105596-63-2

Basic information

• Product Name: 2-Methoxy-4-pyridinecarboxylic acid
• Synonyms: 2-METHOXYISONICOTINIC ACID;2-METHOXYPYRIDINE-4-CARBOXYLIC ACID;2-METHOXY-4-PYRIDINECARBOXYLIC ACID;2-METHOXYISONICOTONIC ACID;4-Pyridinecarboxylicacid,2-methoxy-(9CI);4-METHOXY-4-PYRIDINECARBOXYLIC ACID;Zinc00336011;2-methoxy-4-picolinic acid
• CAS NO: 105596-63-2
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• Product Categories: CARBOXYLICACID;blocks;Carboxes;Pyridines;Pyridine
• Mol File: 105596-63-2.mol

Chemical Properties

• Melting Point: 197-200°C
• Boiling Point: 383 °C at 760 mmHg
• Flash Point: 185.4 °C
• Appearance: White to pale brown/Solid or Crystalline Powder
• Density: 1.284 g/cm³
• Vapor Pressure: 1.5E-06mmHg at 25°C
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.50±0.10(Predicted)
• CAS DataBase Reference: 2-Methoxy-4-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-4-pyridinecarboxylic acid(105596-63-2)
• EPA Substance Registry System: 2-Methoxy-4-pyridinecarboxylic acid(105596-63-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 105596-63-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-4-pyridinecarboxylic acid is used as a building block for the synthesis of various medications, particularly those with antiviral and antitumor properties. Its unique structure allows for the development of drugs that can target specific biological pathways, contributing to the treatment of viral infections and cancer.
Used in Organic Synthesis:
As a valuable intermediate, 2-Methoxy-4-pyridinecarboxylic acid is utilized in organic synthesis for the creation of a wide range of chemical compounds. Its versatile reactivity enables chemists to modify its structure to achieve desired properties in the final products.
Used in Research and Development:
2-Methoxy-4-pyridinecarboxylic acid is also used in research and development for studying its potential anti-inflammatory and antioxidant effects. This exploration can lead to the discovery of new therapeutic agents that can address inflammation and oxidative stress-related conditions.

InChI:InChI=1/C7H7NO3/c1-11-6-4-5(7(9)10)2-3-8-6/h2-4H,1H3,(H,9,10)/p-1

Upstream product

• 15855-06-8 2-chloro-6-methoxy-isonicotinic acid 
• 26156-51-4 methyl 2-methoxyisonicotinate 
• 106719-08-8 Ethyl 6-chloro-2-methoxy-pyridine-4-carboxylate 
• 42521-10-8 2-chloro-6-methoxyisonicotinic acid methyl ester 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 66080-45-3 2-methoxypyridin-4-ol 
• 124-38-9 carbon dioxide 
• 72716-86-0 4-cyano-2-methoxypyridine 
• 5398-44-7 2,6-dichloropyridine-4-carboxylic acid 
• 42521-09-5 methyl 2,6-dichloroisonicotinate 

Downstream Products

• 105596-61-0 ethyl 2-methoxy-pyridine-4-carboxylate 
• 89937-77-9 methyl 2-oxo-1,2-dihydropyridine-4-carboxylate 
• 19353-97-0 2-methoxy-isonicotinic acid hydrazide 
• 126798-21-8 2-methoxy-N-phenylisonicotinamide 
• 193538-79-3 2-methoxypyridine-4-carbonyl chloride 
• 1312559-09-3 (S)-2-methoxy-N-methyl-N-(4-(1-methyl-1H-pyrrole-2-carboxamido)-1-phenylbutan-2-yl)isonicotinamide 
• 355013-79-5 4-(chloromethyl)-2-methoxypyridine 
• 123148-66-3 2-methoxy-4-(hydroxymethyl)-pyridine 
• 120277-15-8 4-(bromomethyl)-2-methoxypyridine 
• 72716-87-1 2-methoxypyridine-4-carboxaldehyde 
• 764708-20-5 1-(2-methoxypyridin-4-yl)ethanone 

Relevant articles and documents

Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections

Conjugating a siderophore to an antibiotic is a promising strategy to overcome the permeability-mediated resistance of Gram-negative pathogens. On the basis of the structure of BAL30072, novel pyridone-conjugated monosulfactams incorporating diverse substituents into the methylene linker between the 1,3-dihydroxypyridin-4(1H)-one and the aminothiazole oxime were designed and synthesized. Structure-activity relationship studies revealed that a variety of substituents were tolerated, with isopropyl (compound 12c) and methylthiomethyl (compound 16a) showing the best efficacy against multidrug-resistant (MDR) Gram-negative pathogens. In addition, compound 12c exhibits a good free fraction rate in an in vitro human plasma protein binding test, along with a low clearance and favorable plasma exposure in vivo. In a murine systemic infection model with MDR Klebsiella pneumoniae, compound 12c shows an ED50 of 10.20 mg/kg. Taken together, the results indicate that compound 12c is a promising drug candidate for the treatment of serious infections caused by MDR Gram-negative pathogens.

Nickel-catalyzed carboxylation of aryl and heteroaryl fluorosulfates using carbon dioxide

The development of efficient and practical methods to construct carboxylic acids using CO2 as a C1 synthon is of great importance. Nickel-catalyzed carboxylation of aryl fluorosulfates and heteroaryl fluorosulfates with CO2 is described, affording arene carboxylic acids with good to excellent yields under mild conditions. In addition, a one-pot phenol fluorosulfation/carboxylation is developed.

NEW 2-AMIDOTHIADIAZOLE DERIVATIVES

New 2-amidothiadiazole derivatives having the chemical structure of formula (I) or pharmaceutically acceptable salts or N-oxides thereof as agonists of S1P1 receptors.