95-70-5

Basic information

• Product Name: 2,5-Diaminotoluene
• Synonyms: 2,5-DIAMINO TOLUENE FREE;2-Methyl-1,4-phenylene diamine;1-METHYL-2,5-DIAMINOBENZENE;DIAMINOTOLUENES;4-TOLUYLENEDIAMINE;1,4-DIAMINO-2-METHYLBENZENESULFATE;TOLUENE-2,5-DIAMINE(ANDITSSALTS);2-methyl-p-phenylenediamine 2,5-toluenediamine
• CAS NO: 95-70-5
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.17
• EINECS: 202-442-1
• Product Categories: Intermediates of Dyes and Pigments
• Mol File: 95-70-5.mol

Chemical Properties

• Melting Point: 64°C
• Boiling Point: 273°C
• Flash Point: 140.6 °C
• Appearance: purple crystal
• Density: 1.0343 (rough estimate)
• Vapor Pressure: 0.00565mmHg at 25°C
• Refractive Index: 1.5103 (estimate)
• Solubility: Soluble in water
• PKA: 5.98±0.10(Predicted)
• Water Solubility: 500g/L at 20℃
• CAS DataBase Reference: 2,5-Diaminotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Diaminotoluene(95-70-5)
• EPA Substance Registry System: 2,5-Diaminotoluene(95-70-5)

Safety Data

• Hazard Codes: T,N
• Statements: 20/21-25-43-51/53
• Safety Statements: 24-37-45-61
• RIDADR: 2811
• RTECS: XS9700000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 95-70-5(Hazardous Substances Data)

Usage

Uses

Used in Hair Dye Industry:
2,5-Diaminotoluene is used as a major oxidation dye precursor in hair dye formulations, providing color and enhancing the dyeing process.
Used in Dye Synthesis:
It is also utilized in the synthesis of saframine, a family of dyes used as biological stains, and may be present in indelible ink, antifreeze, and nail polish.
Occupational Exposure:
Hairdressers, barbers, and workers in the dye manufacturing industry may be exposed to 2,5-Diaminotoluene due to its widespread use in hair dye formulations and other dye-related products.

Synthesis Reference(s)

Journal of the American Chemical Society, 102, p. 6182, 1980 DOI: 10.1021/ja00539a054

Flammability and Explosibility

Nonflammable

Contact allergens

Toluene-2,5-diamine is a permanent hair dye involved in contact dermatitis in hairdressers and consumers. It does not cross-react with PPD, but cosensitization is frequent.

Safety Profile

Poison by ingestion and subcutaneous routes. A skin irritant. Mutation data reported. Questionable carcinogen. Has a toxic action upon the liver and can cause fatty degeneration of that organ. Its total effect upon the body seems to take place three chfferent ways. It is toxic to the central nervous system, producing jaundice by action on the liver and spleen, and anemia by destruction of the red blood cells. This action is quite similar to that of aniline, although by no means identical with it. Its high boiling point and the fact that the material is solid at room temperature make it somewhat less hazardous than aniline, particularly at ordinary working temperatures. The literature contains a reference to a permanent injury to an eye due to the use of this material as an eyelash dye. It is considered to be an irritating dye material. When heated to decomposition it emits toxic fumes of NOx. See also other toluene diamine entries and AROMATIC AMINES.

Carcinogenicity

The possible carcinogenicity of 2,5-TDA (as sulfate salt [6369-59-1]) was tested by the National Cancer Institute in a dietary feeding study. Groups of 50 male and female F344 rats (600 or 2000 ppm) and B6C3F1 mice (600 or 1000 ppm) were given diets containing 2,5-TDA for 78 weeks and then observed for an additional period of 28–31 weeks for rats and 16–19 weeks for mice. The only statistically significant increased incidence was in lung tumors in high-dose female mice, but the evidence was not convincing enough to be attributed to 2,5-TDA. Overall, the compound was considered noncarcinogenic.

InChI:InChI=1/C7H10N2.ClH/c1-5-4-6(8)2-3-7(5)9;/h2-4H,8-9H2,1H3;1H

Upstream product

• 99-52-5 2-methyl-4-nitro-benzenamine 
• 7647-01-0 hydrogenchloride 
• 611-05-2 4-nitro-3-methylaniline 
• 36164-91-7 toluquinone dioxime 
• 872821-37-9 N'-(3-methyl-4-m-tolylazo-phenyl)-hydrazine-sulfonic acid 
• 64-19-7 acetic acid 
• 16714-19-5 1-azido-2-methyl-4-nitrobenzene 
• 121-14-2 2,4-dinitrotoluene 
• 618-85-9 3,5-dinitrotoluene 
• 606-20-2 2,6-dinitrotoluene 
• 602-01-7 1-methyl-2,3-dinitrobenzene 
• 610-39-9 3,4-Dinitrotoluene 
• 619-15-8 2,5-dinitrotoluene 
• 95-53-4 o-toluidine 

Downstream Products

• 19039-27-1 2,5-diacetylaminotoluene 
• 6375-20-8 N-(4-Amino-3-methyl-phenyl)-acetamide 
• 56891-59-9 N-(4-Amino-2-methyl-phenyl)-acetamide 
• 112717-68-7 N,N'-(methyl-p-phenylene)-bis-benzamide 
• 200348-81-8 N-(2-methyl-4-((phenylsulfonyl)amino)phenyl)benzenesulfonamide 
• 614-90-4 toluene-2,5-diisocyanate 
• 19398-61-9 2,5-dichlorotoluene 
• 3029-60-5 N,N'-dichloro-2-methyl-cyclohexa-2,5-diene-1,4-diylidenediamine 
• 90932-85-7 methyl-[1,4]benzoquinone-bis-bromoimine 
• 553-97-9 2-Methyl-1,4-benzoquinone 
• 14818-63-4 Di-trifluoracetyl-diaminotoluol-(2,5) 
• 69950-77-2 C₁₇H₃₀N₄O₆P₂S₂ 
• 72255-63-1 6-(4-Amino-3-methyl-phenylamino)-1H-pyrimidine-2,4-dione 
• 126314-32-7 2-methylbenzene-1,4-di-4'-morpholine 

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