121-39-1Relevant articles and documents
-
Cristol,Norris
, (1954)
-
Efficient and selective peracetic acid epoxidation catalyzed by a robust manganese catalyst
Garcia-Bosch, Isaac,Company, Anna,Fontrodona, Xavier,Ribas, Xavi,Costas, Miquel
, p. 2095 - 2098 (2008)
(Chemical Equation Presented) A manganese catalyst containing a tetradentate ligand derived from triazacyclononane exhibits high catalytic activity in epoxidation reactions using peracetic acid as oxidant. The system exhibits broad substrate scope and requires small (0.1-0.15 mol %) catalyst loading. The catalyst is remarkably selective toward aliphatic cis-olefins. Mechanistic studies point toward an electrophilic oxidant delivering the oxygen atom in a concerted step.
Dioxiranes: Synthesis and Reactions of Methyldioxiranes
Murray, Robert W.,Jeyaraman, Ramasubbu
, p. 2847 - 2853 (1985)
The peroxymonosulfate-acetone system produces dimethyldioxirane under conditions permitting distillation of the dioxirane from the synthesis vessel.The same conditions were used to prepare other methyldioxiranes.Solutions of dimethyldioxirane prepared in this manner were used to study its chemical and spectroscopic properties.The caroate-acetone system was also used to study the chemistry of in situ generated dimethyldioxirane.
Metal-free ring-opening of epoxides with potassium trifluoroborates
Roscales, Silvia,Csaky, Aurelio G.
, p. 454 - 456 (2014)
The ring-opening of epoxides with potassium trifluoroborates proceeds smoothly in the presence of trifluoroacetic anhydride under metal-free conditions. The reactions are regioselective and afford a single diastereomer. Both electron-rich and electron-poor aryltrifluoroborates are tolerated.
SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME
-
Paragraph 0465; 0484; 0491, (2019/02/15)
The present disclosure relates to compounds of Formula (I): (I); and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as autoinflammatory and autoimmune diseases and cancers.
Bioinspired Manganese Complexes and Graphene Oxide Synergistically Catalyzed Asymmetric Epoxidation of Olefins with Aqueous Hydrogen Peroxide
Miao, Chengxia,Yan, Xingbin,Xu, Daqian,Xia, Chungu,Sun, Wei
, p. 476 - 484 (2017/02/10)
Bioinspired manganese complexes of N4ligands and graphene oxide (GO) synergistically catalyze the highly enantioselective epoxidation of olefins (up to 99% ee), which is a rare example with GO as a co-catalyst in asymmetric catalysis. GO as a new and key additive not only successfully functions in catalytic amounts, but also has a positive effect for improving the enantioselectivity of the asymmetric epoxidation compared with the traditional stoichiometric organic carboxylic acid method [e.g., chalcone, 95% ee (3.5 mg GO) vs. 84% ee (5 equiv., 75 mg acetic acid), ethyl cinnamate, 84% ee (3.5 mg GO) vs. 19% ee (5 equiv., 75 mg acetic acid)]. The X-ray photoelectron spectroscopy (XPS) spectra of GO before and after the reaction indicate that the intensities of C–O become stronger after the reaction, which may have a certain relationship with hydrogen peroxide (H2O2) and gives a reasonable rationale for the large consumption of H2O2. Also, part of the hydrogen peroxide was used for the oxidation of GO. (Figure presented.).
Enantioselective bio-hydrolysis of various racemic and meso aromatic epoxides using the recombinant epoxide hydrolase Kau2
Zhao, Wei,Kotik, Michael,Iacazio, Gilles,Archelas, Alain
, p. 1895 - 1908 (2015/06/02)
Abstract Epoxide hydrolase Kau2 overexpressed in Escherichia coli RE3 has been tested with ten different racemic and meso α,β-disubstituted aromatic epoxides. Some of the tested substrates were bi-functional, and most of them are very useful building blocks in synthetic chemistry applications. As a general trend Kau2 proved to be an extremely enantioselective biocatalyst, the diol products and remaining epoxides of the bioconversions being obtained - with two exceptions - in nearly enantiomerically pure form. Furthermore, the reaction times were usually very short (around 1 h, except when stilbene oxides were used), and the use of organic co-solvents was well tolerated, enabling very high substrate concentrations (up to 75 g/L) to be reached. Even extremely sterically demanding epoxides such as cis- and trans-stilbene oxides were transformed on a reasonable time scale. All reactions were successfully conducted on a 1 g preparative scale, generating diol- and epoxide-based chiral synthons with very high enantiomeric excesses and isolated yields close to the theoretical maximum. Thus we have here demonstrated the usefulness and versatility of lyophilized Escherichia coli cells expressing Kau2 epoxide hydrolase as a highly enantioselective biocatalyst for accessing very valuable optically pure aromatic epoxides and diols through kinetic resolution of racemates or desymmetrization of meso epoxides.