121601-93-2Relevant articles and documents
Synthesis and thermal, optical, and mechanical properties of sequence-controlled poly(1-adamantyl acrylate)-block-poly(n-butyl acrylate) containing polar side group
Nakano, Yoshinori,Sato, Eriko,Matsumoto, Akikazu
, p. 2899 - 2910 (2014)
We prepared the sequence-controlled block copolymers including poly(1-adamantyl acrylate) (PAdA) and poly(n-butyl acrylate) sequences as the hard and soft segments, respectively, by the organotellurium-mediated living radical polymerization. The thermal,
Synthesis of organic-inorganic polymer hybrids by means of host-guest interaction utilizing cyclodextrin
Ogoshi, Tomoki,Chujo, Yoshiki
, p. 654 - 660 (2003)
Organic -inorganic polymer hybrids were synthesized utilizing the host-guest interaction. Cyclodextrins (CDs, α-, β-, γ-CD) could be dispersed in the silica gel matrix at a nanometer level because of the hydrogen-bonding interaction between hydroxyl moieties of CD and residual silanol groups of silica gel. It is known that β-CD forms a strong host-guest complex with l-adamantanol in an aqueous solution. Thus, the organic polymer modified with an adamantane group at the side chain (ADA-PAA) and silica gel hybrids could be prepared by complexation of β-CD with ADA-PAA. β-CD played a role as a compatibilizer between ADA-PAA and silica gel to obtain transparent and homogeneous polymer hybrids. The evidence of the host-guest complex formation was confirmed by a fluorescence technique using a dansyl group. Furthermore, transparent and homogeneous CD-polymer complex/silica gel hybrids were prepared utilizing CDs formed polyrotaxane-type inclusion complexes with polymers, such as poly(ethylene glycol) and polyisobutylene.
Tautomycetin Synthetic Analogues: Selective Inhibitors of Protein Phosphatase I
Woydziak, Zachary R.,Yucel, A. John,Chamberlin, A. Richard
, p. 839 - 850 (2020/12/15)
Ser/Thr protein phosphatases (PPs) regulate a substantial range of cellular processes with protein phosphatases 1 (PP1) and 2 A (PP2A) accounting for over 90 % of the activity within cells. Nevertheless, tools to study PPs are limited as PPs inhibitors, particularly those selective for PP1 inhibition, are relatively scarce. Two examples of PP1-selective inhibitors, which share structural similarities, are tautomycin (TTM) and tautomycetin (TTN). This work describes the development of PP1/PP2A inhibitors that incorporate key structural features of TTM and TTN and are designed to conserve regions known to bind the active site of PP1/PP2A but vary regions that differentially contact the hydrophobic groove of PP1/PP2A. In all 28 TTN analogues were synthetically generated that inhibit PP1/PP2A activity at 50 values were determined for the seven most active analogues, which ranged from 34 to 1500 nM (PP1) and 70 to 6800 nM (PP2A). Four of the seven analogues possessed PP1 selectivity, and one demonstrated eightfold selectivity in the nanomolar range (PP1 IC50=34 nM, PP2A IC50=270 nM). A rationale is given for the observed differences in selectivity.
Acid- And base-switched palladium-catalyzed γ-C(sp3)-H alkylation and alkenylation of neopentylamine
Zhang, Jinquan,Zhang, Shuaizhong,Zou, Hongbin
supporting information, p. 3466 - 3471 (2021/05/31)
The functionalization of remote unactivated C(sp3)-H and the reaction selectivity are among the core pursuits for transition-metal catalytic system development. Herein, we report Pd-catalyzed γ-C(sp3)-H-selective alkylation and alkenylation with removable 7-azaindole as a directing group. Acid and base were found to be the decisive regulators for the selective alkylation and alkenylation, respectively, on the same single substrate under otherwise the same reaction conditions. Various acrylates were compatible for the formation of C(sp3)-C(sp3) and C(sp3)-C(sp2) bonds. The alkenylation protocol could be further extended to acrylates with natural product units and α,β-unsaturated ketones. The preliminary synthetic manipulation of the alkylation and alkenylation products demonstrates the potential of this strategy for structurally diverse aliphatic chain extension and functionalization. Mechanistic experimental studies showed that the acidic and basic catalytic transformations shared the same six-membered dimer palladacycle.
