1130-80-9

Basic information

• Product Name: Naphthalene, 2-Methoxy-1-Methyl-
• Synonyms: Naphthalene, 2-Methoxy-1-Methyl-;2-methoxy-1-methylNaphthalene
• CAS NO: 1130-80-9
• Molecular Formula: C₁₂H₁₂O
• Molecular Weight: 172.22308
• Mol File: 1130-80-9.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Naphthalene, 2-Methoxy-1-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Naphthalene, 2-Methoxy-1-Methyl-(1130-80-9)
• EPA Substance Registry System: Naphthalene, 2-Methoxy-1-Methyl-(1130-80-9)

Safety Data

• Hazardous Substances Data: 1130-80-9(Hazardous Substances Data)

Usage

Description

Naphthalene, 2-methoxy-1-methyl-, also known as 1-methyl-2-methoxynaphthalene, is a chemical compound with the molecular formula C11H10O. It is a white, crystalline solid that serves as a versatile chemical intermediate in the synthesis of various substances, including pharmaceuticals, dyes, and insecticides. Naphthalene, 2-methoxy-1-methylis also utilized as a solvent and a starting material for the production of other compounds. Due to its potential harmful effects if ingested, inhaled, or comes into contact with the skin, it is crucial to handle this chemical with care and follow proper safety protocols, including the use of personal protective equipment.

Uses

Used in Pharmaceutical Industry:
Naphthalene, 2-methoxy-1-methylis used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Dye Industry:
In the dye industry, Naphthalene, 2-methoxy-1-methylis utilized as a starting material for the production of different types of dyes. Its chemical properties enable the creation of dyes with specific color characteristics and stability.
Used in Insecticide Production:
Naphthalene, 2-methoxy-1-methylis employed as a chemical intermediate in the manufacturing of insecticides. Its ability to be incorporated into various chemical structures contributes to the development of effective insect control agents.
Used as a Solvent:
Naphthalene, 2-methoxy-1-methylis also used as a solvent in various chemical processes. Its solubility properties make it suitable for dissolving other substances, facilitating reactions, and improving the efficiency of chemical processes.
Used in Synthesis of Other Compounds:
Naphthalene, 2-methoxy-1-methylserves as a starting material for the synthesis of a wide range of compounds. Its versatility in chemical reactions allows for the creation of new substances with diverse applications across various industries.

Upstream product

• 67367-39-9 1-chloromethyl-2-methoxynaphthalene 
• 3401-47-6 1-bromo-2-methoxynaphthalene 
• 74-88-4 methyl iodide 
• 135-19-3 β-naphthol 
• 92643-16-8 6-Bromo-1-(chloromethyl)-2-methoxynaphthalene 
• 1076-26-2 1-methyl-2-naphthol 
• 77-78-1 dimethyl sulfate 
• 5392-12-1 2-methoxy-1-naphthaldehyde 
• 495-69-2 Hippuric Acid 
• 67-56-1 methanol 
• 16000-39-8 1-cyano-2-methoxynaphthalene 
• 75-16-1 methylmagnesium bromide 
• 52805-47-7 1-cyano-2-hydroxynaphthalene 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 90-12-0 1-Methylnaphthalene 
• 112212-88-1 2-acetyl-cis-cinnamic acid methyl ester 
• 17324-10-6 1,6-Dimethyl-[2]naphthol 
• 866996-60-3 2-(6-hydroxy-5-methyl-[2]naphthylmethyl)-benzoic acid 
• 101736-52-1 (6-hydroxy-5-methyl-[2]naphthyl)-phenyl ketone 
• 1076-26-2 1-methyl-2-naphthol 
• 17580-39-1 1-Methyl-2-methoxy-6-chlormethyl-naphthalin 
• 4024-14-0 1-methyl-2-tetralone 
• 1758-21-0 6-methoxy-5-methyltetralene 

Relevant articles and documents

Selectivity engineering of solid base catalyzed O-methylation of 2-naphthol with dimethyl carbonate to 2-methoxynaphthalene

2-Methoxynaphthalene is an important intermediate used in the production of naproxen which is widely used as a non-steroidal, anti-inflammatory, analgesic and antipyretic drug. In the current work, catalytic methylation of 2-naphthol was studied by using dimethyl carbonate as a greener agent vis-à-vis methyl halides and dimethyl sulfate. Catalysts based on calcined-hydrotalcite (CHT) supported on hexagonal mesoporous silica (HMS) were synthesized. Effect of CHT loading on HMS was systematically studied including full characterization. The activity and selectivity of CHT/HMS was examined by studying the effects of different operating parameters to deduce mechanism and kinetics. Conversion of 2-naphthol at 463 K and autogenous pressure was 92% with 90% selectivity toward 2-methoxynaphthalene on 20% (w/w) CHT/HMS. The catalyst was easily recovered and reused without any significant loss in activity. A kinetic model was developed. It follows zero order kinetics based on Langmuir-Hinshelwood-Hougen-Watson mechanism with strong adsorption of reactants. The apparent activation energy is 32.3 kcal/mol.

Lewis Acid-Mediated Cyanation of Phenols Using N-Cyano-N-phenyl-p-toluenesulfonamide

Lewis acid-mediated cyanation of phenol derivatives with N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) has been developed. The reaction proceeded efficiently with high regioselectivity to produce aromatic nitriles in moderate to excellent yields, which provides a direct and practical access to valuable products. (Figure presented.).

Lewis Acid Assisted Nickel-Catalyzed Cross-Coupling of Aryl Methyl Ethers by C-O Bond-Cleaving Alkylation: Prevention of Undesired β-Hydride Elimination

In the presence of trialkylaluminum reagents, diverse aryl methyl ethers can be transformed into valuable products by C-O bond-cleaving alkylation, for the first time without the limiting β-hydride elimination. This new nickel-catalyzed dealkoxylative alkylation method enables powerful orthogonal synthetic strategies for the transformation of a variety of naturally occurring and easily accessible anisole derivatives. The directing and/or activating properties of aromatic methoxy groups are utilized first, before they are replaced by alkyl chains in a subsequent coupling process.