1034-49-7Relevant articles and documents
Porphyrin dimers linked by conjugated butadiynes
Arnold, Dennis P.,Nitschinsk, Lisa J.
, p. 8781 - 8792 (1992)
1,3-Butadiynes R---C≡C---C≡C---R, where R = 5′-substituted nickel(II) octaethylporphyrin (NiOEP) (1e), 2′-substituted nickel(II) 5′, 10′, 15′, 20′-tetraphenylporphyrin (NiTPP) (4e), and 2′-substituted nickel(II) heptaethylporphyrin (NiHEP) (5d), have been prepared from the respective bromovinyl species by dehydrobromination and oxidative coupling. The published synthesis of (1e) has been improved to achieve a 40% yield for four steps from NiOEP. The metal-free bis(OEP) diyne was prepared by acid treatment of (1e), while more strenuous conditions led to a novel furan substituted at the 2- and 5-positions with OEP units. The visible absorption spectra of the 5′- and 2′-substituted diynes differ markedly, the former compounds exhibiting split absorption bands and red shifts indicative of extensive chromophore interaction.
Biradical intermediate in the [2 + 2] photocycloaddition of dienes and alkenes to [60]fullerene
Hatzimarinaki, Maria,Roubelakis, Manolis M.,Orfanopoulos, Michael
, p. 14182 - 14183 (2005)
The photocycloaddition of vinylcyclopropanes to C60 yields stereospecifically a five-membered [60]fullerene adduct. These results suggest a biradical intermediate of the [2 + 2] photocycloaddition between dienes or arylalkenes and C60. An electron transfer between the triplet excited state of C60 and the unsaturated substrates precedes the formation of the intermediate. Copyright
Preparation method of benzofuran derivative
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Paragraph 0064; 0066; 0073, (2020/02/06)
The invention discloses a preparation method for synthesizing a benzofuran derivative. The specific implementation method is as shown in the specification. The method has novel synthetic route, simpleand convenient operation, high yield, and good safety, and is suitable for industrial production. A novel synthetic method of an intermediate VI is also designed, a Wittig reaction is carried out, and then ring-closing is carried out to obtain a benzofuran ring.
Highly Enantioselective Synthesis of Propargyl Amide with Vicinal Stereocenters through Ir-Catalyzed Hydroalkynylation
Li, Bi-Jie,Zhang, Su-Lei,Zhang, Wen-Wen
supporting information, p. 6874 - 6880 (2020/03/19)
Chiral propargyl amines are valuable synthetic intermediates for the preparation of biologically active compounds and functionalized amines. Catalytic methods to access propargyl amines containing vicinal stereocenters with high diastereoselectivity are particularly rare. We report an unprecedented strategy for the synthesis of enantioenriched propargyl amines with two stereogenic centres. An iridium complex, ligated by a phosphoramidite ligand, catalyzes the hydroalkynylation of β,β-disubstituted enamides to afford propargyl amides in a highly regio-, diastereo-, and enantioselective fashion. Stereodivergent synthesis of all four possible stereoisomers was achieved using this strategy.
Synthesis and evaluation of various heteroaromatic benzamides as analogues of –ylidene-benzamide cannabinoid type 2 receptor agonists
Moir, Michael,Boyd, Rochelle,Gunosewoyo, Hendra,Montgomery, Andrew P.,Connor, Mark,Kassiou, Michael
supporting information, (2019/08/12)
The CB2 receptor is an attractive target for the treatment of a wide range of diseases and pathological conditions. Compounds that selectively activate the CB2 receptor are desirable as this avoids CB1-mediated psychoactive effects. Heteroarylidene-benzamides have demonstrated efficacy as selective CB2 receptor agonists. We aimed to expand the structure-activity relationship studies of this series of compounds by investigating the heteroaromatic core via the synthesis and in vitro evaluation of a small library of various heteroaromatic benzamide analogues. As heteroaromatic amides are privileged scaffolds in drug design, methods to synthesise them are of interest. Concise and reliable synthetic strategies were developed to access these novel analogues. The –ylidene-benzamide moiety is shown to be essential for CB activity as all amide derivatives exhibit no functional activity at either CB2 or CB1 receptors.
Stereoselective Synthesis of Vinyl Iodides through Copper(I)-Catalyzed Finkelstein-Type Halide-Exchange Reaction
Feng, Xiujuan,Zhang, Haixia,Lu, Wenbo,Yamamoto, Yoshinori,Almansour, Abdulrahman I.,Arumugam, Natarajan,Kumar, Raju Suresh,Bao, Ming
supporting information, p. 2727 - 2732 (2017/06/13)
An efficient method for the stereoselective synthesis of vinyl iodides is described. The reactions of vinyl bromides with potassium iodide proceed smoothly in the presence of a copper catalyst under mild reaction conditions to produce the corresponding vinyl iodides stereospecifically and in satisfactory to excellent yields.
Protecting group free, stereocontrolled synthesis of β-halo-enamides
Pasqua, Adele E.,Crawford, James J.,Long, De-Liang,Marquez, Rodolfo
experimental part, p. 2149 - 2158 (2012/05/20)
Enamides, dienamides, and enynamides are important building blocks in synthetic, biological, and medicinal chemistry as well as materials science. Despite the extensive breath of their potential utility in synthetic chemistry, there is a lack of simple, high-yielding methods to deliver them efficiently and as single isomers. In this paper, we present a novel, protecting group free, efficient, and stereoselective approach to the generation of β-halo-enamides. The methodology presented provides a robust synthetic platform from which E- or Z-enamides can be generated in good yields and with complete stereocontrol.
Construction of 2,3-dihydrofuran cores through the [3+2] cycloaddition of gold α-carbonylcarbenoids with alkenes
Li, Chia-Wen,Lin, Guan-You,Liu, Rai-Shung
supporting information; experimental part, p. 5803 - 5811 (2010/08/20)
Treatment of 2-epoxy-1-alkynylbenzenes with electron-rich alkenes and a [AuCl(PR3)]/AgX catalyst in CH2Cl2 led to the formation of 2-alkenyl-1-(2,3-dihydrofuran-4-yl)benzenes. This transformation comprises of a gold-catalyzed redox reaction to form a gold α- carbonylcarbenoid initially, which then reacts in situ with an alkene in a [3+2] cycloaddition. A range of alkenes are amenable to this tandem reaction, amongst them α-sub-stituted styrenes, enol ethers, and 2,3dimethylbutadienes. Deuterium-labeling experiments suggest a stepwise mechanism for the α-carbonylcarbenoid/alkene [3+2] cycloaddition. The resulting 2,3-dihydrofuran products allow access to diverse oxacyclic compounds through a stereoselective ene-oxonium reaction initiated by treatment with HOTf (1mol%; Tf= trifluoromethanesulfonyl). A stepwise pathway is proposed for this reaction. The feasibility for direct transformation of 2-alkenyl-1-alkynylbenzenes into the desired 2,3-dihydrofuran products through initial m-chloroperbenzoic acid oxidation, followed by the addition of gold catalyst and alkene, has also been demonstrated.
Benzothiazole-based fluorophores of donor-π-acceptor-π-donor type displaying high two-photon absorption
Hrobarikova, Veronika,Hrobarik, Peter,Gajdos, Peter,Fitilis, Ioannis,Fakis, Mihalis,Persephonis, Peter,Zahradnik, Pavol
experimental part, p. 3053 - 3068 (2010/07/15)
A series of novel heterocycle-based dyes with donor-π-bridge-acceptor- π-bridge-donor (D-π-A-π-D) structural motif, where benzothiazole serves as an electron-withdrawing core, have been designed and synthesized via palladium-catalyzed Sonogashira and Suzuki-type cross-coupling reactions. All the target chromophores show strong one-photon and two-photon excited emission. The maximum two-photon absorption (TPA) cross sections ΔTPA of the prepared derivatives bearing diphenylamino functionalities occur at wavelengths ranging from 760 to 800 nm and are as large as ～900-1100 GM. One- and two-photon absorption characteristics of the title dyes have also been investigated by using density functional theory (DFT) and the structure-property relationships are discussed. The TPA cross sections calculated by means of quadratic response time-dependent DFT using the Coulomb-attenuated CAM-B3LYP functional support the experimentally observed trends within the series, as well as higher ΔTPA values of the title compounds compared to those of analogous fluorene or carbazole-derived dyes. In contrast, the traditional B3LYP functional was not successful in predicting the observed trend of TPA cross sections for systems with different central cores. In general, structural modification of the π-bridge composition by replacement of ethynylene (alkyne) with E-ethenylene (alkene) linkages and/or replacement of dialkylamino electron-donating edge substituents by diarylamino ones results in an increase of ΔTPA values. The combination of large TPA cross sections and high emission quantum yields makes the title benzothiazole-based dyes attractive for applications involving two-photon excited fluorescence (TPEF).
SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR
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Page/Page column 10, (2009/01/20)
The present invention provides a method of inhibiting an androgen receptor by administering a compound of Formula I: or a compound of Formula II: wherein R1, R2, R3 and R8 are each independently hydrogen or C1-6 alkyl. R4 is absent or is hydrogen, C1-6 alkyl or C1-6 alkyl-OH. R5 is hydrogen, C1-6 alkyl or —NR6R7. R6 and R7 are each independently hydrogen or C1-6 alkyl, or are combined with the nitrogen to which they are attached to form a heterocycloalkyl having from 5 to 7 ring members. L is a linker of C1-6 alkylene, C2-6 alkenylene, C2-6 alkynylene or C3-6 cycloalkylene. The compounds of Formula I include the salts, hydrates and prodrugs thereof. Each R9 is H, C1-6 alkyl, —OH or —O—C1-6 alkyl. The compounds of Formulas I and II include the salts, hydrates and prodrugs thereof. By administering the compound of Formula I or II, the method inhibits the androgen receptor.
