929345-60-8

Basic information

• Product Name: 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid
• Synonyms: 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid
• CAS NO: 929345-60-8
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.23588
• Mol File: 929345-60-8.mol

Chemical Properties

• Appearance: /
• Density: 1.375
• CAS DataBase Reference: 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid(929345-60-8)
• EPA Substance Registry System: 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid(929345-60-8)

Safety Data

• Hazardous Substances Data: 929345-60-8(Hazardous Substances Data)

Upstream product

• 73390-11-1 4-piperidinone monohydrate 
• 619-67-0 4-Hydrazinobenzoic acid 
• 41979-39-9 4-piperidone hydrochloride 
• 24589-77-3 4-hydrazinobenzoic acid hydrochloride 

Downstream Products

• 1015082-04-8 methyl 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylate 
• 910797-04-5 tert-butyl 8-[(4-methylpiperidin-1-yl)carbonyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 1361408-14-1 C₂₈H₃₃N₃O 
• 910798-30-0 tert-butyl 5-(4-ethoxybenzyl)-8-[(4-methylpiperidin-1-yl)carbonyl]-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate 
• 910801-35-3 C₂₄H₂₇N₃O₃S 
• 910798-31-1 5-(4-ethoxybenzyl)-8-[(4-methylpiperidin-1-yl)carbonyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 
• 300715-96-2 2-(tert-butoxycarbonyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-carboxylic acid 

Relevant articles and documents

Targeting low-druggability bromodomains: Fragment based screening and inhibitor design against the BAZ2B bromodomain

Bromodomains are epigenetic reader domains that have recently become popular targets. In contrast to BET bromodomains, which have proven druggable, bromodomains from other regions of the phylogenetic tree have shallower pockets. We describe successful tar

γ-Carbolines: A novel class of cannabinoid agonists with high aqueous solubility and restricted CNS penetration

An oral, peripherally restricted CB1/CB2 agonist could provide an interesting approach to treat chronic pain by harnessing the analgesic properties of cannabinoids but without the well-known central side effects. γ-Carbolines are a novel class of potent mixed CB1/CB2 agonists characterized by attractive physicochemical properties including high aqueous solubility. Optimization of the series has led to the discovery of 29, which has oral activity in a rat inflammatory pain model and limited brain exposure at analgesic doses, consistent with a lower risk of CNS-mediated tolerability issues.

TETRAHYDRO-LH-PYRIDO [3,4 -B] INDOLE DERIVATIVES AS CBL RECEPTOR LIGANDS

The present invention provides tetrahydro-lH-pyrido [3, 4- b] indole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds act as cannabinoid receptor ligands (CB1) and thus may be used in the treatment of pain, cancer, multiple sclerosis, Parkinson's disease, Huntington's chorea, Alzheimer's disease, anxiety disorders, gastrointestinal disorders and/or cardiovascular disorders.

TETRAHYDRO-LH-PYRIDO[3,4-B] INDOLE DERIVATIVES AS CB1 RECEPTOR LIGANDS

The present invention provides tetrahydro-1H-pyrido [3,4- b] indole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds act as cannabinoid receptor ligands (CB1) and thus may be used in the treatment of pain, cancer, multiple sclerosis, Parkinson's disease, Huntington's chorea, Alzheimer's disease, anxiety disorders, gastrointestinal disorders and/or cardiovascular disorders.