945608-15-1

Basic information

• Product Name: 1H-PYRROLO[2,3-B]PYRIDINE,3-IODO-1-METHYL-2-PHENYL-
• Synonyms: 1H-PYRROLO[2,3-B]PYRIDINE,3-IODO-1-METHYL-2-PHENYL-;3-iodo-1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine
• CAS NO: 945608-15-1
• Molecular Formula: C₁₄H₁₁IN₂
• Molecular Weight: 334.15
• Mol File: 945608-15-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-PYRROLO[2,3-B]PYRIDINE,3-IODO-1-METHYL-2-PHENYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRROLO[2,3-B]PYRIDINE,3-IODO-1-METHYL-2-PHENYL-(945608-15-1)
• EPA Substance Registry System: 1H-PYRROLO[2,3-B]PYRIDINE,3-IODO-1-METHYL-2-PHENYL-(945608-15-1)

Safety Data

• Hazardous Substances Data: 945608-15-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
1H-Pyrrolo[2,3-b]pyridine,3-iodo-1-methyl-2-phenylis used as a key intermediate in the synthesis of biologically active molecules for pharmaceutical research. Its unique structure allows for the development of compounds with potential therapeutic effects against various diseases.
Used in Organic Synthesis:
In the field of organic synthesis, 1H-Pyrrolo[2,3-b]pyridine,3-iodo-1-methyl-2-phenylserves as a valuable building block for creating a wide range of chemical compounds. Its versatility in forming different chemical bonds and its stability make it an ideal candidate for various synthetic pathways.
Used in Antiviral Drug Development:
1H-Pyrrolo[2,3-b]pyridine,3-iodo-1-methyl-2-phenylis used as a starting material in the development of antiviral agents. Its structure can be modified to target specific viral enzymes or processes, potentially leading to the creation of new antiviral drugs.
Used in Anticancer Drug Development:
1H-Pyrrolo[2,3-b]pyridine,3-iodo-1-methyl-2-phenylis also utilized in the development of anticancer drugs. Its unique chemical properties can be harnessed to design molecules that target cancer cells specifically, leading to the creation of more effective and targeted cancer therapies.
Used in Antibacterial Drug Development:
1H-Pyrrolo[2,3-b]pyridine,3-iodo-1-methyl-2-phenylis used in the research and development of new antibacterial agents. Its potential to be modified and its ability to interact with bacterial processes make it a promising candidate for creating novel antibiotics to combat drug-resistant bacteria.
Used in Neurodegenerative Disease Treatment Research:
In the medical field, 1H-Pyrrolo[2,3-b]pyridine,3-iodo-1-methyl-2-phenylis studied for its potential role in the treatment of neurodegenerative diseases. Its unique structure may allow for the development of compounds that can target and alleviate the symptoms of such conditions, offering new therapeutic options for patients.

Upstream product

• 214342-66-2 3-iodo-N,N-dimethyl-pyridin-2-amine 
• 113975-22-7 2-fluoro-3-iodopyridine 
• 13534-99-1 2-Amino-3-bromopyridine 
• 536-74-3 phenylacetylene 
• 74-88-4 methyl iodide 
• 10586-52-4 2-phenyl-1H-pyrrolo[2,3-b]pyridine 
• 98-88-4 benzoyl chloride 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 23612-46-6 N-(3-methylpyridin-2-yl)benzamide 
• 116026-94-9 2--3-pyridinecarboxaldehyde 
• 945607-77-2 [3-(2,2-dichlorovinyl)-pyridin-2-yl]-methyl-amine 
• 945607-94-3 C₁₃H₁₆Cl₂N₂O₂ 
• 945607-75-0 [3-(2,2-dibromovinyl)-pyridin-2-yl]-methyl-amine 
• 1009104-87-3 C₁₃H₁₆Br₂N₂O₂ 

Downstream Products

• 1009104-85-1 ((E)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one) 
• 1439397-11-1 1-(4-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)cyclobutanamine 
• 1439397-16-6 tert-butyl 1-(4-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)cyclobutylcarbamate 
• 1009104-85-1 SIS₃ 

Relevant articles and documents

Synthesis of 3-Halo-7-azaindoles through a 5- endo -dig Electrophilic Cyclization Reaction

Biologically useful 7-azaindoles were synthesized by electrophilic cyclization of 3-alkynyl- N, N -dimethylpyridine-2-amines with molecular iodine. By this simple atom-economical approach under ambient reaction conditions, a library of interesting 3-iodo-7-azaindoles were synthesized in high yields. To synthesize the corresponding 3-bromo- and 3-chloro-7-azaindoles, an environmentally benign copper-mediated cyclization was employed, with inexpensive, nontoxic, and noncorrosive sodium chloride and sodium bromide as the sources of chlorine and bromine, respectively.

One-Pot Coupling-Cyclization-Alkylation Synthesis of 1,2,5-Trisubstituted 7-Azaindoles in a Consecutive Three-component Fashion

1,2,5-Trisubstituted 7-azaindoles are rapidly and efficiently prepared in a one-pot, copper-free alkynylation-cyclization-alkylation sequence starting from unprotected 2-aminopyridyl halides in a consecutive three-component fashion. By extension to a consecutive four-component coupling-cyclization-iodination-alkylation synthesis of 3-iodo-1-methyl-2-phenyl-1 H -pyrrolo[2,3- b ]pyridine, a concise synthesis of SIS3, a selective TGF-β1 and signaling inhibitor, was realized.

BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula 1: wherein Het, X, R1 and R2 are as defined herein.

2-SUBSTITUTED AZAIN DOLES AND 2 SUBSTITUTED THIENOPYRROLES, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF

The present invention relates generally to processes for the chemical synthesis of azaindole and thienopyrrole compounds, in particular azaindole and thienopyrrole compounds that are substituted at the 2-position of the azaindole or thienopyrrole ring, an

A general modular method of azaindole and thienopyrrole synthesis via Pd-catalyzed tandem couplings of gem-dichloroolefins

(Chemical Equation Presented) A palladium-catalyzed reaction of gem-dichloroolefins and a boronic acid via a tandem intramolecular C-N and intermolecular Suzuki coupling process gave corresponding substituted azaindoles or thienopyrroles. This method is a