104944-18-5

Basic information

• Product Name: H-D-Val-OtBu.HCl
• Synonyms: D-VALINE TERT-BUTYL ESTER HYDROCHLORIDE;H-D-Val-OtBu•(R)-tert-butyl 2-amino-3-methylbutanoate hydrochloride;D-Valine 1,1-dimethylethyl ester hydrochloride;tert-Butyl L-valinate HCl;D-Valine,1,1-diMethylethyl ester, hydrochloride (1:1);H-D-Val-OtBu;D-Valine tert-butyl ester, HCl
• CAS NO: 104944-18-5
• Molecular Formula: C₉H₁₉NO₂*ClH
• Molecular Weight: 209.7136
• Mol File: 104944-18-5.mol

Chemical Properties

• Melting Point: 144-146℃
• Appearance: /
• Storage Temp.: Store at 0°C
• CAS DataBase Reference: H-D-Val-OtBu.HCl(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-Val-OtBu.HCl(104944-18-5)
• EPA Substance Registry System: H-D-Val-OtBu.HCl(104944-18-5)

Safety Data

• Hazardous Substances Data: 104944-18-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
H-D-Val-OtBu.HCl is used as a protected form of D-Valine for the synthesis of pharmaceutical compounds. Its presence in the structure of Actinomycin D, an antitumor drug, highlights its potential use in the development of new cancer treatments.
Used in Cell Culture Applications:
H-D-Val-OtBu.HCl is used as a selective growth agent for epithelial cells in mammalian kidney cultures. Its inhibitory effects on contaminating fibroblasts make it a valuable tool for maintaining the purity of cell cultures.
Used in Peptide Synthesis:
H-D-Val-OtBu.HCl is used as a building block in the synthesis of peptides and proteins. Its protected form allows for the controlled addition of D-Valine residues during the peptide assembly process, enabling the production of specific bioactive peptides with desired properties.
Used in Research and Development:
H-D-Val-OtBu.HCl is used as a research compound for studying the effects of D-amino acids on various biological processes. Its unique properties and applications make it a valuable tool for understanding the role of D-amino acids in peptide and protein function.

InChI:InChI=1/C9H19NO2.ClH/c1-6(2)7(10)8(11)12-9(3,4)5;/h6-7H,10H2,1-5H3;1H/t7-;/m1./s1

Upstream product

• 640-68-6 D-Val-OH 
• 115-11-7 isobutene 

Downstream Products

• 104944-19-6 Z-S-Pro-R-Val-OtBu 
• 779341-90-1 (R)-2-(4-bromobenzenesulfonylamino)-3-methylbutyric acid tert-butyl ester 
• 873923-16-1 2-(4-chloro-3-nitro-benzenesulfonylamino)-3-methyl-butyric acid tert-butyl ester 
• 910630-90-9 (R)-3-Methyl-2-[(Z)-(7S,8R,9S)-7,8,9-tris-benzyloxy-9-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-non-5-enoylamino]-butyric acid tert-butyl ester 
• 960113-36-4 tert-butyl (R)-2-(4-(dimethylamino)phenylsulfonamido)-3-methylbutanoate 
• 193810-39-8 tert-butyl (R)-2-(4-nitrophenylsulfonamido)-3-methylbutanoate 
• 161315-62-4 N-[(4-methoxyphenyl)sulfonyl]-D-valine tert-butyl ester 
• 873923-18-3 2-[(biphenyl-4-sulfonyl)-pyridin-3-ylmethyl-amino]-3-methyl-butyric acid tert-butyl ester 
• 854371-76-9 D-2-[4'-(benzofuran-2-ylmethoxy)biphenyl-4-sulfonylamino]-3-methylbutyric acid tert-butyl ester 
• 854372-24-0 benzofuran-2-carboxylic acid 4'-(1-tert-butoxycarbonyl-2-methylpropylsulfamoyl)biphenyl-4-yl ester 
• 854372-23-9 tert-butyl N-[(4'-{[(3-methyl-1-benzofuran-2-yl)carbonyl]oxy}-1,1'-biphenyl-4-yl)sulfonyl]-D-valinate 

Relevant articles and documents

STUDIES ON AMINO ACIDS AND PEPTIDES X. HPLC-MEDIATED TEST OF 2,4-BIS(4-METHOXYPHENYL)-1,3,2,4-DITHIADIPHOSPHETANE 2,4-DISULFIDE (LAWESSONS'S REAGENT) AS A RACEMIZATIONFREE COUPLING REAGENT IN PEPTIDE SYNTHESIS

The easily available 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (Lawesson's Reagent), 1, has been tested as a coupling reagent for racemization in peptide synthesis.The assay procedure is separation of stereomeric products by HPLC.Z-S-Pro-S-Val-S-Pro-OtBu and Z-S-Leu-S-Phe-S-Val-OtBu have been used as test peptides in 2+1 segment couplings, and only a small amount of epimerization (0.5 and 0.1percent, respectively) has been observed.