23612-46-6

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
N-(3-Methyl-2-pyridyl)benzamide is used as a building block in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new drugs and chemical products.
Used in Organic Chemistry:
N-(3-Methyl-2-pyridyl)benzamide is used as a reagent in the preparation of various organic compounds, facilitating the synthesis of complex molecules and enhancing chemical reactions.
Used in Medicinal Chemistry and Material Science:
Due to its unique chemical structure and properties, N-(3-Methyl-2-pyridyl)benzamide may have potential applications in medicinal chemistry and material science, offering new avenues for research and innovation.
However, it is important to note that the toxicological properties and potential hazards of N-(3-Methyl-2-pyridyl)benzamide have not been widely studied. Therefore, precautions should be taken when handling N-(3-Methyl-2-pyridyl)benzamide to ensure safety and minimize risks.

InChI:InChI=1/C13H12N2O/c1-10-6-5-9-14-12(10)15-13(16)11-7-3-2-4-8-11/h2-9H,1H3,(H,14,15,16)

Upstream product

• 1603-40-3 3-methylpyridin-2-ylamine 
• 98-88-4 benzoyl chloride 
• 93-97-0 benzoic acid anhydride 
• 100-52-7 benzaldehyde 
• 536-74-3 phenylacetylene 
• 98-86-2 acetophenone 
• 98-85-1 1-Phenylethanol 
• 70-11-1 α-bromoacetophenone 
• 100-41-4 ethylbenzene 
• 102-96-5 (2-nitroethenyl)benzene 

Downstream Products

• 10586-52-4 2-phenyl-1H-pyrrolo[2,3-b]pyridine 
• 1427204-31-6 N-(dimethylcarbamoyl)-N-(3-methylpyridin-2-yl)benzamide 
• 945608-15-1 3-iodo-1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridine 
• 1439397-16-6 tert-butyl 1-(4-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)cyclobutylcarbamate 
• 1439397-11-1 1-(4-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl)cyclobutanamine 
• 4931-20-8 8-methyl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridine 

Relevant academic research and scientific papers

Direct Transformation of Alkylarenes into N-(Pyridine-2-yl)amides by C(sp3)–C(sp3) Bond Cleavage

C(sp3)–H bond functionalization and C(sp3)–C(sp3) bond cleavage are very challenging transformations in chemistry. Herein, we report a mild and green methodology for the construction of N-(pyridine-2-yl)amides via tandem C(sp3)–H activation/C–C bond cleavage of alkylarenes. Various N-heterocyclic amides were directly synthesized from alkylarenes in water in moderate to good yields.

Chemodivergent synthesis of: N -(pyridin-2-yl)amides and 3-bromoimidazo[1,2- a] pyridines from α-bromoketones and 2-aminopyridines

N-(Pyridin-2-yl)amides and 3-bromoimidazo[1,2-a]pyridines were synthesized respectively from α-bromoketones and 2-aminopyridine under different reaction conditions. N-(Pyridin-2-yl)amides were formed in toluene via C-C bond cleavage promoted by I2/s

Metal-Free Synthesis of N-(Pyridine-2-yl)amides from Ketones via Selective Oxidative Cleavage of C(O)-C(Alkyl) Bond in Water

The TBHP/TBAI-mediated synthesis of N-(pyridine-2-yl)amides in water from ketones and 2-aminopyridine via direct oxidative C-C bond cleavage has been developed. A series of ketones, including more challenging inactive aromatic ketones substituted with div

Ce(III)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants

An efficient synthesis of a variety of pyridyl benzamides from 2-aminopyridines and nitroolefins is described. This rare-earth-metal-catalyzed reaction provides the corresponding products with broad substrate scope in moderate to excellent yields, in the absence of additives and external oxidants. Water is used as the source of the carbonyl oxygen atom in pyridyl benzamides. Furthermore, 2-substituted oxazolo[4,5-b]pyridines are formed in good yields under the standard conditions when 2-aminopyridin-3-ols are used as the substrates.

Synthesis method of N-heterocyclic acylamide derivative

The invention discloses a synthesis method of an N-heterocyclic acylamide derivative. A reaction general formula is as shown in the specification. According to the synthesis method, an imidazo heterocyclic amine compound I is taken as a raw material; unde

Copper(i)-catalysed oxidative C-N coupling of 2-aminopyridine with terminal alkynes featuring a CC bond cleavage promoted by visible light

Facile visible-light promoted copper-catalyzed aerobic oxidative C-N coupling between 2-aminopyridine and terminal alkynes at room temperature via CC triple bond cleavage is described. This reaction allows direct synthesis of biologically important pyridy

Microwave-assisted heteropolyanion-based ionic liquid promoted sustainable protocol to N-heteroaryl amides via N-directing dual catalyzed oxidative amidation of aldehydes

A sustainable procedure for the synthesis of N-heteroaryl amides directly from oxidative amidation of aldehydes catalyzed by heteropolyanion-based ionic liquids under microwave-promoted conditions has been reported. The transformation has proven to tolerate a wide range of aldehydes and amino heterocycles with different functional groups. Moderate to excellent yields, solvent-free media, operational simplicity and reusability of catalysts are the main highlights. Furthermore, the proposed N-directing dual-catalysis mechanistic pathway was briefly investigated in this report.

Metal-free oxidative amidation of aldehydes with aminopyridines employing aqueous hydrogen peroxide

The first metal free report on the amidation of aldehydes with aminopyridines was accomplished using simple aqueous hydrogen peroxide (aq. H2O2) as the oxidant. No catalysts or additives were needed for this transformation and the reaction proceeded in water, an environmentally benign reaction medium. Green oxidant and reaction conditions, and the ability to construct diverse N-(pyridin-2-yl)benzamide by this elegant method render it a practical alternative for the synthesis of these amides.

BICYCLIC HETEROARYL DERIVATIVES AS KINASE INHIBITORS

The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula 1: wherein Het, X, R1 and R2 are as defined herein.

Efficient synthesis of 2-substituted 7-azaindole derivatives via palladium-catalyzed coupling and C-N cyclization using 18-crown-6

A practical and straightforward preparation of various novel 2-substituted 7-azaindole derivatives from 2-amino-3-iodopyridine by a two-step procedure is described that gives the desired compounds in good overall yields. Georg Thieme Verlag Stuttgart.