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118289-16-0

118289-16-0

118289-16-0

Identification

Synonyms:(2-Bromopyridin-4-yl)methanol;2-Bromo-4-(hydroxymethyl)pyridine;2-Bromo-4-pyridinemethanol;

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Chemical Properties

  • Melting Point: 58-61 °C

  • Boiling Point: 316.6 °C at 760 mmHg

  • Flash Point:145.3 °C

  • Density: 1.668 g/cm3

  • Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature

  • Vapor Pressure: 0.000171mmHg at 25°C

  • Refractive Index: 1.598

  • PKA: 13.06±0.10(Predicted)

  • BRN: 4244047

  • PSA: 33.12000

  • LogP: 1.33640

Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi,Xn

  • Signal Word:Danger

  • Hazard Statement:H302 Harmful if swallowedH315 Causes skin irritation H318 Causes serious eye damage H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price view more

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:2-Bromo-4-hydroxymethylpyridine
  • Packaging:500mg
  • Price:$ 50
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:2-Bromo-4-hydroxymethylpyridine
  • Packaging:10g
  • Price:$ 455
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Bromo-4-(hydroxymethyl)pyridine
  • Packaging:25 g
  • Price:$ 205
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:2-Bromo-4-(hydroxymethyl)pyridine
  • Packaging:10 g
  • Price:$ 114
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-Bromo-4-hydroxymethylpyridine 96%
  • Packaging:1g
  • Price:$ 40.9
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Bromo-4-(hydroxymethyl)pyridine 97%
  • Packaging:1g
  • Price:$ 10
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Bromo-4-(hydroxymethyl)pyridine 97%
  • Packaging:5g
  • Price:$ 39
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:2-Bromo-4-(hydroxymethyl)pyridine 97%
  • Packaging:25g
  • Price:$ 187
  • Delivery:In stock
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  • Manufacture/Brand:Labseeker
  • Product Description:2-Bromopyridine-4-methanol 95
  • Packaging:50g
  • Price:$ 415
  • Delivery:In stock
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  • Manufacture/Brand:Heterocyclics
  • Product Description:(2-Bromopyridin-4-yl)methanol 96%
  • Packaging:25g
  • Price:$ 115
  • Delivery:In stock
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Relevant articles and documentsAll total 11 Articles be found

LOX ENZYME INHIBITING METHODS AND COMPOSITIONS

-

Paragraph 251-253, (2021/10/30)

This invention relates to compounds, pharmaceutical compositions and their use for treating fibrotic disorders, proliferative disorders, cardiovascular diseases, acute and chronic inflammatory disorders, primary and metastatic cancer, pulmonary conditions, ocular diseases, or neurological and neuropsychiatric conditions. One particular aspect of the inventions relates to inhibitors of the family of lysyl oxidase enzymes and their use as therapeutics for fibrotic disorders.

TYK2 INHIBITORS AND USES THEREOF

-

Paragraph 00983; 00984, (2018/04/27)

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES

-

Page/Page column 100-101, (2012/06/30)

Provided are compounds of Formula (I): and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

Process route upstream and downstream products

Process route

2-bromoisonicotinic acid
66572-56-3

2-bromoisonicotinic acid

(2-bromopyridin-4-yl)methanol
118289-16-0

(2-bromopyridin-4-yl)methanol

Conditions
Conditions Yield
With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 20 ℃; for 3h;
75.21%
With lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine; Yield given. Multistep reaction; 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min;
Multi-step reaction with 2 steps
1: ethyl acetate; diethyl ether
2: LAH / tetrahydrofuran / 1 h / Ambient temperature
With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; ethyl acetate;
2-bromoisonicotinic acid; With triethylamine; isobutyl chloroformate; In tetrahydrofuran; at -70 - -10 ℃; for 1h;
With lithium aluminium tetrahydride; In tetrahydrofuran; acetic acid; at -70 - 20 ℃;
2-bromoisonicotinic acid; With borane-THF; In tetrahydrofuran; at 20 ℃;
With sodium hydroxide; In tetrahydrofuran; water; for 2h;
2-bromopyridine-4-carboxaldehyde
118289-17-1

2-bromopyridine-4-carboxaldehyde

(2-bromopyridin-4-yl)methanol
118289-16-0

(2-bromopyridin-4-yl)methanol

Conditions
Conditions Yield
With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h; Inert atmosphere;
90%
With sodium tetrahydroborate; In methanol; at 0 - 25 ℃; Inert atmosphere;
methyl 2-bromoisonicotinate
26156-48-9

methyl 2-bromoisonicotinate

(2-bromopyridin-4-yl)methanol
118289-16-0

(2-bromopyridin-4-yl)methanol

Conditions
Conditions Yield
With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Ambient temperature;
With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 0.5h; Inert atmosphere;
methanol
67-56-1

methanol

N-methoxy-2-methylpyridinium methosulphate
55369-05-6

N-methoxy-2-methylpyridinium methosulphate

2-bromo-6-(hydroxymethyl)pyridine
33674-96-3

2-bromo-6-(hydroxymethyl)pyridine

(2-bromopyridin-4-yl)methanol
118289-16-0

(2-bromopyridin-4-yl)methanol

Conditions
Conditions Yield
With fac-tris[2-phenylpyridinato-C2,N]iridium(III); sodium hydrogencarbonate; In acetonitrile; for 2h; Overall yield = 62 percent; Irradiation;
2-Amino-4-methylpyridine
695-34-1

2-Amino-4-methylpyridine

(2-bromopyridin-4-yl)methanol
118289-16-0

(2-bromopyridin-4-yl)methanol

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 87 percent / NaNO2, Br2, 48percent HBr / 5 °C
2: 48 percent / KMnO4 / H2O / Heating
3: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min
With potassium permanganate; lithium aluminium tetrahydride; hydrogen bromide; bromine; chloroformic acid ethyl ester; triethylamine; sodium nitrite; In water;
2-Bromo-4-picoline
4926-28-7

2-Bromo-4-picoline

(2-bromopyridin-4-yl)methanol
118289-16-0

(2-bromopyridin-4-yl)methanol

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 48 percent / KMnO4 / H2O / Heating
2: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min
With potassium permanganate; lithium aluminium tetrahydride; chloroformic acid ethyl ester; triethylamine; In water;
(2-bromopyridin-4-yl)methanol
118289-16-0

(2-bromopyridin-4-yl)methanol

Conditions
Conditions Yield
88%
87%
2-(trifluoromethyl)phenylboronic acid
1423-27-4

2-(trifluoromethyl)phenylboronic acid

(2-bromopyridin-4-yl)methanol
118289-16-0

(2-bromopyridin-4-yl)methanol

{2-[2-(trifluoromethyl)phenyl]pyridin-4-yl}methanol
1261819-36-6

{2-[2-(trifluoromethyl)phenyl]pyridin-4-yl}methanol

Conditions
Conditions Yield
With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; toluene; at 80 ℃; for 5h; Inert atmosphere;
85%
tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate
1252762-31-4

tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate

(2-bromopyridin-4-yl)methanol
118289-16-0

(2-bromopyridin-4-yl)methanol

tert-butyl (R)-4-(3-((2-bromopyridin-4-yl)methoxy)-4-chlorophenyl)-2-oxopyrrolidine-1-carboxylate

tert-butyl (R)-4-(3-((2-bromopyridin-4-yl)methoxy)-4-chlorophenyl)-2-oxopyrrolidine-1-carboxylate

Conditions
Conditions Yield
tert-butyl (R)-4-(4-chloro-3-hydroxyphenyl)-2-oxopyrrolidine-1-carboxylate; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 1h;
(2-bromopyridin-4-yl)methanol; In tetrahydrofuran; at 0 - 20 ℃; for 14h;
84.1%
(2-bromopyridin-4-yl)methanol
118289-16-0

(2-bromopyridin-4-yl)methanol

2,4-difluorophenylboronic acid
144025-03-6

2,4-difluorophenylboronic acid

(2-(2,4-difluorophenyl)pyridin-4-yl)methanol

(2-(2,4-difluorophenyl)pyridin-4-yl)methanol

Conditions
Conditions Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In ethanol; water; toluene; at 80 ℃; for 1.33333h; Inert atmosphere;
93%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In toluene; for 12h; Reflux;

118289-16-0 Upstream products

118289-16-0 Downstream products

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