926276-11-1Relevant articles and documents
Unraveling the C2-Symmetric Azatetraquinane System. Simple, Enantioselective Syntheses
Reddy, G. Sudhakar,Reddy, D. Srinivas,Corey
, p. 2258 - 2262 (2021/04/05)
Concise stereocontrolled synthetic routes to the C2-symmetric azatetraquinane 1 (or, also, the enantiomer) are described. The successful execution of the synthesis involved innovation in the methodology for [3+2] cycloaddition and stereochemical control.
PROCESS FOR PRODUCING ESTER COMPOUND
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, (2014/04/17)
Compound (1) or a salt that is useful as an intermediate for the production of a medicine, an agrochemical or the like can be produced by a process including the following steps: (A) reacting an aldehyde (2) with nitromethane to produce a nitroaldehyde; (B) reacting the nitroaldehyde with an alcohol to produce a nitroacetal; (C) reducing the nitroacetal to produce an aminoacetal; (D) protecting an amino group in the aminoacetal to produce a protected aminoacetal; (E) treating the protected aminoacetal with an acid and subsequently with a base and then reacting the resultant product with a cyanating agent to produce a nitrile; (F) hydrolyzing the nitrile to produce a protected amino acid; and (G) substituting a group R5 in the protected amino acid by a hydrogen atom and protecting a carboxyl group therein.
Enantioselective biocatalytic oxidative desymmetrization of substituted pyrrolidines
Koehler, Valentin,Bailey, Kevin R.,Znabet, Anass,Raftery, James,Helliwell, Madeleine,Turner, Nicholas J.
supporting information; experimental part, p. 2182 - 2184 (2010/06/18)
"Chemical Equation Presented" Center stage: Additions of nitrogen-centered radicals to cyanamide compounds provided the first radical synthesis of aromatic polycyclic guanidine derivatives (see scheme). Modular assembly of the substrates allows for a rapid increase of the molecular complexity of scaffolds, which have potential applications for medicinal chemistry.