1122-54-9

Basic information

• Product Name: 4-Acetylpyridine
• Synonyms: METHYL 4-PYRIDYL KETONE;4-ACETYLPYRIDINE;AKOS BBS-00003233;1-(4-pyridinyl)-ethanon;1-(4-Pyridinyl)ethanone;1-pyridin-4-yl-ethanone;4-acetyl-pyridin;4-Pyridyl methyl ketone
• CAS NO: 1122-54-9
• Molecular Formula: C₇H₇NO
• Molecular Weight: 121.14
• EINECS: 214-350-9
• Product Categories: ACETYLGROUP;Pyridine;Heterocyclic Compounds;CHIRAL CHEMICALS;Heterocycle-Pyridine series
• Mol File: 1122-54-9.mol
• Article Data: 98

Chemical Properties

• Melting Point: 13-16 °C(lit.)
• Boiling Point: 212 °C(lit.)
• Flash Point: >230 °F
• Appearance: brown-yellowish/Liquid
• Density: 1.095 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.17mmHg at 25°C
• Refractive Index: n20/D 1.529(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: Chloroform, Ethyl Acetate
• PKA: pK1: 3.505(+1) (25°C)
• Water Solubility: insoluble
• BRN: 107629
• CAS DataBase Reference: 4-Acetylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetylpyridine(1122-54-9)
• EPA Substance Registry System: 4-Acetylpyridine(1122-54-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36/38-22
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• RTECS: OB5426000
• F: 8
• TSCA: Yes
• Hazardous Substances Data: 1122-54-9(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow to brownish liquid

Uses

Different sources of media describe the Uses of 1122-54-9 differently. You can refer to the following data:
1. 4-Acetylpyridine is a acetylated pyridine used in the preparation of nitrogen containing bicyclic heterocycles and other organic compounds. 4-Acetylpyridine is also present in mainstream cigarette smo ke.
2. 4-acetylpyridine on reaction with - and 4-formylpyridine (H3FoPyS, H4FoPyS) yields semicarbazones. Reaction of acetylpyridine with thiophene-2-carboxaldehyde afforded the 2-chloro-6-ethoxy-4-β-(2-thienyl)acryloylpyridine, which was reacted with malononitrile in refluxing ethanol in the presence of piperidine as a catalyst to afford the cyanoaminopyrane derivative.

General Description

Dark amber liquid.

Air & Water Reactions

Soluble in water.

Reactivity Profile

4-Acetylpyridine is incompatible with strong oxidizing agents and strong reducing agents. . Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Fire Hazard

4-Acetylpyridine is probably combustible.

InChI:InChI=1/C7H7NO/c1-6(9)7-2-4-8-5-3-7/h2-5H,1H3

Upstream product

• 536-75-4 4-Ethylpyridine 
• 1570-45-2 isonicotinic acid ethylester 
• 141-78-6 ethyl acetate 
• 1194-99-6 4-acetylpyridine oxime 
• 530-40-5 N,N-diethylisonicotinamide 
• 917-54-4 methyllithium 
• 100-48-1 pyridine-4-carbonitrile 
• 917-64-6 methyl magnesium iodide 
• 504-24-5 4-aminopyridine 
• 431-03-8 dimethylglyoxal 
• 17755-30-5 (pyridin-4-yl)-α-methylstyrene 
• 887144-97-0 Togni's reagent 
• 872-85-5 pyridine-4-carbaldehyde 
• 34064-35-2 4-(oxiran-2-yl)pyridine 

Downstream Products

• 135450-67-8 4-acetyl-2-(ethoxycarbonyl)pyridine 
• 69267-29-4 <2,3-bis(4-pyridyl)-2,3-butanediol> 
• 10425-22-6 Benzil dicyanohydrin 
• 81390-24-1 2-(4-pyridyl)-2-hydroxy-1-phenyl-1-propanone 
• 78061-50-4 1-[1-Benzoyl-2-(1H-indol-3-yl)-1,2-dihydro-pyridin-4-yl]-ethanone 
• 123005-19-6 1-(2-isopropylpyridin-4-yl)ethanone 
• 19490-94-9 1-phenyl-1-(pyridin-4-yl)ethan-1-ol 
• 107027-42-9 8-Methyl-2-pyridin-4-yl-quinoline-4-carboxylic acid 
• 83393-57-1 3-Hydroxy-1-methyl-3-(2-oxo-2-pyridin-4-yl-ethyl)-1,3-dihydro-indol-2-one 
• 40899-89-6 1-(1-benzenesulfonyl indole-2-yl)-1-(4-pyridyl)-ethanol 
• 83001-16-5 1-(2-Cyclohexyl-pyridin-4-yl)-ethanone 
• 83001-37-0 1-(3-Cyclohexyl-pyridin-4-yl)-ethanone 
• 106807-83-4 (Z)-4-Benzenesulfonyl-3-methylsulfanyl-1-pyridin-4-yl-but-2-en-1-one 
• 107456-71-3 1-Phenyl-2-(4-pyridyl)-1,2-propanediol 

Related news

Crystal structures and IR, NMR and UV spectra of 4-formyl- and 4-Acetylpyridine (cas 1122-54-9) N(4)-methyl- and N(4)-ethylthiosemicarbazones10/01/2019

4-Formyl- and 4-acetylpyridine N(4)-methyl- and N(4)-ethylthiosemicarbazone have been prepared, their structures solved and IR, NMR and UV spectra recorded. Intramolecular and intermolecular hydrogen bonding are both present, but the mode of the intermolecular interaction differs in the four com...detailed

Solvent-controlled construction of manganese(II) complexes with 4-Acetylpyridine (cas 1122-54-9) nicotinoylhydrazone ligand09/27/2019

Three new manganese(II) complexes, namely [Mn(NCS)2(L)2(CH3OH)2]·2CH3OH (1), [Mn(NCS)2(L)2(C2H5OH)2]·2C2H5OH (2) and [Mn(NCS)2(μ-L)2]n (3) (L = 4-acetylpyridine nicotinoylhydrazone) have been synthesized and characterized by elemental analysis, IR spectra, single-crystal and powder X-ray diff...detailed

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