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105596-63-2

105596-63-2

Identification

Synonyms:2-Methoxy-pyridine-4-carboxylicacid;2-methoxyisonicotinic acid;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H319 Causes serious eye irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2-Methoxyisonicotinic Acid
  • Packaging:1g
  • Price:$ 75
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:2-Methoxyisonicotinic Acid
  • Packaging:250mg
  • Price:$ 55
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Methoxyisonicotinic Acid >98.0%(GC)(T)
  • Packaging:1g
  • Price:$ 35
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:2-Methoxyisonicotinic Acid >98.0%(GC)(T)
  • Packaging:5g
  • Price:$ 104
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Methoxyisonicotinic acid
  • Packaging:100 g
  • Price:$ 344
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Methoxyisonicotinic acid
  • Packaging:25 g
  • Price:$ 135
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-Methoxypyridine-4-carboxylic acid 97%
  • Packaging:1g
  • Price:$ 62
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Methoxy-4-pyridinecarboxylic acid 98%
  • Packaging:25g
  • Price:$ 74
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Methoxy-4-pyridinecarboxylic acid 98%
  • Packaging:5g
  • Price:$ 19
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Methoxy-4-pyridinecarboxylic acid 98%
  • Packaging:100g
  • Price:$ 265
  • Delivery:In stock
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Relevant articles and documentsAll total 3 Articles be found

Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections

Tan, Liang,Tao, Yunliang,Wang, Ting,Zou, Feng,Zhang, Shuhua,Kou, Qunhuan,Niu, Ao,Chen, Qian,Chu, Wenjing,Chen, Xiaoyan,Wang, Haidong,Yang, Yushe

, p. 2669 - 2684 (2017)

Conjugating a siderophore to an antibiotic is a promising strategy to overcome the permeability-mediated resistance of Gram-negative pathogens. On the basis of the structure of BAL30072, novel pyridone-conjugated monosulfactams incorporating diverse substituents into the methylene linker between the 1,3-dihydroxypyridin-4(1H)-one and the aminothiazole oxime were designed and synthesized. Structure-activity relationship studies revealed that a variety of substituents were tolerated, with isopropyl (compound 12c) and methylthiomethyl (compound 16a) showing the best efficacy against multidrug-resistant (MDR) Gram-negative pathogens. In addition, compound 12c exhibits a good free fraction rate in an in vitro human plasma protein binding test, along with a low clearance and favorable plasma exposure in vivo. In a murine systemic infection model with MDR Klebsiella pneumoniae, compound 12c shows an ED50 of 10.20 mg/kg. Taken together, the results indicate that compound 12c is a promising drug candidate for the treatment of serious infections caused by MDR Gram-negative pathogens.

NEW 2-AMIDOTHIADIAZOLE DERIVATIVES

-

Page/Page column 64, (2010/04/30)

New 2-amidothiadiazole derivatives having the chemical structure of formula (I) or pharmaceutically acceptable salts or N-oxides thereof as agonists of S1P1 receptors.

Process route upstream and downstream products

Process route

2,6-dichloropyridine-4-carboxylic acid
5398-44-7

2,6-dichloropyridine-4-carboxylic acid

2-methoxy-isonicotinic acid
105596-63-2

2-methoxy-isonicotinic acid

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 120 - 130 °C
2: concentrated H2SO4
3: palladium; aqueous methanol. KOH / Hydrogenation
With potassium hydroxide; sulfuric acid; palladium;
Multi-step reaction with 2 steps
1: 120 - 130 °C
2: palladium; aqueous methanol. KOH / Hydrogenation
With potassium hydroxide; palladium;
2-chloro-6-methoxyisonicotinic acid methyl ester
42521-10-8

2-chloro-6-methoxyisonicotinic acid methyl ester

2-methoxy-isonicotinic acid
105596-63-2

2-methoxy-isonicotinic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: palladium/charcoal; aqueous methanol; potassium acetate / Hydrogenation
2: aqueous methanol. KOH
With methanol; potassium hydroxide; palladium on activated charcoal; potassium acetate;
2-chloro-6-methoxy-isonicotinic acid
15855-06-8

2-chloro-6-methoxy-isonicotinic acid

2-methoxy-isonicotinic acid
105596-63-2

2-methoxy-isonicotinic acid

Conditions
Conditions Yield
With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; at 20 ℃; under 155.149 Torr;
78%
With potassium hydroxide; palladium; Hydrogenation;
Multi-step reaction with 2 steps
1: concentrated H2SO4
2: palladium; aqueous methanol. KOH / Hydrogenation
With potassium hydroxide; sulfuric acid; palladium;
carbon dioxide
124-38-9,18923-20-1

carbon dioxide

C<sub>6</sub>H<sub>6</sub>FNO<sub>4</sub>S

C6H6FNO4S

2-methoxy-isonicotinic acid
105596-63-2

2-methoxy-isonicotinic acid

Conditions
Conditions Yield
With manganese; bis(triphenylphosphine)nickel(II) chloride; 2.9-dimethyl-1,10-phenanthroline; In N,N-dimethyl-formamide; at 20 ℃; for 20h; under 760.051 Torr; Schlenk technique; Inert atmosphere; Glovebox;
4-cyano-2-methoxypyridine
72716-86-0

4-cyano-2-methoxypyridine

2-methoxy-isonicotinic acid
105596-63-2

2-methoxy-isonicotinic acid

Conditions
Conditions Yield
With water; sodium hydroxide; In ethanol; for 1h; Reflux;
88%
2-methoxypyridin-4-ol
66080-45-3

2-methoxypyridin-4-ol

2-methoxy-isonicotinic acid
105596-63-2

2-methoxy-isonicotinic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: fluorosulfonyl fluoride; triethylamine / dichloromethane / 24 h / 20 °C / 760.05 Torr
2: bis(triphenylphosphine)nickel(II) chloride; 2.9-dimethyl-1,10-phenanthroline; manganese / N,N-dimethyl-formamide / 20 h / 20 °C / 760.05 Torr / Schlenk technique; Inert atmosphere; Glovebox
With manganese; bis(triphenylphosphine)nickel(II) chloride; fluorosulfonyl fluoride; 2.9-dimethyl-1,10-phenanthroline; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
2-chloro-4-pyridinenitrile
33252-30-1

2-chloro-4-pyridinenitrile

2-methoxy-isonicotinic acid
105596-63-2

2-methoxy-isonicotinic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 1,4-dioxane / 4 h / Reflux
2: sodium hydroxide; water / ethanol / 1 h / Reflux
With water; sodium hydroxide; In 1,4-dioxane; ethanol;
methyl 2-methoxyisonicotinate
26156-51-4

methyl 2-methoxyisonicotinate

2-methoxy-isonicotinic acid
105596-63-2

2-methoxy-isonicotinic acid

Conditions
Conditions Yield
With potassium hydroxide;
methyl 2,6-dichloroisonicotinate
42521-09-5

methyl 2,6-dichloroisonicotinate

2-methoxy-isonicotinic acid
105596-63-2

2-methoxy-isonicotinic acid

Conditions
Conditions Yield
Multi-step reaction with 3 steps
2: palladium/charcoal; aqueous methanol; potassium acetate / Hydrogenation
3: aqueous methanol. KOH
With methanol; potassium hydroxide; palladium on activated charcoal; potassium acetate;
Ethyl 6-chloro-2-methoxy-pyridine-4-carboxylate
106719-08-8

Ethyl 6-chloro-2-methoxy-pyridine-4-carboxylate

2-methoxy-isonicotinic acid
105596-63-2

2-methoxy-isonicotinic acid

Conditions
Conditions Yield
With potassium hydroxide; palladium; Hydrogenation;

Global suppliers and manufacturers

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  • Shaanxi BLOOM TECH Co.,Ltd
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  • Chemwill Asia Co., Ltd.
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  • Bluecrystal chem-union
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  • Win-Win chemical Co.Ltd
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  • GIHI CHEMICALS CO.,LIMITED
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  • Emails:info@gihichem.com
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