114084-54-7Relevant articles and documents
Method for synthesizing N-alkyl-N-aryl (methyl) acrylamide double-tail hydrophobic monomer
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Paragraph 0026; 0027, (2019/10/01)
The invention discloses a method for synthesizing an N-alkyl-N-aryl (methyl) acrylamide double-tail hydrophobic monomer. The method comprises the following steps: (1) putting alkylamine into a methanol solution with aromatic aldehyde, increasing the temperature till backflow, and performing a reaction over night; reducing the temperature of the mixed liquid to 5 DEG C or lower, adding a small amount of sodium borohydride for multiple times, removing an ice water bath, continuously performing a reaction for 30-120 minutes, and performing a backflow reaction for 3-6 hours; adding a certain amount of water to quench the reaction, drying an organic phase, and performing rotational evaporation so as to remove a solvent so as to obtain N-aryl-N-alkylamine; and (2) dissolving the N-aryl-N-alkylamine by using dichloromethane, adding a NaOH solution, slowly dropping a dichloromethane solution of (methyl) acryloyl chloride under a stirring condition of the ice water bath, performing heating to the room temperature, continuously performing a reaction for 2-12 hours, washing an organic layer till neutral by using distilled water, and further performing drying and rotational evaporation, so asto obtain N-alkyl-N-aryl (methyl) acrylamide. The method is gentle in reaction condition, short in reaction time, high in yield and applicable to large-scale industrial application.
Convenient synthesis of 6,6-bicyclic malonamides: A new class of conformationally preorganized ligands for f-block ion binding
Parks, Bevin W.,Gilbertson, Robert D.,Domaille, Dylan W.,Hutchison, James E.
, p. 9622 - 9627 (2007/10/03)
A general synthetic approach was developed for the preparation of a series of 6,6-bicyclic malonamides, a class of ligands that provide a preorganized binding site for f-block ions (particularly trivalent lanthanides). The approach described is convenient to introduce a variety of functional groups at the amide nitrogens to tune the properties of the ligand without altering the preorganized binding. Each of the ten derivatives (that represent a range of functionality, including R = alkyl, hydroxy, phenyl, ester, perfluorocarbon) reported here derives from a single, readily prepared dialdehyde intermediate. This intermediate is converted to the final products via reductive amination with an appropriately functionalized benzylamine, followed by hydrogenolysis and lactam formation. Because derivatization occurs late in the synthesis, the approach is general, requiring only modification of the purification procedures for each new derivative. To aid in the purification of the bicyclic malonamides, we report a novel complexation-based purification method that takes advantage of the high affinity of the ligand for f-block metals.
Synthesis, characterization, and reverse-micellar studies of some N-substituted derivatives of 6-amino-6-deoxy-1,2-O-isopropylidene-D-glucose
Sharma,Singh
, p. 43 - 49 (2007/10/02)
Dry heating of N-substituted hexadecylamines with 5,6-anhydro- 1,2-O-isopropylidene-α-D-glucofuranose afforded glucose-based nonionic surfactants having a tertiary amino group linked to C-6 of the glucose moiety. These surfactants were tested for the solu
