98923-21-8

Basic information

• Product Name: 3-aminopropane-1,2-diol
• Synonyms: 3-AMinopropan-1,2-diol
• CAS NO: 98923-21-8
• Molecular Formula: C3H9NO2
• Molecular Weight: 0
• Mol File: 98923-21-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-aminopropane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-aminopropane-1,2-diol(98923-21-8)
• EPA Substance Registry System: 3-aminopropane-1,2-diol(98923-21-8)

Safety Data

• Hazardous Substances Data: 98923-21-8(Hazardous Substances Data)

Upstream product

• 93372-65-7 2-hydroxy-3-methoxypropylamine 
• 818-63-3 N-(2,3-dibromo-propyl)-acetamide 
• 556-52-5 oxiranyl-methanol 
• 96-24-2 3-monochloro-1,2-propanediol 
• 7664-41-7 ammonia 
• 7732-18-5 water 
• 62037-46-1 rac-1-amino-3-chloro-2-propanol hydrochloride 
• 56-82-6 Glyceraldehyde 
• 22195-47-7 4-aminomethyl-2,2-dimethyl[1,3]dioxolane 
• 41274-09-3 (R)-3-tosyloxy-1,2-propanediol 
• 123356-17-2 (S)-3-Benzyloxy-2-hydroxy-propionitrile 
• 82954-65-2 [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methanamine 
• 57044-25-4 (R)-oxiranemethanol 
• 85820-82-2 (S)-1-azido-1-deoxy-2,3-O-isopropylidene-glycerol 

Downstream Products

• 858009-93-5 3-(4,5-dimethyl-2-nitro-anilino)-propane-1,2-diol 
• 78213-38-4 3-(5-chloro-2-nitro-anilino)-propane-1,2-diol 
• 100132-79-4 N-(2,3-dihydroxy-propyl)-toluene-4-sulfonamide 
• 209531-97-5 N-(2,3-dihydroxypropyl)octadecanamide 
• 90559-79-8 3-(2,4-dinitro-anilino)-propane-1,2-diol 
• 90648-98-9 p-(2,3-Dihydroxypropylsulfamoyl)benzolsulfonamid 
• 34450-03-8 C₂₃H₂₁N₅O₈ 
• 34450-02-7 C₂₇H₂₁N₅O₁₁ 
• 82954-62-9 N-Benzyloxycarbonyl-(S)-alanin-<(S)-2,3-dihydroxypropylamid> 
• 82954-67-4 N-Benzyloxycarbonyl-(S)-alanin-<(R)-2,3-dihydroxypropylamid> 
• 82954-63-0 N-Benzyloxycarbonyl-(S)-valin-(2,3-dihydroxypropylamid) 
• 17462-08-7 N-Benzyloxycarbonyl-(S)-phenylalanin-(2,3-dihydroxypropylamid) 
• 88413-18-7 N-[3-(2,3-Dihydroxy-propylamino)-4-nitro-phenyl]-methanesulfonamide 
• 82954-61-8 N-(Benzyloxycarbonyl)glycin-(2,3-dihydroxypropylamid) 

Relevant articles and documents

Stereoselective Oxidative Cyclization ofN-Allyl Benzamides to Oxaz(ol)ines

This study presents an enantioselective oxidative cyclization ofN-allyl carboxamides via a chiral triazole-substituted iodoarene catalyst. The method allows the synthesis of highly enantioenriched oxazolines and oxazines, with yields of up to 94% and enantioselectivities of up to 98% ee. Quaternary stereocenters can be constructed and, besidesN-allyl amides, the corresponding thioamides and imideamides are well tolerated as substrates, giving rise to a plethora of chiral 5-memberedN-heterocycles. By applying a multitude of further functionalizations, we finally demonstrate the high value of the observed chiral heterocycles as strategic intermediates for the synthesis of other enantioenriched target structures.

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The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.

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Process for the hydrolysis or alcoholysis of a ketal or acetal compound wherein a ketal or acetal compound comprising at least one ketal or acetal group and at least one amino group is reacted with carbon dioxide and water oran alcohol.

PROCESS FOR THE PREPARATION OF A 3-AMINO-1,2-PROPANDIOL AND DERIVATIVES THEREOF

Process for the preparation of a compound of formula (I) with R1 and R2 independently from each other representing hydrogen or a C1-to C10 alkyl group by a two-step process wherein the first step is an amination of the compound of formula (II) with an amino compound HNR1 R2 in the presence of hydrogen and resulting in the compound of formula (III) and the second step is a ring-cleaving of the compound of formula (III) giving the compound of formula (I).

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Transformation of biomass into valuable nitrogen-containing compounds is highly desired, yet limited success has been achieved. Here we report an efficient catalyst system, partially reduced Ru/ZrO2, which could catalyze the reductive amination of a variety of biomass-derived aldehydes/ketones in aqueous ammonia. With this approach, a spectrum of renewable primary amines was produced in good to excellent yields. Moreover, we have demonstrated a two-step approach for production of ethanolamine, a large-market nitrogen-containing chemical, from lignocellulose in an overall yield of 10 %. Extensive characterizations showed that Ru/ZrO2-containing multivalence Ru association species worked as a bifunctional catalyst, with RuO2 as acidic promoter to facilitate the activation of carbonyl groups and Ru as active sites for the subsequent imine hydrogenation.

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A method for preparing polyamine by direct ammoniation of a polyhydroxy compound is disclosed. By using a polyhydroxy compound, ammonia gas or liquefied ammonia as a raw material and using a carrier-loaded liquid-phase reduced transition metal as a catalyst, an ammoniation reaction of the polyhydroxy compound under mild conditions is realized. The catalyst has high selectivity of polyamine. The catalyst can be recovered and recycled.

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The invention belongs to the chemical field, particularly relates to a production and synthesis technology of a medical intermediate, and provides a preparation method of 3-amino-1,2-propanediol mainly aiming at a 3-amino-1,2-propanediol product. The preparation method of 3-amino-1,2-propanediol adopts epichlorohydrin and ammonia water as the main raw materials, a two-component catalyst is used in a hydrolysis reaction process and an ammoniation reaction process respectively, the reaction temperature in earlier period and later period in a hydrolysis reaction kettle is increased in a segmented manner, the reaction selectivity is improved, side effects are reduced, the reaction rate is increased, the reaction time is shortened, and energy consumption is reduced. The specific operation flow of the preparation method comprises the hydrolysis reaction, neutralization, distillation, ammoniation reaction, filtering, distillation, centrifugation and rectification. Meanwhile, the catalyst can be recycled and the cost can be saved, and the preparation method further has the advantages of high safety, stable product quality, high purity and the like.

A concise stereoselective synthesis of (+)-1-deoxy-6-epi-castanospermine

A concise stereoselective synthesis of (+)-1-deoxy-6-epi-castanospermine has been developed through stereoselective approach from the chiral precursor R-Glycidol. The key steps in the synthesis involve Grignard reaction through Weinreb amide, followed by Sharpless dihydroxylation and stereoselective reduction of imine assigned the required stereochemical feature of indolizidine azasugar (+)-1-deoxy-6-epi-castanospermine.

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