944716-73-8

Basic information

• Product Name: (2S,3S)-3-AMino-N-cyclopropyl-2-hydroxyhexanaMide hydrochloride
• Synonyms: (2S,3S)-3-AMino-N-cyclopropyl-2-hydroxyhexanaMide hydrochloride;(2S,3S)-3-Amino-N-Cyclopropyl-2-Hydroxyhexanamide HCl Salt;Hexanamide, 3-amino-N-cyclopropyl-2-hydroxy-, hydrochloride (1:1), (2S,3S)-
• CAS NO: 944716-73-8
• Molecular Formula: C₉H₁₈N₂O₂*ClH
• Molecular Weight: 222.71236
• Mol File: 944716-73-8.mol

Chemical Properties

• Appearance: /
• Density: 1.17 at 20℃
• Vapor Pressure: 0Pa at 25℃
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (2S,3S)-3-AMino-N-cyclopropyl-2-hydroxyhexanaMide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-3-AMino-N-cyclopropyl-2-hydroxyhexanaMide hydrochloride(944716-73-8)
• EPA Substance Registry System: (2S,3S)-3-AMino-N-cyclopropyl-2-hydroxyhexanaMide hydrochloride(944716-73-8)

Safety Data

• Hazardous Substances Data: 944716-73-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
(2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride is used as a research compound for exploring its potential interactions with biological systems. Its unique structure and functional groups may offer novel therapeutic opportunities in the development of new drugs.
Used in Medicinal Formulations:
Due to its water solubility and stability as a hydrochloride salt, (2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride is used as an active pharmaceutical ingredient in the formulation of medications. Its properties may contribute to improved drug delivery and efficacy.
Further research is necessary to fully understand the properties and potential uses of (2S,3S)-3-Amino-N-cyclopropyl-2-hydroxyhexanamide hydrochloride, as its applications in various industries may be diverse and dependent on its specific characteristics and interactions with biological targets.

Upstream product

• 944716-71-6 (2S,3S)-N-cyclopropyl-3-(tert-butoxycarbonyl)amino-2-hydroxyhexanoic acid amide 
• 111003-36-2 ((2R,3S)-3-propyloxiran-2-yl)methanol 
• 928-95-0 (E)-2-Hexen-1-ol 
• 959709-83-2 (4S,5S)-N-cyclopropyl-2-methyl-4-propyl-4,5-dihydro-1,3-oxazole-5-carboxamide 
• 959709-91-2 (4S,5S)-N-cyclopropyl-2-isopropyl-4-propyl-4,5-dihydro-1,3-oxazole-5-carboxamide 
• 950842-31-6 (2S,3S)-3-amino-3-deutero-N-cyclopropyl-2-hydroxyhexanamide deoxycholic acid salt 

Downstream Products

• 402959-36-8 C₃₆H₅₅N₇O₆ 
• 402957-28-2 (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide 
• 1187162-81-7 (2S,4R)-tert-butyl 2-((2S,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-ylcarbamoyl)-4-(7-methoxy-2-(1H-pyrazol-1-yl)quinolin-4-yloxy)pyrrolidine-1-carboxylate 

Relevant articles and documents

Asymmetric synthesis of 3,4-disubstituted proline derivatives: Application in synthesis of hepatitis C virus protease inhibitor telaprevir

A practical asymmetric synthesis of 3,4-disubstituted proline derivatives has been realized with high stereoselectivity and moderate yield. The key steps involved are desymmetric ring-opening reaction of commercially available anhydrides, intramolecular Strecker reaction and thermodynamically controlled cyanide hydrolysis. Based on this methodology, the synthesis of HCV protease inhibitor Telaprevir was achieved.

PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 3-AMINO-2 -HYDROXYPROPIONIC CYCLOPROPYLAMIDE DERIVATIVES AND SALTS THEREOF

An objective of the present application is to provide an industrially practicable method for producing an optically-active 3-amino-2-hydroxypropionic cyclopropylamide derivative or salt thereof from an inexpensive easily-available starting material. The derivative or salt thereof is useful as an intermediate for a medicine. It is also intended by the present application to provide a useful intermediate of the derivative. The objective is attained by the following method. First, an easily-available 2-halo-3-oxopropionic acid derivative is asymmetrically reduced, and then epoxidated to produce an optically-active epoxycarboxylic acid derivative. Next, the derivative is converted into an optically-active epoxyamide derivative by reaction with cyclopropylamine, and then reacted with a nitrile to obtain an optically-active oxazolinamide derivative. Subsequently, selective acid solvolysis of the oxazoline skeleton gives the optically-active 3-amino-2-hydroxypropionic cyclopropylamide derivative or salt thereof.

PROCESS FOR PRODUCTION OF BETA-AMINO-ALPHA-HYDROXY ACID AMIDE DERIVATIVE

Provided is a process for production of a β-amino-α-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a β-(N-protected)amino-α-hydroxycarboxylic acid is reacted with an amine to conversion to a β-(N-protected)amino-α-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a β-amino-α-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity β-amino-α-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process.

Process for preparing beta-amino-alpha-hydroxycarboxamides

The present invention is directed to a process for preparing β-amino-α-hydroxycarboxamides. The process works with epoxycarboxamides of the formula 2 which are reacted with ammonia or other amines.

Deuterated hepatitis C protease inhibitors

A deuterated α-ketoamido steric specific compound of the formula wherein D denotes a deuterium atom on a steric specific carbon atom.