118289-16-0

Basic information

• Product Name: 2-Bromopyridine-4-methanol
• Synonyms: 2-BROMO-4-(HYDROXYMETHYL)PYRIDINE;2-BROMO-4-PYRIDINE METHANOL;(2-BROMO-PYRIDIN-4-YL)-METHANOL;2-BROMOPYRIDINE-4-METHANOL;RARECHEM AL BD 1524;2-Bromopyridine-4-methanol ,96%;Bromopyridine-4-Methanol;4-Pyridinemethanol, 2-bromo-
• CAS NO: 118289-16-0
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.02
• EINECS: -0
• Product Categories: Hydroxymethyl's;Pyridines;Pyridine;Building Blocks;NULL;Heterocycle-Pyridine series
• Mol File: 118289-16-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 58-61°C
• Boiling Point: 316.6 °C at 760 mmHg
• Flash Point: 145.3 °C
• Appearance: /
• Density: 1.668 g/cm³
• Vapor Pressure: 0.000171mmHg at 25°C
• Refractive Index: 1.598
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 13.06±0.10(Predicted)
• BRN: 4244047
• CAS DataBase Reference: 2-Bromopyridine-4-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromopyridine-4-methanol(118289-16-0)
• EPA Substance Registry System: 2-Bromopyridine-4-methanol(118289-16-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37-22
• WGK Germany: 1
• HazardClass: IRRITANT
• Hazardous Substances Data: 118289-16-0(Hazardous Substances Data)

Usage

Chemical Properties

White to brown powder

Uses

2-Bromo-4-hydroxymethylpyridine is used to synthesize aza- and diazabiphenyl analogs of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824). It is also used to N3/8-disubstituted 3,8-diazabicyclo[3.2.1]octane analogues of 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl-piperazine with antiproliferative properties.

InChI:InChI=1/C6H6BrNO/c7-6-3-5(4-9)1-2-8-6/h1-3,9H,4H2

Upstream product

• 66572-56-3 2-bromoisonicotinic acid 
• 67-56-1 methanol 
• 55369-05-6 N-methoxy-2-methylpyridinium methosulphate 
• 118289-17-1 2-bromopyridine-4-carboxaldehyde 
• 4926-28-7 2-Bromo-4-picoline 
• 695-34-1 2-Amino-4-methylpyridine 
• 26156-48-9 methyl 2-bromoisonicotinate 

Downstream Products

• 1030829-16-3 (2-phenoxypyridin-4-yl)methanol 
• 1289387-96-7 C₇H₈BrNO 
• 864460-68-4 2-bromo-4-(chloromethyl)pyridine 
• 4634-12-2 4-(hydroxymethyl)-2-phenylpyridine 
• 83004-14-2 2-bromo-4-bromomethyl pyridine 

Relevant articles and documents

LOX ENZYME INHIBITING METHODS AND COMPOSITIONS

This invention relates to compounds, pharmaceutical compositions and their use for treating fibrotic disorders, proliferative disorders, cardiovascular diseases, acute and chronic inflammatory disorders, primary and metastatic cancer, pulmonary conditions, ocular diseases, or neurological and neuropsychiatric conditions. One particular aspect of the inventions relates to inhibitors of the family of lysyl oxidase enzymes and their use as therapeutics for fibrotic disorders.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES

Provided are compounds of Formula (I): and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.