thiophen-2-yl)ethanone is used as an intermediate in the synthesis of pharmaceuticals for its potential biological activities and unique molecular structure. It can be utilized in the development of new drugs targeting specific medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(5-(4-Fluorophenyl)thiophen-2-yl)ethanone is used as a key component in the formulation of various agrochemical products. Its unique properties can contribute to the effectiveness of these products in agricultural applications.
Used in Medicinal Chemistry:
1-(5-(4-Fluorophenyl)thiophen-2-yl)ethanone is used as a building block in medicinal chemistry for its potential to be incorporated into novel drug candidates. Its unique molecular structure allows for the exploration of new therapeutic avenues.
Used in Drug Development:
1-(5-(4-Fluorophenyl)thiophen-2-yl)ethanone is used in drug development as a starting material or a synthetic intermediate for creating new pharmaceuticals. Its potential biological activities and molecular diversity make it a valuable asset in the search for innovative treatments.
Used in Organic Synthesis:
1-(5-(4-Fluorophenyl)thiophen-2-yl)ethanone is used as a versatile reagent in organic synthesis, where its fluorophenyl and thiophen-2-yl groups can be exploited to create a wide range of organic compounds with various applications.
Used in Materials Science:
In materials science, 1-(5-(4-Fluorophenyl)thiophen-2-yl)ethanone is used for its potential to contribute to the development of new materials with unique properties. The thiophene ring in its structure can exhibit various characteristics that are beneficial in the synthesis of advanced materials.

Upstream product

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Relevant articles and documents

New benzimidazolium N-heterocyclic carbene precursors and their related Pd-NHC complex PEPPSI-type: Synthesis, structures, DFT calculations, biological activity, docking study, and catalytic application in the direct arylation

New benzhydryl-5,6-dimethyl-(3-methylbenzyl)benzimidazolium salt as N-heterocyclic carbene precursors and their related new Pd-NHC complex PEPPSI-type with the general formula [PdBr2(NHC)(pyridine)] were prepared and theoretically studied. Quan

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Abstract: N-Heterocyclic carbene (NHC)-linked PEPPSI-type palladium complexes have recently been used in the direct C-H bond arylation of heteroarenes. However, in most of the published works, NHC ligands containing benzimidazole and imidazole ring have b

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A Zwitterionic Palladium(II) Complex as a Precatalyst for Neat-Water-Mediated Cross-Coupling Reactions of Heteroaryl, Benzyl, and Aryl Acid Chlorides with Organoboron Reagents

The Suzuki–Miyaura cross-coupling (SMC) reactions of several heteroaryl chlorides, benzyl chlorides, and aryl acid chlorides with (hetero)arylboron reagents have been investigated in the presence of [Pd(HL1)(PPh3)Cl2] (I) [HL1 = 3-[(2,6-diisopropylphenyl)-1-imidazolio]-2-quinoxalinide] as catalyst and K2CO3 as base in neat water. The synthesis of the heterocycle-containing biaryls required the addition of 2 mol-% of a phosphine ligand (PPh3 or X-Phos). A combination of more than 115 substrates were screened and it was found that I is a versatile catalyst that can produce heterocycle-containing biaryls, diarylmethanes, and benzophenones in moderate-to-excellent yields.

Synthesis of functionalized 2-arylthiophenes with triarylbismuths as atom-efficient multicoupling organometallic nucleophiles under palladium catalysis

Atom-efficient cross-coupling reactions of functionalized 2-bromo- and 2-iodothiophenes have been demonstrated using triarylbismuths as atom-efficient multicoupling organometallic nucleophiles under palladium-catalyzed conditions. These couplings with various functionalized triarylbismuths proceeded smoothly to afford the corresponding functionalized 2-arylthiophenes in high yields. Georg Thieme Verlag Stuttgart · New York.

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Ligand-less palladium-catalyzed direct 5-arylation of thiophenes at low catalyst loadings

Ligand-less Pd(OAc)2 provides a very efficient catalyst for the direct 5-arylation of thiophene derivatives. With this catalyst, a low palladium concentration (0.1-0.001 mol%) should be employed in order to obtain high yields of coupling products. At higher concentrations a fast formation of inactive "Pd black" generally occurs. Substrates/catalysts ratios up to 100000 can be employed with the most reactive aryl bromides. A very wide variety of functional groups is tolerated on both coupling partners. The major waste of this reaction is HBr associated with KOAc. Therefore this procedure is more economically and environmentally attractive than the traditional cross-coupling procedures employing organometallic derivatives.

Direct arylation of thiophenes via palladium-catalysed C-H functionalisation at low catalyst loadings

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