100416-57-7

Basic information

• Product Name: ethyl 6-chloro-2-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate
• Synonyms: ethyl 6-chloro-2-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate
• CAS NO: 100416-57-7
• Molecular Weight: 278.738
• Mol File: 100416-57-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 6-chloro-2-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 6-chloro-2-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate(100416-57-7)
• EPA Substance Registry System: ethyl 6-chloro-2-methyl-4-phenyl-1,4-dihydropyrimidine-5-carboxylate(100416-57-7)

Safety Data

• Hazardous Substances Data: 100416-57-7(Hazardous Substances Data)

Upstream product

• 96962-33-3 ethyl 2-methyl-4-phenyl-1,4,5,6-tetrahydropyrimidin-6-one-5-carboxylate 
• 5292-53-5 diethyl benzalmalonate 
• 105-53-3 diethyl malonate 
• 100-52-7 benzaldehyde 

Downstream Products

• 1337541-30-6 1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-32-8 1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-o-tolyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-33-9 1-tert-butyl 5-ethyl 4-p-methoxyphenyl-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-34-0 1-tert-butyl 5-ethyl 2-methyl-4-p-nitrophenyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-35-1 1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-trans-styryl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-36-2 1-tert-butyl 5-ethyl 4-ethyl-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-37-3 1-tert-butyl 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-38-4 5-ethyl 2-methyl-4,6-diphenyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-39-5 5-ethyl 2-methyl-6-(2-methyl)phenyl-4-phenyl-1,4-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-40-8 5-ethyl 2-methyl-4-(4-methoxy)phenyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-41-9 5-ethyl 2-methyl-4-(4-nitro)phenyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-42-0 5-ethyl 2-methyl-4-trans-styryl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-43-1 5-ethyl 4-ethyl-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate 
• 1337541-44-2 5-ethyl 2-methyl-6-phenyl-4-(thiophen-3-yl)-1,6-dihydropyrimidine-1,5-dicarboxylate 

Relevant articles and documents

Synthesis and substitution reactions of 4(6)-chlorodihydropyrimidines

Chlorination of the corresponding ketones with phenylphosphonic dichloride (PhPOCl2) provided ethyl 6(4)-chloro-2-methyl-4(6)-phenyl-1,4(6)- dihydropyrimidine-5-carboxylate in good yield. The cross-coupling reactions of organoboronic acids or t