120-03-6Relevant articles and documents
Sulfonic-acid-functionalized activated carbon made from tea leaves as green catalyst for synthesis of 2-substituted benzimidazole and benzothiazole
Goswami, Mridusmita,Dutta, Mintu Maan,Phukan, Prodeep
, p. 1597 - 1615 (2018)
Abstract: A simple and efficient procedure for synthesis of 2-substituted benzimidazole and benzothiazole has been developed by using sulfonic-acid-functionalized activated carbon as heterogeneous catalyst. The activated material was prepared from matured tea leaf in presence of phosphoric acid as activating agent. The final catalyst was prepared by anchoring –SO3H group on the surface of the activated carbon. The catalyst could be easily recovered and reused for more than three catalytic cycles without significant loss in catalytic activity. The catalytic performance of the catalyst was found to be superior to that of a similar catalyst prepared from montmorillonite K10. Graphical Abstract: [Figure not available: see fulltext.].
New one-pot procedure for the synthesis of 2-substituted benzimidazoles
Sharghi, Hashem,Asemani, Omid,Khalifeh, Reza
, p. 1128 - 1136 (2008)
A highly selective synthesis of 2-substituted benzimidazole derivatives from the reaction of o-phenylendiamine derivatives and aromatic aldehydes in the presence of an organic salt, NH4OAc, in absolute ethanol is presented. The products were obtained by evaporating the solvent followed by a simple recrystallization with excellent yields. Copyright Taylor & Francis Group, LLC.
Synthesis of 2-Substituted benzimidazoles catalyzed by FeCl 3/Al2O3 under ultrasonic irradiation
Chen, Guo-Feng,Dong, Xiao-Yun,Meng, Fan-Zhu,Chen, Bao-Hua,Li, Ji-Tai,Wang, Shu-Xiang,Bai, Guo-Yi
, p. 464 - 469 (2011)
2-substituted benzimidazoles have been synthesized in a single pot from aromatic aldehydes and ophenylenediamine catalyzed by FeCl3/Al 2O3 in DMF under ultrasonic irradiation and afforded good yields in a short period of t
Enhanced Catalytic Properties of Molybdenum Promoted Mesoporous Cobalt Oxide: Structure-Surface-Dependent Activity for Selective Synthesis of 2-Substituted Benzimidazoles
Weerakkody, Chandima,Rathnayake, Dinithi,He, Junkai,Dutta, Biswanath,Kerns, Peter,Achola, Laura,Suib, Steven L.
, p. 528 - 537 (2019)
High-valent molybdenum ions were substituted into the cobalt oxide lattice through a one step, sol-gel method and investigated for selective synthesis of 2-substituted benzimidazoles. Catalyst synthesis involves surfactant assisted soft templating inverse micelle method, which forms mesopores by interconnected intraparticle voids. Substitutional doping of Mo6+ resulted in materials with modified structural, morphological, surface, and redox properties. The catalytic activity increased with Mo concentration until an optimum amount (3 % Mo incorporation). Modified material shows lattice expansion, increased surface oxygen vacancies, and high surface area, which are responsible for the higher catalytic activity in selective benzimidazole synthesis reaction. A strong correlation between surface properties of the catalyst and the product selectivity was observed and plausible mechanistic and kinetic data are proposed and collected, respectively.
Reusable nano-zirconia-catalyzed synthesis of benzimidazoles and their antibacterial and antifungal activities
Ahmad, Naushad,Ahmed, Faheem,Albalawi, Fadwa,Alomar, Suliman Yousef,Basaveswara Rao, M. V.,Cheedarala, Ravi Kumar,Naidu, Tentu Manohra,Rao, Nalla Krishna,Rao, Tentu Nageswara,Reddy, G. Rajasekhar
, (2021)
In this article, a zirconia-based nano-catalyst (Nano-ZrO2 ), with intermolecular C-N bond formation for the synthesis of various benzimidazole-fused heterocycles in a concise method is reported. The robustness of this reaction is demonstrated
A novel ionic liquid based on imidazolium cation as an efficient and reusable catalyst for the one-pot synthesis of benzoxazoles, benzthiazoles, benzimidazoles and 2-arylsubstituted benzimidazoles
Hasanpour, Maede,Eshghi, Hossein,Bakavoli, Mehdi,Mirzaeia, Mahdi
, p. 412 - 419 (2015)
A novel dicationic ionic liquid based on imidazolium cation is designed, synthesized and successfully used as catalyst for the one-pot synthesis of benzoxazoles, benzthiazoles, benzimidazoles and 2-arylsubstituted benzimidazoles. The remarkable feature of this new catalyst is its ethyleneoxy bridge which participates in dissolving organic compound in ionic liquid. The application of this ionic liquid is studied in a new one-pot method for synthesis of heterocyclic compounds under solvent-free conditions. Simple and convenient procedure, high conversion, reusability of catalyst, easy purification and shorter reaction time are the advantageous features of this method.
Cobalt ferrite magnetic nanoparticles as highly efficient catalyst for the mechanochemical synthesis of 2-aryl benzimidazoles
Borade, Ravikumar M.,Jadhav, K. M.,Kale, Swati B.,Pawar, Rajendra P.,Tekale, Sunil U.
, (2021)
A highly efficient magnetically separable nano cobalt ferrite catalyst was synthesized via the sol-gel auto combustion method, characterized by powder XRD, SEM, TEM, UV–Visible, FT-IR, magnetic study, and BET isotherm analysis. The synthesized material was found to be an efficient heterogeneous Lewis acid catalyst for the synthesis of 2-aryl benzimidazole derivatives via solvent-free mechanochemical synthesis. The notable features of this new protocol include solvent-free reaction, cost-effectiveness, good yields, and environmental friendliness to afford the products within a short reaction time along with easy recovery and reuse of the nano catalyst.
Magnetically separable MnFe2O4 nano-material: An efficient and reusable heterogeneous catalyst for the synthesis of 2-substituted benzimidazoles and the extended synthesis of quinoxalines at room temperature under aerobic conditions
Brahmachari, Goutam,Laskar, Sujay,Barik, Puspendu
, p. 14245 - 14253 (2013)
A simple and efficient protocol has been developed for the synthesis of biologically relevant 2-substituted benzimidazoles and quinoxalines using magnetically separable manganese ferrite (MnFe2O4) nanopowder for the first time as a reusable heterogeneous catalyst at room temperature under aerobic conditions. MnFe2O4 nanoparticles were prepared by a simple sol-gel method using starch as a bio-polymeric matrix, and characterized by XRD, TEM, EDAX and VSM analyses. The Royal Society of Chemistry 2013.
Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent
Gioia, Maria Luisa Di,Cassano, Roberta,Costanzo, Paola,Cano, Natividad Herrera,Maiuolo, Loredana,Nardi, Monica,Nicoletta, Fiore Pasquale,Oliverio, Manuela,Procopio, Antonio
, (2019)
The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of green chemistry, represent an ever-present problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the development of compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such as antimicrobial, antiviral, anti-inflammatory, and analgesic activities, and some of the already synthesized compounds have found very strong applications in medicine praxis. Here we report a selective and sustainable method for the synthesis of 1,2-disubstituted or 2-substituted benzimidazoles, starting from o-phenylenediamine in the presence of different aldehydes. The use of deep eutectic solvent (DES), both as reaction medium and reagent without any external solvent, provides advantages in terms of yields as well as in the work up procedure of the reaction.
A nanoscopic icosahedral {Mo72Fe30} cluster catalyzes the aerobic synthesis of benzimidazoles
Garazhian, Zohreh,Rezaeifard, Abdolreza,Jafarpour, Maasoumeh
, p. 34854 - 34861 (2019)
In this study, the catalytic efficiency of amorphous {Mo72Fe30} nanocapsules as a safe Keplerate polyoxometalate in organic synthesis was exploited. The easy-made solid catalyst exhibited high efficiency using a very low dosage (0.02
