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119-24-4

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  • Biggest manufacturer of PTEROIC ACID,higher purity, lower price, sample available from gihichem

    Cas No: 119-24-4

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119-24-4 Usage

Uses

Different sources of media describe the Uses of 119-24-4 differently. You can refer to the following data:
1. Pteroic Acid is a constituent as well as a degradation product of Folid Acid (F680300) formed via anzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutama te synthetase.
2. Pteroic Acid (Methotrexate EP Impurity D N-Desmethyl Impurity) is a constituent as well as a degradation product of Folic Acid (F680300) formed via enzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutamate synthetase.

General Description

Folic Acid Impurity D is an impurity of the water-soluble B-vitamin, folic acid. Folic Acid is generally used in the treatment of certain types of anemia.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Enzyme inhibitor

This metabolite (FWfree-acid = 312.29 g/mol; CAS 119-24-4), also known as 4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid, is a structural component of folates. Pteroic acid is a growth factor for a number of Enterococci. Pteroic acid is a yellow powder that is slightly soluble in aqueous NaOH. The lmax values in 0.1 M NaOH are 255, 275, and 365 nm (e = 26300, 23400, and 8900 M–1cm–1, respectively). Target(s): arylamine N-acetyltransferase; dihydrofolate reductase; dihydrofolate synthetase, weakly inhibited; dihydropteroate synthase; glutamate carboxypeptidase; and xanthine oxidase.

Purification Methods

Crystallise it from dilute HCl. Dry it in vacuo. Hygroscopic IRRITANT. [Nair et al. J Org Chem 46 3152 1981, Beilstein 26 III/IV 3942.]

Check Digit Verification of cas no

The CAS Registry Mumber 119-24-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 9 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 119-24:
(5*1)+(4*1)+(3*9)+(2*2)+(1*4)=44
44 % 10 = 4
So 119-24-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H12N6O3/c15-14-19-11-10(12(21)20-14)18-9(6-17-11)5-16-8-3-1-7(2-4-8)13(22)23/h1-4,6,16H,5H2,(H,22,23)(H3,15,17,19,20,21)

119-24-4 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0001243)  Folic acid impurity D  European Pharmacopoeia (EP) Reference Standard

  • 119-24-4

  • Y0001243

  • 1,880.19CNY

  • Detail
  • Aldrich

  • (P1781)  Pteroicacid  ≥93%

  • 119-24-4

  • P1781-25MG

  • 741.78CNY

  • Detail
  • Aldrich

  • (P1781)  Pteroicacid  ≥93%

  • 119-24-4

  • P1781-50MG

  • 1,289.34CNY

  • Detail
  • Aldrich

  • (P1781)  Pteroicacid  ≥93%

  • 119-24-4

  • P1781-100MG

  • 2,237.04CNY

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119-24-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid

1.2 Other means of identification

Product number -
Other names Pteroic Acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:119-24-4 SDS

119-24-4Related news

Determination of PTEROIC ACID (cas 119-24-4) by high-performance thin-layer chromatography: Contribution to the investigation of 7,8-dihydropteroate synthase09/03/2019

A TLC method was developed that allows the evaluation of the 7,8-dihydropteroate synthase reaction via determination of the stable pteroic acid (PtA), obtained by chemical oxidation of the enzymatic product dihydropteroic acid (H2PtA). Using amino-bonded HPTLC plates and solution of 52% acetonit...detailed

Preparation and purification of PTEROIC ACID (cas 119-24-4) from folic acid09/02/2019

Crude pteroic acid, obtained by microbiological degradation of folic acid, has been purified by column chromatography on cellulose CF11, eluting with 0.1 M glycine buffer of pH 10.0, containing 0.15% w/v ascorbic acid and saturated with isoamyl alcohol.detailed

[92] Preparation and purification of PTEROIC ACID (cas 119-24-4) from pteroylglutamic acid (folic acid)09/01/2019

Publisher SummaryThis chapter describes the preparation and purification of pteroic acid from pteroylglutamic acid (folic acid). Pteroic acid can be prepared conveniently, by the removal of glutamic acid, from commercially available pteroyiglutamic acid, using a pteroylglutamic acid-degrading ps...detailed

Pharmaceutical NanotechnologyEnhanced cellular delivery of idarubicin by surface modification of propyl starch nanoparticles employing PTEROIC ACID (cas 119-24-4) conjugated polyvinyl alcohol08/30/2019

Enhanced intracellular internalization of the anti-cancer active idarubicin (IDA) was achieved through appropriate surface modification of IDA loaded propyl starch nanoparticles. This was conducted by synthesizing pteroic acid modified polyvinyl alcohol (ptPVA) and employing this stabilizer for ...detailed

119-24-4Relevant articles and documents

-

Hultquist et al.

, p. 23 (1948)

-

A step-wise synthetic approach is necessary to access γ-conjugates of folate: Folate-conjugated prodigiosenes

Figliola, Carlotta,Marchal, Estelle,Groves, Brandon R.,Thompson, Alison

, p. 14078 - 14092 (2019/05/21)

Despite the vast literature that describes reacting folic acid with a pharmacophore, this route is ineffective in providing the correct regioisomer of the resulting conjugate. We herein present a step-wise route to the preparation of nine folate conjugate

Site-specific folate conjugation to a cytotoxic protein

Smith, Bryan D.,Higgin, Joshua J.,Raines, Ronald T.

experimental part, p. 5029 - 5032 (2011/10/09)

Conjugation to folic acid is known to enhance the uptake of molecules by human cells that over-produce folate receptors. Variants of bovine pancreatic ribonuclease (RNase A) that have attenuated affinity for the endogenous ribonuclease inhibitor protein (

POSITRON EMISSION TOMOGRAPHY IMAGING METHOD

-

Page/Page column 30-31, (2008/12/08)

Described herein are compositions and methods for diagnosing and/or monitoring pathogenic disease states using positron emission tomography, wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. Also described herein are 18F conjugates of vitamins and vitamin receptor- binding analogs and derivatives.

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