110723-51-8Relevant articles and documents
Preparation of active esters on solid support for aqueous-phase peptide couplings
Corbett, Andrew D.,Gleason, James L.
, p. 1369 - 1372 (2002)
TentaGel supported active esters analogous to those prepared from solution-phase reagents such as 1-hydroxybenzotriazole, N-hydroxysuccinimide, and pentafluorophenol were prepared and examined for their ability to effect aqueous-phase peptide couplings. HOBt esters showed high hydrolysis rates, relative to peptide coupling, while active esters derived from 4-hydroxy-2,3,5,6-tetrafluorobenzoic acid produced mainly dipeptide coupling products when treated with amino acids in water.
Amidation of aryl halides with isocyanides using a polymer-supported palladium-n-heterocyclic carbene complex as an efficient, phosphine-free and heterogeneous recyclable catalyst
Khairnar, Bhikan J.,Bhanage, Bhalchandra M.
supporting information, p. 1236 - 1242 (2014/05/06)
The amidation of aryl halides with alkyl/aryl isocyanides to give the corresponding amides using polymer-supported palladium-N-heterocyclic carbene complex (PS-Pd-NHC) as an efficient heterogeneous recyclable catalyst is described. The catalytic system was optimized with respect to various reaction parameters giving excellent yields of the desired products. The catalyst can be easily separated by a simple filtration process and recycled further for up to four consecutive recycle without any loss of activity and selectivity. The protocol is advantageous due to the ease in handling of the catalyst, simple workup procedure, phosphine-free, and effective catalyst recyclability. Georg Thieme Verlag Stuttgart New York.
Discovery of AMG 853, a CRTH2 and DP dual antagonist
Liu, Jiwen,Li, An-Rong,Wang, Yingcai,Johnson, Mike G.,Su, Yongli,Shen, Wang,Wang, Xuemei,Lively, Sarah,Brown, Matthew,Lai, Sujen,Gonzalez Lopez De Turiso, Felix,Xu, Qingge,Van Lengerich, Bettina,Schmitt, Mike,Fu, Zice,Sun, Ying,Lawlis, Shanna,Seitz, Lisa,Danao, Jay,Wait, Jill,Ye, Qiuping,Tang, Hua Lucy,Grillo, Mark,Collins, Tassie L.,Sullivan, Timothy J.,Medina, Julio C.
scheme or table, p. 326 - 330 (2011/07/09)
Prostaglandin D2 (PGD2) plays a key role in mediating allergic reactions seen in asthma, allergic rhinitis, and atopic dermatitis. PGD2 exerts its activity through two G protein-coupled receptors (GPCRs), prostanoid D rece
PHENYL ACETIC ACID DERIVATIVES AS INFLAMMATION MODULATORS
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Page/Page column 35, (2009/08/14)
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of p